Adenovirus-Mediated TRAIL Gene (Ad5hTRAIL) Delivery into Pancreatic Islets Prolongs Normoglycemia in Streptozotocin-Induced Diabetic Rats

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Human Gene Therapy

• Publication date

  2009-08-18

• Fields of study

  Medicine

• Identifiers
  DOI 10.1089/hum.2009.039PMID 19572802
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In Vivo Fluorescence Imaging is Well-Suited for the Monitoring of Adenovirus Directed Transgene Expression in Living Organisms

  2010cited by this paper
• High TRAIL Death Receptor 4 and Decoy Receptor 2 Expression Correlates With Significant Cell Death in Pancreatic Ductal Adenocarcinoma Patients

  2009cited by this paper
• TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.

  2008cited by this paper
• The death ligand TRAIL in diabetic nephropathy.

  2008cited by this paper
• Genetic manipulation of islet cells in autoimmune diabetes: from bench to bedside.

  2008cited by this paper
• The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

  2008cited by this paper
• High Levels of Endogenous Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression Correlate With Increased Cell Death in Human Pancreas

  2008cited by this paper
• Molecular mechanisms of death ligand‐mediated immune modulation: A gene therapy model to prolong islet survival in type 1 diabetes

  2008cited by this paper
• Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.

  2007cited by this paper
• Concurrent gene therapy strategies effectively destroy synoviocytes of patients with rheumatoid arthritis.

  2007cited by this paper
• TRAIL death receptor-4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma.

  2007cited by this paper
• Pleiotropic functions of TNF-α determine distinct IKKβ-dependent hepatocellular fates in response to LPS

  2007influential reference
• Differential expression of TRAIL and its receptors in benign and malignant prostate tissues.

  2007cited by this paper
• Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.

  2006cited by this paper
• Adenovirus-mediated IKKβKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis

  2006cited by this paper
• Diabetes cure--is the glass half full?

  2006cited by this paper
• Gene therapy for type 1 diabetes: is it ready for the clinic?

  2006influential reference
• Adenoviral overexpression of interleukin-1 receptor antagonist protein increases β-cell replication in rat pancreatic islets

  2005cited by this paper
• Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis.

  2005cited by this paper
• TRAIL-Transduced Dendritic Cells Protect Mice from Acute Graft-versus-Host Disease and Leukemia Relapse1

  2005cited by this paper
• Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and CD56 Expression in Patients With Type 1 Diabetes Mellitus

  2005cited by this paper
• Strategic opportunities in clinical islet transplantation.

  2005cited by this paper
• Inhibition of the NF-κB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells

  2004cited by this paper
• Fundamental principals of tumor necrosis factor-alpha gene therapy approach and implications for patients with lung carcinoma.

  2004influential reference
• Gene-altered islets for transplant: giant leap or small step?

  2004cited by this paper
• Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis.

  2003influential reference
• Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.

  2003cited by this paper
• Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes.

  2003cited by this paper
• First-Generation Adenovirus Vectors Shorten Survival Time in a Murine Model of Sepsis1

  2002cited by this paper
• TNF-Related Apoptosis-Inducing Ligand Death Pathway-Mediated Human Beta-Cell Destruction

  2002cited by this paper
• Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFα-mediated apoptosis

  2001cited by this paper
• Adeno-associated virus (AAV) as a vehicle for therapeutic gene delivery: improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes.

  2001cited by this paper
• A Dual Role for TNF-α in Type 1 Diabetes: Islet-Specific Expression Abrogates the Ongoing Autoimmune Process When Induced Late but Not Early During Pathogenesis1

  2001cited by this paper
• Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors.

  2001cited by this paper
• The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.

  2000cited by this paper
• Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Is an Inhibitor of Autoimmune Inflammation and Cell Cycle Progression

  2000cited by this paper
• Adenoviral-Mediated Transfer of the TNF-Related Apoptosis-Inducing Ligand/Apo-2 Ligand Gene Induces Tumor Cell Apoptosis1

  2000cited by this paper
• Functional analysis of TRAIL receptors using monoclonal antibodies.

  1999cited by this paper
• Apoptosis control by death and decoy receptors.

  1999cited by this paper
• TRAIL: a molecule with multiple receptors and control mechanisms.

  1998cited by this paper
• Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens.

  1998cited by this paper
• Adenovirus-Mediated Expression of Fas Ligand Induces Hepatic Apoptosis after Systemic Administration and Apoptosis of Ex Vivo-Infected Pancreatic Islet Allografts and Isografts

  1997cited by this paper
• Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

  1997cited by this paper
• Solitary pancreas transplantation for nonuremic patients with labile insulin-dependent diabetes mellitus.

  1997cited by this paper
• Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

  1996cited by this paper
• Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

  1996cited by this paper
• Identification and characterization of a new member of the TNF family that induces apoptosis.

  1995cited by this paper
• Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

  1993cited by this paper
• Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

  1993cited by this paper
• Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes

  1992cited by this paper
• Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

  1967cited by this paper

• Lantidra (donislecel) in type 1 diabetes: An in‐depth analysis of pharmacology, clinical effectiveness, safety, and the therapeutic role of the first FDA‐approved allogeneic islet cell therapy

  2025cites this paper
• Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes

  2024cites this paper
• Gene and cell therapy of human genetic diseases: Recent advances and future directions

  2024cites this paper
• Heme oxygenase-1 gene delivery for altering high mobility group box-1 protein in pancreatic islet.

  2022cites this paper
• Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology.

  2022cites this paper
• Repositioning the Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) on the TRAIL to the Development of Diabetes Mellitus: An Update of Experimental and Clinical Evidence

  2022cites this paper
• Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway

  2022cites this paper
• TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation.

  2021influential citation
• TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake

  2021cites this paper
• Pancreatic islet cell transplantation

  2020influential citation
• Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation

  2020cites this paper
• Expression profiles of TRAIL and its receptors in normal, hyperplastic, and malignant endometrial tissues: Hints on endometrial cancer biology

  2019cites this paper
• TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?

  2019cites this paper
• Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes

  2018cites this paper
• HIV-based lentivirus-mediated vasoactive intestinal peptide gene delivery protects against DIO animal model of Type 2 diabetes

  2018cites this paper
• TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies.

  2018cites this paper
• Gene delivery to pancreatic islets for effective transplantation in diabetic animal

  2017cites this paper
• Beta Cell Therapies for Type 1 Diabetes

  2016cites this paper
• Harnessing immune cells to enhance β-cell mass in type 1 diabetes

  2016cites this paper
• [Viral transfer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gene therapy].

  2015cites this paper
• The effect of bariatric surgery on serum TRAIL and osteoprotegerin levels in obesity complicated by glucose disorders

  2014cites this paper
• GLP-1-mediated gene therapy approaches for diabetes treatment

  2014cites this paper
• Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma

  2013cites this paper
• On the TRAIL of obesity and diabetes.

  2013cites this paper
• Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer.

  2012cites this paper
• Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma

  2012cites this paper
• Apoptosis and Autoimmune Disorders

  2012cites this paper
• Therapeutic potential of VIP vs PACAP in diabetes.

  2012cites this paper
• Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer

  2011cites this paper
• TRAIL and DcR1 Expressions Are Differentially Regulated in the Pancreatic Islets of STZ- versus CY-Applied NOD Mice

  2011cites this paper
• TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe−/− mice

  2011cites this paper
• APO2L/TRAIL: new insights in the treatment of autoimmune disorders.

  2011cites this paper
• Tracing of islet graft survival by way of in vivo fluorescence imaging

  2011influential citation
• Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis

  2010cites this paper
• TRAIL Death Receptor-4, Decoy Receptor-1 and Decoy Receptor-2 Expression on CD8+ T Cells Correlate with the Disease Severity in Patients with Rheumatoid Arthritis

  2010cites this paper
• Treatment With Recombinant Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Alleviates the Severity of Streptozotocin-Induced Diabetes

  2010cites this paper