Dexmedetomidine enhances human lung fluid clearance through improving alveolar sodium transport

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Fundamental & Clinical Pharmacology

• Publication date

  2017-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/fcp.12278PMID 28186665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute Respiratory Distress Syndrome

  2016cited by this paper
• Dexmedetomidine attenuates acute lung injury induced by lipopolysaccharide in mouse through inhibition of MAPK pathway

  2015cited by this paper
• Dexmedetomidine alleviates pulmonary edema by upregulating AQP1 and AQP5 expression in rats with acute lung injury induced by lipopolysaccharide

  2015cited by this paper
• The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier.

  2014cited by this paper
• Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.

  2013cited by this paper
• Protective effect of dexmedetomidine in a rat model of α-naphthylthiourea-induced acute lung injury.

  2012cited by this paper
• Dexmedetomidine attenuates remote lung injury induced by renal ischemia‐reperfusion in mice

  2011cited by this paper
• 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels.

  2011cited by this paper
• Recurrent episodes of intractable laryngospasm followed by laryngeal and pulmonary oedema during dissociative anaesthesia with intravenous ketamine

  2010cited by this paper
• K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport

  2010cited by this paper
• Regulation of epithelial sodium channels by cGMP/PKGII

  2009cited by this paper
• Effect of PD98059, a Selective MAPK3/MAPK1 Inhibitor, on Acute Lung Injury in Mice

  2009cited by this paper
• Epithelial sodium channel regulated by differential composition of a signaling complex

  2009cited by this paper
• Dexmedetomidine, an alpha2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current.

  2009cited by this paper
• Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells.

  2009cited by this paper
• Ketamine and Pulmonary Oedema–Report of Two Cases

  2009cited by this paper
• Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.

  2007cited by this paper
• Dexmedetomidine-induced pulmonary alterations in sheep.

  2007cited by this paper
• Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates.

  2007cited by this paper
• Acute pulmonary edema after diazepam-ketamine in a dog.

  2007cited by this paper
• The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial.

  2006cited by this paper
• The β-agonist lung injury trial (BALTI) : A randomized placebo-controlled clinical trial

  2006cited by this paper
• Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine*

  2006cited by this paper
• Catecholamine Clearance from Alveolar Spaces of Rat and Human Lungs

  2005cited by this paper
• Alveolar epithelium: role in lung fluid balance and acute lung injury.

  2005cited by this paper
• Bench-to-bedside review: The role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury

  2004cited by this paper
• Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone.

  2003cited by this paper
• Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret.

  2002cited by this paper
• Lung epithelial fluid transport and the resolution of pulmonary edema.

  2002cited by this paper
• Lidocaine Induces a Reversible Decrease in Alveolar Epithelial Fluid Clearance in Rats

  2002cited by this paper
• Invited review: Active fluid clearance from the distal air spaces of the lung.

  2002cited by this paper
• Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells.

  2001cited by this paper
• Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome.

  2001cited by this paper
• The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans

  2000cited by this paper
• Fulminant pulmonary edema after intramuscular ketamine

  2000cited by this paper
• Cardiopulmonary Effects of the α2-Adrenoceptor Agonists Medetomidine and ST-91 in Anesthetized Sheep

  1999cited by this paper
• Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance.

  1999cited by this paper
• Acute respiratory distress syndrome

  1999cited by this paper
• Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells.

  1996cited by this paper
• International Union of Pharmacology nomenclature of adrenoceptors.

  1994cited by this paper
• The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.

  1994cited by this paper
• Hypertension and pulmonary oedema associated with ketamine administration in a patient with a history of substance abuse

  1993cited by this paper

• Role of biomarkers and molecular signaling pathways in acute lung injury

  2024cites this paper
• Perioperative fluid management for lung transplantation is challenging.

  2023cites this paper
• Bone marrow mesenchymal stem cell‐conditioned medium facilitates fluid resolution via miR‐214‐activating epithelial sodium channels

  2020cites this paper
• Sepsis-Induced Lung Injury: The Mechanism and Treatment

  2019cites this paper
• Geriatric Anesthesia-related Morbidity and Mortality in China: Current Status and Trend

  2017cites this paper