Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Pharmacology, Biochemistry and Behavior

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.PBB.2003.08.020PMID 14724035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.

  2003cited by this paper
• Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of L-arginine on picrotoxin-induced convulsions in rats.

  2002cited by this paper
• Effects of the nitric oxide donor molsidomine on different memory components as assessed in the object-recognition task in the rat

  2002cited by this paper
• Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain

  2001cited by this paper
• Pharmacokinetics and Pharmacodynamics of 7-Nitroindazole, a Selective Nitric Oxide Synthase Inhibitor, in the Rat Hippocampus

  2001cited by this paper
• Accelerated forgetting in patients with epilepsy: evidence for an impairment in memory consolidation.

  2000cited by this paper
• 7-Nitroindazole potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice.

  2000cited by this paper
• Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid.

  1999cited by this paper
• Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension.

  1999cited by this paper
• Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid.

  1999cited by this paper
• Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats.

  1998cited by this paper
• The influence of L-NG-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice

  1998cited by this paper
• Nitric oxide synthase inhibitors L-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced excitotoxicity.

  1998cited by this paper
• Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures.

  1998cited by this paper
• Impaired learning in rats in a 14-unit T-maze by 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, is attenuated by the nitric oxide donor, molsidomine.

  1998cited by this paper
• Influence of 7-nitroindazole on the anticonvulsive action of conventional antiepileptic drugs.

  1997cited by this paper
• L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice.

  1997cited by this paper
• Anticonvulsant effects of 7‐nitroindazole in rodents with reflex epilepsy may result from L‐arginine accumulation or a reduction in nitric oxide or L‐citrulline formation

  1996cited by this paper
• Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine.

  1996cited by this paper
• NG-nitro-L-arginine differentially affects glutamate- or kainate-induced seizures.

  1996cited by this paper
• Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.

  1996cited by this paper
• 7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilatation in response to N-methyl-D-aspartate.

  1995cited by this paper
• Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.

  1995cited by this paper
• Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.

  1995cited by this paper
• 7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures.

  1995cited by this paper
• Nitric oxide synthesis, epileptic seizures and kindling

  1995cited by this paper
• The role of nitric oxide in the kainate-induced seizures in mice.

  1994cited by this paper
• Nitric-oxide synthase assays.

  1994cited by this paper
• A technique for quantitative measurement of clonic convulsions in rats.

  1994cited by this paper
• Evidence that sodium nitroprusside possesses anticonvulsant effects mediated through nitric oxide.

  1994cited by this paper
• Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats.

  1994cited by this paper
• Gases as biological messengers: nitric oxide and carbon monoxide in the brain

  1994cited by this paper
• Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole.

  1994cited by this paper
• α‐Guanidinoglutaric Acid, an Endogenous Convulsant, as a Novel Nitric Oxide Synthase Inhibitor

  1994cited by this paper
• Nitric oxide: an endogenous anticonvulsant substance

  1993cited by this paper
• Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME.

  1993cited by this paper
• L-nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats.

  1993cited by this paper
• Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

  1993cited by this paper
• Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.

  1992cited by this paper
• Isolation and Identification of Methylarginines from Bovine Brain

  1992cited by this paper
• The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. IV. Protective indices.

  1991cited by this paper
• A requirement for the intercellular messenger nitric oxide in long-term potentiation.

  1991cited by this paper
• Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

  1990cited by this paper
• Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

  1990cited by this paper
• The sex-related difference in the convulsant action of picrotoxin in rats.

  1988cited by this paper
• Record in Grade School of Pupils with Epilepsy: An Epidemiological Study

  1976cited by this paper
• Evaluation of drug activities : pharmacometrics

  1964cited by this paper

• Antioxidant effect of esculin and sulforaphane in zebrafish larvae: A comparative study.

  2025cites this paper
• In silico and in vivo assessment of developmental toxicity, oxidative stress response & Na+/K+-ATPase activity in zebrafish embryos exposed to cypermethrin.

  2023cites this paper
• Evaluation of Developmental Toxicity and Oxidative Stress Caused by Zinc Oxide Nanoparticles in Zebra Fish Embryos/ Larvae

  2023cites this paper
• Evaluation of Maghemite Nanoparticles–Induced Developmental Toxicity and Oxidative Stress in Zebrafish Embryos/Larvae

  2021cites this paper
• Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a d-galactose-induced mouse model

  2014cites this paper
• Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.

  2013cites this paper
• Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice.

  2013cites this paper
• Do inhalational anesthetics cause cognitive dysfunction?

  2011cites this paper
• The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats.

  2011cites this paper
• Involvement of nitric oxide in learning & memory processes

  2011cites this paper
• The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex.

  2011cites this paper
• Ruhsal bozukluklarõn psikobiyolojisinde nitrik oksit

  2009cites this paper
• Modulation of the Epileptic Seizure Threshold: Implications of Biphasic Dose Responses

  2008cites this paper
• Different effects of nitric oxide synthase inhibitors on convulsions induced by nicotine in mice.

  2007influential citation
• Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats

  2007cites this paper
• Nitric oxide is involved in the memory facilitation induced by spermidine in rats

  2006cites this paper
• 7-Nitroindazole enhances dose-dependently the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

  2006influential citation
• 7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model

  2006cites this paper
• Persistent exercise attenuates nicotine- but not clonidine-induced antinociception in female rats.

  2006cites this paper
• Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.

  2005cites this paper