Predictive Biomarkers and Personalized Medicine Opposing Effects of Runx 2 and Estradiol on Breast Cancer Cell Proliferation : In Vitro Identi fi cation of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

  2012influential reference
• Runx2 controls a feed‐forward loop between androgen and prolactin‐induced protein (PIP) in stimulating T47D cell proliferation

  2012cited by this paper
• Metastatic bone disease: role of transcription factors and future targets.

  2011cited by this paper
• Clinical Cancer esearch ing , Diagnosis , Prognosis omparison of PAM 50 Intrinsic Subtyping with unohistochemistry and Clinical Prognostic Factors in oxifen-Treated Estrogen Receptor – Positive R ast Cancer

  2010cited by this paper
• Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

  2010cited by this paper
• Runx2 in normal tissues and cancer cells: A developing story.

  2010influential reference
• Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation

  2010cited by this paper
• Runx2 in human breast carcinoma: its potential roles in cancer progression

  2010cited by this paper
• Molecular Profiling: Moving Away from Tumor Philately

  2010cited by this paper
• Gene expression profiles differentiating between breast cancers clinically responsive or resistant to letrozole.

  2009cited by this paper
• Regulation of bone development and extracellular matrix protein genes by RUNX2

  2009cited by this paper
• Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA.

  2009cited by this paper
• Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.

  2009cited by this paper
• Polo-like kinases: conservation and divergence in their functions and regulation

  2009cited by this paper
• Loss of RUNX3 Expression Correlates with Differentiation, Nodal Metastasis, and Poor Prognosis of Gastric Cancer

  2009cited by this paper
• Supervised risk predictor of breast cancer based on intrinsic subtypes.

  2009cited by this paper
• Runx2 Association with Progression of Prostate Cancer in Patients: Mechanisms Mediating Bone Osteolysis and Osteoblastic Metastatic Lesions

  2009cited by this paper
• Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.

  2009cited by this paper
• Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

  2009cited by this paper
• Role of estrogens and their receptors in adhesion and invasiveness of breast cancer cells.

  2008cited by this paper
• Ki-67 as Prognostic Marker in Early Breast Cancer: A Meta-analysis of Published Studies Involving 12 155 Patients

  2008cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer.

  2008influential reference
• The humoral immune system has a key prognostic impact in node-negative breast cancer.

  2008cited by this paper
• Human estrogen receptor alpha gene is a target of Runx2 transcription factor in osteoblasts.

  2007cited by this paper
• Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series

  2007cited by this paper
• Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole

  2007influential reference
• Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer.

  2007cited by this paper
• Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential

  2007cited by this paper
• Mutual transactivational repression of Runx2 and the androgen receptor by an impairment of their normal compartmentalization.

  2007cited by this paper
• Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?

  2007cited by this paper
• A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

  2006cited by this paper
• Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.

  2006cited by this paper
• The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts*

  2005cited by this paper
• The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion

  2005cited by this paper
• Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.

  2005influential reference
• Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation

  2005cited by this paper
• Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

  2005cited by this paper
• Frequent Loss of RUNX3 Expression by Promoter Hypermethylation in Gastric Carcinoma

  2004cited by this paper
• Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

  2004cited by this paper
• Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats

  2004cited by this paper
• Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

  2004cited by this paper
• Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

  2003cited by this paper
• Runx2 Integrates Estrogen Activity in Osteoblasts*

  2003cited by this paper
• Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.

  2003cited by this paper
• Phylogenesis and regulated expression of the RUNT domain transcription factors RUNX1 and RUNX3.

  2003cited by this paper
• Gene expression profiling predicts clinical outcome of breast cancer

  2002cited by this paper
• AML3/CBFα1 Is Required for Androgen-specific Activation of the Enhancer of the Mouse Sex-limited Protein (Slp) Gene*

  1999cited by this paper
• The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.

  1997cited by this paper
• Estrogen Receptor (cid:1) Controls a Gene Network in Luminal-Like Breast Cancer Cells Comprising Multiple Transcription Factors and MicroRNAs

  year unknowncited by this paper

• No citing papers are available for this paper.