In vivo effects of PCB-126 and genistein on vitellogenin expression in zebrafish

Abstract In this study, the vitellogenin (Vtg) modulation by genistein and polychlorinated biphenyl-126 (PCB-126) exposure in zebrafishes has been investigated. Both PCB-126 and genistein have been identified as aquatic pollutants and can further increase estrogenicity of waterways. Vtg is egg yolk precursor protein release by the hepatocytes during vitellogenesis. This process occurs normally in the hepatocytes in response to the activation with the estrogens such as 17-β-estradiol. Our immunohistochemical findings showed a Vtg expression that increases at 12 h and at 72 h in the liver of treated fishes with both PCB-126 and genistein, individually and in combination. Furthermore, for the first time, also hepatic stellate cells (HSC) in the liver parenchyma were strongly positive for vitellogenin.

• Publication year

  2019

• Venue

  Natural Product Research

• Publication date

  2019-09-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1080/14786419.2018.1455048PMID 29607746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
• Estrogen receptor-hijacking by dioxin-like 3,3'4,4',5-pentachlorobiphenyl (PCB126) in salmon hepatocytes involves both receptor activation and receptor protein stability.

  2012cited by this paper
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  2012cited by this paper
• Perfluorooctane sulfonamide-mediated modulation of hepatocellular lipid homeostasis and oxidative stress responses in Atlantic salmon hepatocytes.

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• Estrogen and Xenoestrogens in Breast Cancer

  2010cited by this paper
• Estrogenic followed by anti-estrogenic effects of PCBs exposure in juvenil fish (Spaurus aurata).

  2010cited by this paper
• Developmental toxicity and brain aromatase induction by high genistein concentrations in zebrafish embryos

  2009cited by this paper
• Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption.

  2009influential reference
• Citrus bergamia risso & poiteau juice protects against renal injury of diet‐induced hypercholesterolemia in rats

  2009cited by this paper
• Effects of 17α-ethynylestradiol on hormonal responses and xenobiotic biotransformation system of Atlantic salmon (Salmo salar)

  2007cited by this paper
• Effects of 17alpha-ethynylestradiol on hormonal responses and xenobiotic biotransformation system of Atlantic salmon (Salmo salar).

  2007cited by this paper
• Endocrine Disrupters in the Aquatic Environment: An Overview

  2005cited by this paper
• Vitellogenin: A Review of Analytical Methods to Detect (Anti) Estrogenic Activity in Fish

  2005influential reference
• Phytoestrogens.

  2004cited by this paper
• Small fish models for identifying and assessing the effects of endocrine-disrupting chemicals.

  2004cited by this paper
• Organochlorine pesticides, PCBs and heavy metals in tissues of the mullet Liza aurata in lake Ganzirri and Straits of Messina (Sicily, Italy).

  2003cited by this paper
• Endocrine disruptors: from Wingspread to environmental developmental biology.

  2002cited by this paper
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  2002cited by this paper
• The effect of phytoestrogens on the female genital tract.

  2002cited by this paper
• Phyto-oestrogens and cancer.

  2002cited by this paper
• Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity.

  2001cited by this paper
• Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation

  2000cited by this paper
• Vitellogenesis as a biomarker of reproductive disruption by xenobiotics

  1999influential reference
• An updated review of environmental estrogen and androgen mimics and antagonists.

  1998cited by this paper
• Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.

  1998cited by this paper
• Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.

  1998cited by this paper
• Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment.

  1995cited by this paper
• A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic.

  1995cited by this paper
• Toxic equivalency factors for dioxin-like PCBs

  1994cited by this paper
• Aerial and aquatic oxygen uptake in the amphibious Red Sea rockskipper fish, Alticus kirki (family Blenniidae)

  1992cited by this paper
• Phytoestrogens

  1970cited by this paper

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  2019cites this paper
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  2019cites this paper
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