Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  International Journal of Molecular Medicine

• Publication date

  2018-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3892/ijmm.2018.3568PMID 29568880
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells

  2017cited by this paper
• Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells

  2017cited by this paper
• Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

  2017cited by this paper
• Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

  2017cited by this paper
• PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis

  2017cited by this paper
• Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway

  2016cited by this paper
• Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

  2015cited by this paper
• Statin use and mortality in cancer patients: Systematic review and meta-analysis of observational studies.

  2015cited by this paper
• Simvastatin reverses cardiomyocyte hypertrophy via the upregulation of phosphatase and tensin homolog expression.

  2015cited by this paper
• Phosphatidylinositol 3-kinase (PI3K) signalling regulates insulin-like-growth factor binding protein-2 (IGFBP-2) production in human adipocytes.

  2015cited by this paper
• Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies

  2014cited by this paper
• Non-cardiovascular effects associated with statins

  2014cited by this paper
• Rosiglitazone Regulates Anti-Inflammation and Growth Inhibition via PTEN

  2014cited by this paper
• Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT/mTOR, ERK and JAK2/STAT3 Pathway

  2013influential reference
• Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions.

  2013influential reference
• Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology

  2013cited by this paper
• Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-cell homeostasis in patients with PTEN hamartoma tumor syndrome.

  2012cited by this paper
• Statin use and reduced cancer-related mortality.

  2012cited by this paper
• Lifetime Cancer Risks in Individuals with Germline PTEN Mutations

  2012cited by this paper
• Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

  2011cited by this paper
• Oral rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation

  2011cited by this paper
• PTEN loss in the continuum of common cancers, rare syndromes and mouse models

  2011cited by this paper
• Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells.

  2010cited by this paper
• Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.

  2010cited by this paper
• Impact of simvastatin on adipose tissue: pleiotropic effects in vivo.

  2009cited by this paper
• Rapamycin treatment for a child with germline PTEN mutation

  2008cited by this paper
• Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa.

  2008cited by this paper
• Dramatic reduction in lipoma associated with statin therapy.

  2008cited by this paper
• Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

  2008cited by this paper
• Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways.

  2006cited by this paper
• Peroxisomal proliferator-activated receptor-gamma agonists induce partial reversion of epithelial-mesenchymal transition in anaplastic thyroid cancer cells.

  2006cited by this paper
• Breast cancer growth prevention by statins.

  2006influential reference
• Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells.

  2005cited by this paper
• Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts.

  2005cited by this paper
• PTEN: One Gene, Many Syndromes

  2003cited by this paper
• Activation of PPARgamma increases PTEN expression in pancreatic cancer cells.

  2003cited by this paper
• Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study.

  2001cited by this paper
• Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

  2001cited by this paper
• Simvastatin: A Review of its Pharmacology and Clinical Use

  1991cited by this paper

• Simvastatin Induces Apoptosis And Suppresses Hepatocellular Carcinoma Induced In Rats

  2022cites this paper
• The potential use of simvastatin for cancer treatment: A review.

  2021cites this paper
• PTEN regulates adipocyte progenitor growth, differentiation and replicative aging

  2021cites this paper
• PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging

  2021cites this paper
• Surgical excision of complex lipoma from the foot: A case report

  2020cites this paper
• Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity

  2020cites this paper
• A new human adipocyte model with PTEN haploinsufficiency

  2020cites this paper
• Effects of statins on brain tumors: a review.

  2020cites this paper
• The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells

  2019cites this paper
• Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

  2019cites this paper
• Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

  2019cites this paper
• binding protein-2 (IGFBP-2) production in human adipocytes. Growth Horm IGF

  year unknowncites this paper