Vitamin B6 nutritional status and cellular availability of pyridoxal 5'-phosphate govern the function of the transsulfuration pathway's canonical reactions and hydrogen sulfide production via side reactions.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biochimie

• Publication date

  2016-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.biochi.2015.12.020PMID 26765812PMCID PMC4899128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase.

  2008cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men.

  2005cited by this paper
• The role of cystathionine beta-synthase in homocysteine metabolism.

  2005influential reference
• Analysis of pathological defects in methionine metabolism using a simple mathematical model.

  2005cited by this paper
• The Role of Cystathionine β-Synthase in Homocysteine Metabolism

  2005cited by this paper
• Production of the Neuromodulator H2S by Cystathionine β-Synthase via the Condensation of Cysteine and Homocysteine*

  2004cited by this paper
• Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine.

  2004cited by this paper
• Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration.

  2000cited by this paper
• The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes.

  2000cited by this paper
• A substrate switch: a new mode of regulation in the methionine metabolic pathway.

  2000cited by this paper
• Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

  1999influential reference
• Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase.

  1999cited by this paper
• Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites.

  1999cited by this paper
• Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group.

  1998cited by this paper
• Low Circulating Folate and Vitamin B 6 Concentrations Risk Factors for Stroke, Peripheral Vascular Disease, and Coronary Artery Disease

  1998cited by this paper
• Methionine and cysteine kinetics at different intakes of methionine and cysteine in elderly men and women.

  1998cited by this paper
• Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.

  1998cited by this paper
• Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats

  1997cited by this paper
• Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.

  1996cited by this paper
• Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.

  1995cited by this paper
• Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats.

  1994cited by this paper
• Antioxidant Functions of Vitamins

  1992cited by this paper
• Purification and properties of cystathionine beta-synthase from human liver. Evidence for identical subunits.

  1978cited by this paper
• Metabolism of methionine in oral contraceptive users and control women receiving controlled intakes of vitamin B6.

  1977cited by this paper
• Production of apoenzymes of serine sulfhydrase and cystathionine-beta-synthase and their interaction with pyridoxal-5'-phosphate and its analogs.

  1974cited by this paper
• Production of apoenzymes of serine sulfhydrase and cystathionine-beta-synthase and their interaction with pyridoxal-5'-phosphate and its analogs.

  1974cited by this paper
• Binding of pyridoxal 5-phosphate to cystathionase.

  1973cited by this paper
• Effect of vitamin B6 depletion in adult man on the plasma concentration and the urinary excretion of free amino acids.

  1971influential reference
• Studies on cystathionine synthetase characteristics of purified rat liver enzyme.

  1971cited by this paper
• Effect of vitamin B6 depletion in adult man on the excretion of cystathionine and other methionine metabolites.

  1970influential reference
• Pyridoxine effects on cystathionine synthase in rat liver.

  1970cited by this paper

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  2022cites this paper
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  2022cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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