Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Philosophical Transactions of the Royal Society B: Biological Sciences

• Publication date

  2015-10-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1098/rstb.2015.0029PMID 26370941PMCID PMC4632605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane

  2015cited by this paper
• Distinct conformational spectrum of homologous multidrug ABC transporters.

  2015cited by this paper
• LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

  2014cited by this paper
• Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport

  2014cited by this paper
• Structural basis for lipopolysaccharide insertion in the bacterial outer membrane

  2014cited by this paper
• Biosynthesis and export of bacterial lipopolysaccharides.

  2014cited by this paper
• Structural basis for outer membrane lipopolysaccharide insertion

  2014cited by this paper
• The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

  2013cited by this paper
• Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress

  2013cited by this paper
• Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA*

  2013cited by this paper
• On the essentiality of lipopolysaccharide to Gram-negative bacteria.

  2013cited by this paper
• Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance in Burkholderia cenocepacia †

  2012cited by this paper
• Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export.

  2012cited by this paper
• Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

  2012cited by this paper
• The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel

  2011cited by this paper
• Signal integration by DegS and RseB governs the σE-mediated envelope stress response in Escherichia coli

  2011cited by this paper
• Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane

  2010cited by this paper
• Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

  2010cited by this paper
• The bacterial cell envelope.

  2010cited by this paper
• Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex.

  2010cited by this paper
• Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export Pathway in Escherichia coli

  2010influential reference
• The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites

  2009cited by this paper
• Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides

  2009cited by this paper
• Novel structure of the conserved gram-negative lipopolysaccharide transport protein A and mutagenesis analysis.

  2008cited by this paper
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

  2008cited by this paper
• Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

  2008cited by this paper
• Functional Analysis of the Protein Machinery Required for Transport of Lipopolysaccharide to the Outer Membrane of Escherichia coli

  2008influential reference
• Membrane lipids: where they are and how they behave

  2008cited by this paper
• Flexibility in the ABC transporter MsbA: Alternating access with a twist

  2007cited by this paper
• Diversity of endotoxin and its impact on pathogenesis.

  2006influential reference
• Invited review: Diversity of endotoxin and its impact on pathogenesis

  2006cited by this paper
• Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli.

  2006cited by this paper
• Characterization of lptA and lptB, Two Essential Genes Implicated in Lipopolysaccharide Transport to the Outer Membrane of Escherichia coli

  2006cited by this paper
• Non-essential KDO biosynthesis and new essential cell envelope biogenesis genes in the Escherichia coli yrbG-yhbG locus.

  2006cited by this paper
• Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate

  2005cited by this paper
• Viability of a Capsule- and Lipopolysaccharide-Deficient Mutant of Neisseria meningitidis

  2005cited by this paper
• Lipopolysaccharide Transport to the Bacterial Outer Membrane in Spheroplasts*

  2005cited by this paper
• MsbA-dependent Translocation of Lipids across the Inner Membrane of Escherichia coli*

  2004cited by this paper
• Biogenesis of the gram-negative bacterial outer membrane.

  2004cited by this paper
• Scanning the Escherichia coli chromosome by random transposon mutagenesis and multiple phenotypic screening.

  2004cited by this paper
• The ATP Binding Cassette Multidrug Transporter LmrA and Lipid Transporter MsbA Have Overlapping Substrate Specificities*

  2003cited by this paper
• Molecular Basis of Bacterial Outer Membrane Permeability Revisited

  2003cited by this paper
• Lipopolysaccharide endotoxins.

  2002cited by this paper
• Imp/OstA is required for cell envelope biogenesis in Escherichia coli

  2002cited by this paper
• Outer membrane composition of a lipopolysaccharide‐deficient Neisseria meningitidis mutant

  2001cited by this paper
• Genetics of O-Antigen Biosynthesis inPseudomonas aeruginosa

  1999cited by this paper
• Meningitis bacterium is viable without endotoxin

  1998cited by this paper
• Function of Escherichia coli MsbA, an Essential ABC Family Transporter, in Lipid A and Phospholipid Biosynthesis*

  1998cited by this paper
• Meningitis bacterium is viable without endotoxin.

  1998cited by this paper
• Microbiology and molecular biology reviews : MMBR.

  1997influential reference
• Function of the Escherichia coli msbB Gene, a Multicopy Suppressor of htrB Knockouts, in the Acylation of Lipid A

  1997cited by this paper
• Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter

  1996cited by this paper
• Function of the htrB High Temperature Requirement Gene of Escherichia coli in the Acylation of Lipid A

  1996cited by this paper
• The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP‐dependent translocators

  1993cited by this paper
• Zones of membrane adhesion in the cryofixed envelope of Escherichia coli.

  1991cited by this paper
• The ‘Bayer bridges’ confronted with results from improved electron microscopy methods

  1990cited by this paper
• Outer membrane of Salmonella typhimurium: accessibility of phospholipid head groups to phospholipase c and cyanogen bromide activated dextran in the external medium.

  1976cited by this paper
• Asymmetrical distribution and artifactual reorientation of lipopolysaccharide in the outer membrane bilayer of Salmonella typhimurium.

  1975cited by this paper
• Outer membrane of salmonella. Sites of export of newly synthesised lipopolysaccharide on the bacterial surface.

  1973cited by this paper
• Mechanism of assembly of the outer membrane of Salmonella typhimurium. Site of synthesis of lipopolysaccharide.

  1972influential reference
• Mechanism of assembly of the outer membrane of Salmonella typhimurium. Isolation and characterization of cytoplasmic and outer membrane.

  1972cited by this paper
• The topography of the bacterial cell wall.

  1969cited by this paper
• Areas of adhesion between wall and membrane of Escherichia coli.

  1968cited by this paper
• Separation by density gradient centrifugation of two types of membranes from spheroplast membrane of Escherichia coli K12.

  1968cited by this paper
• Release of lipopolysaccharide by EDTA treatment of E. coli.

  1965cited by this paper
• ULTRASTRUCTURE OF VEILLONELLA AND MORPHOLOGICAL CORRELATION OF AN OUTER MEMBRANE WITH PARTICLES ASSOCIATED WITH ENDOTOXIC ACTIVITY

  1964cited by this paper
• Cell Wall and Cytoplasmic Membrane of Escherichia coli

  1958cited by this paper
• LSU Digital Commons LSU Digital Commons ATPase activity of the MsbA lipid flippase of Escherichia coli ATPase activity of the MsbA lipid flippase of Escherichia coli

  year unknowncited by this paper

• Recent insights into Wzy polymerases and lipopolysaccharide O-antigen biosynthesis

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• VIRULENCE FACTORS OF E. COLI, ASSOCIATED WITH URINARY TRACT INFECTIONS

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• PCSK9 in critical illness - it's not all about lipids.

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• Machine Learning Models and Structure‐Based Antibacterial Drug Discovery of the Key ABC Transporter Maltose‐Binding Protein A

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• Structural analysis of LabB from Klebsiella pneumoniae reveals an alternative dimeric conformation generated by the sliding of TPR motifs.

  2025cites this paper
• Inhibiting Lipopolysaccharide Biogenesis: The More You Know the Further You Go.

  2025cites this paper
• Lipid interactions are important for the Tol-Pal complex in maintaining outer membrane lipid homeostasis

  2025cites this paper
• A case of polycystic kidney disease infection caused by Brucella: report and literature review

  2025cites this paper
• The Tol Pal system integrates maintenance of the three layered cell envelope

  2024cites this paper
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• In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD

  2024cites this paper
• Lipopolysaccharide as an antibiotic target.

  2023cites this paper
• Inhibitory mechanisms of promising antimicrobials from plant byproducts: A review.

  2023cites this paper
• Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium

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• Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options

  2023cites this paper
• Use of Mutagenesis and Functional Screens to Characterize Essential Genes Involved in Lipopolysaccharide Transport.

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  2022cites this paper
• Cracking outer membrane biogenesis.

  2022cites this paper
• Cryo-EM Analysis of the Lipopolysaccharide Flippase MsbA.

  2022cites this paper
• Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice

  2021cites this paper
• YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth

  2021cites this paper
• Evidence for the Mycobacterial Mce4 Transporter Being a Multiprotein Complex

  2021cites this paper
• Transport of lipopolysaccharides and phospholipids to the outer membrane.

  2021cites this paper
• Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

  2021cites this paper
• Structural systems pharmacology: A framework for integrating metabolic network and structure-based virtual screening for drug discovery against bacteria

  2021cites this paper
• Conserved Tandem Arginines for PbgA/YejM Allow Salmonella Typhimurium To Regulate LpxC and Control Lipopolysaccharide Biogenesis during Infection

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• What is the Cause of Recurrent Urinary Tract Infection? Contemporary Microscopic Concepts of Pathophysiology

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• A Rapid Fluorescence-Based Microplate Assay to Investigate the Interaction of Membrane Active Antimicrobial Peptides with Whole Gram-Positive Bacteria

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• Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems

  2020cites this paper
• Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms

  2020cites this paper
• Virulence Genetics of an Erwinia amylovora Putative Polysaccharide Transporter Family Member

  2020cites this paper
• Border Control: Regulating LPS Biogenesis.

  2020cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper