Epigenetic inactivation of RASSF1a in uveal melanoma.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/IOVS.06-0781PMID 17251440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

  2006cited by this paper
• Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas

  2006cited by this paper
• Microarray analysis of promoter methylation in lung cancers

  2006cited by this paper
• Uveal and cutaneous melanoma: shared expression characteristics of melanoma-associated antigens.

  2005cited by this paper
• DNA methylation and human disease

  2005cited by this paper
• Methylation of the Tumor Suppressor Gene RASSF1A in Human Tumors

  2005cited by this paper
• High frequency of promoter hypermethylation of RASSF1A in tumorous and non‐tumourous tissue of breast cancer

  2005cited by this paper
• [DNA methylation and cancer].

  2005cited by this paper
• Concurrent loss of chromosome arm 1p and chromosome 3 predicts a decreased disease-free survival in uveal melanoma patients.

  2005cited by this paper
• Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma.

  2005cited by this paper
• Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia

  2004cited by this paper
• DNA methylation and cancer.

  2004cited by this paper
• Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development

  2003cited by this paper
• Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development

  2003cited by this paper
• Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma.

  2003cited by this paper
• The fundamental role of epigenetic events in cancer

  2002cited by this paper
• Detection of genetic prognostic markers in uveal melanoma biopsies using fluorescence in situ hybridization.

  2002cited by this paper
• The RASSF1A Tumor Suppressor Blocks Cell Cycle Progression and Inhibits Cyclin D1 Accumulation

  2002influential reference
• Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

  2001cited by this paper
• Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.

  2001cited by this paper
• Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

  2000cited by this paper
• Acquired homozygosity (isodisomy) of chromosome 3 in uveal melanoma.

  1998cited by this paper
• HLA expression in a primary uveal melanoma, its cell line, and four of its metastases

  1997cited by this paper
• Prognostic implications of monosomy 3 in uveal melanoma.

  1996cited by this paper
• Establishment and characterization of an uveal‐melanoma cell line

  1995influential reference
• Cytogenetic findings in six posterior uveal melanomas: Involvement of chromosomes 3, 6, and 8

  1990cited by this paper
• Nonrandom chromosomal abnormalities in primary uveal melanoma.

  1990cited by this paper
• Cytogenetic findings on six posterior uveal melanomas

  1990cited by this paper
• Monosomy 3 and isochromosome 8q in a uveal melanoma.

  1990cited by this paper
• Epidemiologic aspects of uveal melanoma.

  1988cited by this paper

• Recent advances in the molecular genetic mechanisms and immune microenvironment of uveal melanoma.

  2026cites this paper
• Genome-Wide Methylation Patterns in Primary Uveal Melanoma: Development of MethylSig-UM, an Epigenomic Prognostic Signature to Improve Patient Stratification

  2024cites this paper
• Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

  2022cites this paper
• Genetic Basis and Molecular Mechanisms of Uveal Melanoma Metastasis: A Focus on Prognosis

  2022cites this paper
• Integrative analysis of DNA methylation and gene expression in skin cutaneous melanoma by bioinformatic approaches

  2021cites this paper
• Potential of miRNA-Based Nanotherapeutics for Uveal Melanoma

  2021cites this paper
• Epigenetics in ocular medicine

  2021cites this paper
• Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy

  2021cites this paper
• Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma.

  2021cites this paper
• Current molecular and clinical insights into uveal melanoma (Review)

  2021cites this paper
• Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location‐dependent patterns of genetic and epigenetic alterations

  2021cites this paper
• Signal pathways of melanoma and targeted therapy

  2021cites this paper
• RNA m6A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c‐Met

  2020cites this paper
• Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.

  2020cites this paper
• Machine learning-based integrative analysis of methylome and transcriptome identifies novel prognostic DNA methylation signature in uveal melanoma

  2020cites this paper
• Update on uveal melanoma: Translational research from biology to clinical practice (Review)

  2020cites this paper
• Quantification of DNA methylation independent of sodium bisulfite conversion using methylation‐sensitive restriction enzymes and digital PCR

  2020cites this paper
• Unpacking the genetic etiology of uveal melanoma

  2020cites this paper
• Targeting Epigenetic Modifications in Uveal Melanoma

  2020cites this paper
• Genetics of Uveal Melanoma

  2019cites this paper
• Quantification of DNA methylation using methylation-sensitive restriction enzymes and multiplex digital PCR

  2019cites this paper
• Long-term survival of uveal melanoma patients after enucleation, depending on molecular genetic aberrations

  2018cites this paper
• Genetic and epigenetic insights into uveal melanoma

  2018cites this paper
• DNA Methylation and Uveal Melanoma

  2018cites this paper
• DNA methylation profiles in cancer diagnosis and therapeutics

  2018cites this paper
• Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities

  2017cites this paper
• Uveal melanoma: epidemiology, etiology, and treatment of primary disease

  2017cites this paper
• Role of Epigenetics in Uveal Melanoma

  2017influential citation
• Mutation analysis and gene expression profiling of ocular melanomas in cats

  2017cites this paper
• Epigenetics and Common Ophthalmic Diseases

  2016cites this paper
• Orchestrating epigenetic roles targeting ocular tumors

  2016cites this paper
• [. Role of molecular and genetic factors in survival from uveal melanoma].

  2016cites this paper
• Epigenetics in Ocular Medicine

  2016cites this paper
• Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.

  2015cites this paper
• What constitutes a healthy eye? Investigations of genetic and environmental influences in eye disease

  2015cites this paper
• Genetic determinants of uveal melanoma

  2014cites this paper
• Epigenetics and Ocular Diseases: From Basic Biology to Clinical Study

  2014cites this paper
• Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis

  2014cites this paper
• Hypomethylation of the IL 17 RC Promoter in Peripheral Blood Leukocytes Is Not A Hallmark of Age-Related Macular Degeneration

  2014cites this paper
• Ocular melanoma and the BAP1 hereditary cancer syndrome: implications for the dermatologist

  2014cites this paper
• Prognostic Testing in Uveal Melanoma

  2013cites this paper
• Mrassf1a-Pap, a Novel Methylation-Based Assay for the Detection of Cell-Free Fetal DNA in Maternal Plasma

  2013cites this paper
• Rapid and inexpensive body fluid identification by RNA profiling-based multiplex High Resolution Melt (HRM) analysis.

  2013cites this paper
• Epigenetic regulation of CXCR4 expression by the ocular microenvironment.

  2013cites this paper
• Anatomy and Pathology Epigenetic Regulation of CXCR 4 Expression by the Ocular Microenvironment

  2013cites this paper
• Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration.

  2013cites this paper
• Review: Epigenetic mechanisms in ocular disease

  2013cites this paper
• Rapid and inexpensive body fluid identification by RNA profiling-based multiplex High Resolution Melt (HRM) analysis

  2013cites this paper
• [Duplex genotyping of CYP2C19*2 and CYP2C19*3 by high-resolution melting curve analysis].

  2013cites this paper
• Chapter 33 – Epigenetic Mechanisms of Retinal Disease

  2012cites this paper
• The role of RASSF1A in uveal melanoma.

  2012cites this paper
• Genetic prognostic factors in uveal melanoma

  2012cites this paper
• Archival Toxicoepigenetics: Molecular Analysis of Modified DNA from Preserved Tissues in Toxicology Studies

  2012cites this paper
• Epigenetic regulation of miRNA genes and their role in human melanomas.

  2012cites this paper
• Anatomy and Pathology The Role of RASSF 1 A in Uveal Melanoma

  2012influential citation
• 7 Genetics of Uveal Melanoma

  2012cites this paper
• A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.

  2012cites this paper
• Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer.

  2011cites this paper
• Status of RASSF1A in Uveal Melanocytes and Melanoma Cells

  2011cites this paper
• Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease

  2011cites this paper
• EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

  2011cites this paper
• From Melanocyte to Malignant Metastatic Melanoma

  2010cites this paper
• Tumor Heterogeneity in Uveal Melanomas

  2010cites this paper
• Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind?

  2010cites this paper
• Methylation analysis of BRCA1, RASSF1, GSTP1 and EPHB2 promoters in prostate biopsies according to different degrees of malignancy.

  2009cites this paper
• Insights of Tumorigenesis

  2009cites this paper
• Pedro Miguel Teixeira Pinto “ Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer

  2009cites this paper
• Epigenetic targets in cancer epidemiology.

  2009cites this paper
• Genetics of uveal melanoma

  2009cites this paper
• High‐Resolution Melting Analysis (HRMA)—More than just sequence variant screening

  2009cites this paper
• Gene expression profiling in uveal melanoma: two regions on 3p related to prognosis.

  2008influential citation
• Methylation of CpG island promoters in uveal melanoma

  2008cites this paper
• Frequent RASSF1A Gene Promoter Hypermethylation in Breast Cancer

  2008cites this paper
• Frequent RASSF 1 A Gene Promoter Hypermethylation in Breast Cancer

  2008influential citation
• Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma.

  2008cites this paper
• Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma.

  2008cites this paper
• Methylation in uveal melanoma

  2008cites this paper
• Analyses of aqueous humour ghrelin levels of eyes with and without glaucoma

  2008cites this paper
• The T1799A point mutation is present in posterior uveal melanoma

  2008cites this paper
• Molecular Prognostic Markers in Uveal Melanoma: Expression Profiling and Genomic Studies

  2008cites this paper
• Promoter methylation status of multiple genes in uveal melanoma.

  2007influential citation