Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Pharmacology and Therapeutics

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0163-7258(02)00192-4PMID 12191615
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin‐linked kinase, ILK1

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• Integrin-linked Kinase (ILK) Binding to Paxillin LD1 Motif Regulates ILK Localization to Focal Adhesions*

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• Ca2+-independent Smooth Muscle Contraction

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• Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

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• The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

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• Colocalization and Redistribution of Dishevelled and Actin during WNT-Induced Mesenchymal Morphogenesis

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• The integrin-linked kinase (ILK) suppresses anoikis

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• The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)

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  1999cited by this paper
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• Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats.

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• A Novel Muscle-Specific β1 Integrin Binding Protein (Mibp) That Modulates Myogenic Differentiation

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• Regulation of matrix metalloproteinase expression in tumor invasion

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• PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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• Intact LIM 3 and LIM 4 Domains of Paxillin Are Required for the Association to a Novel Polyproline Region (Pro 2) of Protein-Tyrosine Phosphatase-PEST*

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• The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

  1999influential reference
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  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
• CREB Is a Regulatory Target for the Protein Kinase Akt/PKB*

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression*

  1997cited by this paper
• Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4.

  1997cited by this paper
• Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

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• Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

  1996influential reference
• A new LIM protein containing an autoepitope homologous to "senescent cell antigen".

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• Signal transduction and regulation in smooth muscle

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• Integrins: versatility, modulation, and signaling in cell adhesion.

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  2022cites this paper
• Methods to Study Posttranslational Modification Patterns in Cytotoxic T-Cells and Cancer.

  2021cites this paper
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  2021influential citation
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  2020cites this paper
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  2018cites this paper
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  2016cites this paper
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  2015cites this paper
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  2011cites this paper
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