Quantitative Map of β-Lactone-Induced Virulence Regulation.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Proteome Research

• Publication date

  2017-02-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.jproteome.6b00705PMID 28186774
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression.

  2016cited by this paper
• Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.

  2015cited by this paper
• RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA

  2015cited by this paper
• AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

  2015cited by this paper
• Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization.

  2015cited by this paper
• Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

  2014cited by this paper
• Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition.

  2014cited by this paper
• A β‐Lactone‐Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice

  2014cited by this paper
• Influence of the AgrC-AgrA Complex on the Response Time of Staphylococcus aureus Quorum Sensing

  2014cited by this paper
• A Non-Coding RNA Promotes Bacterial Persistence and Decreases Virulence by Regulating a Regulator in Staphylococcus aureus

  2014cited by this paper
• Role of Adaptor TrfA and ClpPC in Controlling Levels of SsrA-Tagged Proteins and Antitoxins in Staphylococcus aureus

  2014cited by this paper
• The mechanism of caseinolytic protease (ClpP) inhibition.

  2013cited by this paper
• Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.

  2013cited by this paper
• The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

  2012cited by this paper
• Life and Death of Proteins: A Case Study of Glucose-starved Staphylococcus aureus*

  2012cited by this paper
• Baicalin protects mice from Staphylococcus aureus pneumonia via inhibition of the cytolytic activity of α-hemolysin.

  2012cited by this paper
• New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564.

  2012cited by this paper
• Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein*

  2012cited by this paper
• AAA+ proteases: ATP-fueled machines of protein destruction.

  2011cited by this paper
• Coordinated Regulation by AgrA, SarA, and SarR To Control agr Expression in Staphylococcus aureus

  2011cited by this paper
• Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus.

  2010cited by this paper
• The Chaperone ClpX Stimulates Expression of Staphylococcus aureus Protein A by Rot Dependent and Independent Pathways

  2010cited by this paper
• Molecular Determinants of MecA as a Degradation Tag for the ClpCP Protease*

  2009cited by this paper
• Staphylococcus aureus infections.

  2009cited by this paper
• Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.

  2009cited by this paper
• A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation

  2009cited by this paper
• The SarA protein family of Staphylococcus aureus.

  2008cited by this paper
• A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

  2008cited by this paper
• SarZ Promotes the Expression of Virulence Factors and Represses Biofilm Formation by Modulating SarA and agr in Staphylococcus aureus

  2008cited by this paper
• Activity-based probes as a tool for functional proteomic analysis of proteases

  2008cited by this paper
• Beta-lactones as privileged structures for the active-site labeling of versatile bacterial enzyme classes.

  2008cited by this paper
• Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus.

  2008cited by this paper
• Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism.

  2007cited by this paper
• Molecular Mechanisms of agr Quorum Sensing in Virulent Staphylococci

  2007cited by this paper
• Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

  2007cited by this paper
• Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram‐positive bacteria

  2007cited by this paper
• Global Regulatory Impact of ClpP Protease of Staphylococcus aureus on Regulons Involved in Virulence, Oxidative Stress Response, Autolysis, and DNA Repair

  2006cited by this paper
• Inhibition of rot translation by RNAIII, a key feature of agr function

  2006cited by this paper
• Mechanism-based profiling of enzyme families.

  2006cited by this paper
• Rat/MgrA, a Regulator of Autolysis, Is a Regulator of Virulence Genes in Staphylococcus aureus

  2005cited by this paper
• Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

  2005cited by this paper
• BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks

  2005cited by this paper
• Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression

  2005cited by this paper
• Global Virulence Regulation in Staphylococcus aureus: Pinpointing the Roles of ClpP and ClpX in the sar/agr Regulatory Network

  2005cited by this paper
• Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

  2005cited by this paper
• Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

  2004cited by this paper
• Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus.

  2004cited by this paper
• β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is Essential for Bacterial Fatty Acid Synthesis*

  2003cited by this paper
• Loss of hemolysin expression in Staphylococcus aureus agr mutants correlates with selective survival during mixed infections in murine abscesses and wounds.

  2003cited by this paper
• Autoinduction and signal transduction in the regulation of staphylococcal virulence

  2003cited by this paper
• sarU, a sarA Homolog, Is Repressed by SarT and Regulates Virulence Genes in Staphylococcus aureus

  2003cited by this paper
• Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

  2003cited by this paper
• Stable-isotope dimethyl labeling for quantitative proteomics.

  2003cited by this paper
• Beta-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis.

  2003cited by this paper
• Cytoscape: a software environment for integrated models of biomolecular interaction networks.

  2003cited by this paper
• σB Modulates Virulence Determinant Expression and Stress Resistance: Characterization of a Functional rsbU Strain Derived from Staphylococcus aureus 8325-4

  2002cited by this paper
• Disruption of the Genes for ClpXP Protease in Salmonella enterica Serovar Typhimurium Results in Persistent Infection in Mice, and Development of Persistence Requires Endogenous Gamma Interferon and Tumor Necrosis Factor Alpha

  2001cited by this paper
• Transcription Profiling-Based Identification ofStaphylococcus aureus Genes Regulated by the agrand/or sarA Loci

  2001cited by this paper
• ςB Activity in Staphylococcus aureus Is Controlled by RsbU and an Additional Factor(s) during Bacterial Growth

  2001cited by this paper
• Beta-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2).

  2001cited by this paper
• Characterization of sarR, a Modulator ofsar Expression in Staphylococcus aureus

  2001cited by this paper
• Response of Bacillus subtilis to Cerulenin and Acquisition of Resistance

  2001cited by this paper
• β-Ketoacyl Acyl Carrier Protein Synthase III (FabH) Is Essential for Fatty Acid Biosynthesis in Streptomyces coelicolor A3(2)

  2001cited by this paper
• ςB Activity Depends on RsbU inStaphylococcus aureus

  2001cited by this paper
• Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression.

  2000cited by this paper
• The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes

  2000cited by this paper
• Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus

  2000cited by this paper
• ClpP participates in the degradation of misfolded protein in Lactococcus lactis

  1999cited by this paper
• Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimurium

  1999cited by this paper
• Deletion of the Alternative Sigma Factor ςB in Staphylococcus aureus Reveals Its Function as a Global Regulator of Virulence Genes

  1998cited by this paper
• Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor

  1998cited by this paper
• Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis.

  1997cited by this paper
• Activation of alpha‐toxin translation in Staphylococcus aureus by the trans‐encoded antisense RNA, RNAIII.

  1995cited by this paper
• Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.

  1993cited by this paper
• Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12

  1992cited by this paper
• Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus

  1989cited by this paper

• A Photocrosslinking Probe to Capture the Substrates of Caseinolytic Protease P.

  2024cites this paper
• β-Lactams from the Ocean

  2023cites this paper
• Targeting caseinolytic protease P and its AAA1 chaperone for tuberculosis treatment.

  2023cites this paper
• Molecular analysis of Brevibacillus brevis as polyethylene biodegradation agents

  2023cites this paper
• Armeniaspirol analogues with more potent Gram-positive antibiotic activity show enhanced inhibition of the ATP-dependent proteases ClpXP and ClpYQ.

  2022cites this paper
• Tailored Phenyl Esters Inhibit ClpXP and Attenuate Staphylococcus aureus α‐Hemolysin Secretion

  2022cites this paper
• Cellular functions of the ClpP protease impacting bacterial virulence

  2022cites this paper
• Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction.

  2021cites this paper
• Four-membered ring systems

  2021cites this paper
• Recent advances in Clp protease modulation to address virulence, resistance and persistence of MRSA infection.

  2021cites this paper
• Chemical tools for selective activity profiling of bacterial penicillin-binding proteins.

  2020cites this paper
• Profiling of Haemophilus influenzae strain R2866 with carbohydrate-based covalent probes.

  2020cites this paper
• Rings of Power: Enzymatic Routes to β-Lactones

  2020cites this paper
• Global Inventory of ClpP- and ClpX-Regulated Proteins in Staphylococcus aureus.

  2020cites this paper
• ClpXP Protease Networks studied by Chemical Cross-Linking Combined with Mass Spectrometry – A Proteomic Survey on Human Pyridoxal 5’-Phosphate-Binding Proteins

  2019influential citation
• Biosynthesis and chemical diversity of β-lactone natural products.

  2019cites this paper
• Chemical Cross-Linking Enables Drafting ClpXP Proximity Maps and Taking Snapshots of In Situ Interaction Networks.

  2019cites this paper
• Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.

  2019cites this paper
• Mitochondria in Health and in Sickness

  2019influential citation
• Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics.

  2019cites this paper
• Über bisherige Denkweisen hinaus - neue Wirkstoffe zur Überwindung der Antibiotika-Krise

  2018cites this paper
• Sample Preparation by Easy Extraction and Digestion (SPEED) - A Universal, Rapid, and Detergent-free Protocol for Proteomics Based on Acid Extraction*

  2018cites this paper
• Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis.

  2018cites this paper
• A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus.

  2017cites this paper
• Verringerung der Virulenz von multiresistentem Staphylococcus aureus mithilfe eines chemischen Disruptors des ClpX‐Chaperon‐Komplexes

  2017cites this paper