Oral Administration with Papillomavirus Pseudovirus Encoding IL-2 Fully Restores Mucosal and Systemic Immune Responses to Vaccinations in Aged Mice1

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Immunology

• Publication date

  2004-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.173.4.2692PMID 15294987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003cited by this paper
• APC-dependent impairment of T cell proliferation in aging: role of CD28- and IL-12/IL-15-mediated signaling.

  2002cited by this paper
• Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

  2002cited by this paper
• Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice.

  2002cited by this paper
• Cold-adapted live influenza vaccine versus inactivated vaccine: systemic vaccine reactions, local and systemic antibody response, and vaccine efficacy. A meta-analysis.

  2002cited by this paper
• Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly.

  2002cited by this paper
• Effect of aging on cytokine production in response to respiratory syncytial virus infection.

  2002cited by this paper
• Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets.

  2002cited by this paper
• The humoral response to live and inactivated influenza vaccines administered alone and in combination to young adults and elderly.

  2002cited by this paper
• Defective generation but normal maintenance of memory T cells in old mice

  2002cited by this paper
• Defective in vivo induction of functional type 2 cytokine responses in aged mice

  2001cited by this paper
• Effect of age on the gastrointestinal-associated mucosal immune response of humans.

  2001cited by this paper
• Papillomavirus Pseudovirus: a Novel Vaccine To Induce Mucosal and Systemic Cytotoxic T-Lymphocyte Responses

  2001cited by this paper
• Aging impairs intestinal immunity.

  2001cited by this paper
• Severe impairment of primary but not memory responses to influenza viral antigens in aged mice: costimulation in vivo partially reverses impaired primary immune responses.

  2001cited by this paper
• Altered T cell signalling in ageing.

  2001cited by this paper
• In Vitro Treatment with Interleukin-2 Normalizes Type-1 Cytokine Production by Lymphocytes from Elderly

  2000cited by this paper
• Evidence For Early Aging in the Mucosal Immune System1

  2000cited by this paper
• The defects in effector generation associated with aging can be reversed by addition of IL-2 but not other related gamma(c)-receptor binding cytokines.

  2000cited by this paper
• Immunity to influenza in the elderly.

  2000cited by this paper
• Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4+ and CD8+ T cells.

  2000cited by this paper
• Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice.

  2000cited by this paper
• Mucosal vaccination and immune responses in the elderly.

  2000cited by this paper
• NK and NK/T cells in human senescence.

  2000cited by this paper
• Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells.

  2000cited by this paper
• Age-Associated Changes in Interferon-γ and Interleukin-4 Secretion by Purified Human CD4+ and CD8+ T Cells

  2000influential reference
• Antigen presenting cell function is enhanced in healthy elderly.

  1999cited by this paper
• Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity.

  1999cited by this paper
• In vitro gene transfer using human papillomavirus-like particles.

  1998cited by this paper
• Impaired natural killer cell function as a consequence of aging.

  1998cited by this paper
• Is vaccination against human papillomavirus a possibility?

  1998cited by this paper
• Aging and the Immune Response to Tetanus Toxoid: Diminished Frequency and Level of Cellular Immune Reactivity to Antigenic Stimulation

  1998cited by this paper
• In Vitro Construction of Pseudovirions of Human Papillomavirus Type 16: Incorporation of Plasmid DNA into Reassembled L1/L2 Capsids

  1998cited by this paper
• Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice

  1997cited by this paper
• Effect of age on humoral immunity, selection of the B‐cell repertoire and B‐cell development

  1997cited by this paper
• Natural killer cell cytotoxicity in elderly humans after influenza immunization

  1996cited by this paper
• Impact of aging on gastrointestinal mucosal immunity

  1996cited by this paper
• Papillomavirus-like particles and HPV vaccine development.

  1996cited by this paper
• Assembly of the major and the minor capsid protein of human papillomavirus type 33 into virus-like particles and tubular structures in insect cells.

  1994cited by this paper
• Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine.

  1993cited by this paper
• Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles

  1993cited by this paper
• Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination.

  1993cited by this paper
• Heterotypic immune mice lose protection against influenza virus infection with senescence.

  1993cited by this paper
• In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women.

  1992cited by this paper
• Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.

  1992cited by this paper
• Cell proliferation and cytokine production by CD4+ cells from old mice

  1991cited by this paper
• Immune-related alterations in aged gut-associated lymphoid tissues in mice

  1989cited by this paper
• Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus.

  1988cited by this paper
• Reconstitution of in vivo cell-mediated lympholysis responses in aged mice with interleukin 2.

  1985cited by this paper
• General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes

  1984cited by this paper
• Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans.

  1980cited by this paper

• Mucosal Vaccines for Aged: Challenges and Struggles in Immunosenescence

  2020cites this paper
• Gene Therapy and Immunosenescence

  2019cites this paper
• Mucosal Vaccination Challenges in Aging: Understanding Immunosenescence in the Aerodigestive Tract

  2019cites this paper
• [Experimental research on Arginine-gingipain A gene vaccine from Porphyromonas gingivalis that prevents peri-implantitis in Beagle dogs].

  2018cites this paper
• Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments

  2017cites this paper
• A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly

  2015cites this paper
• Compartmentalization of immunosenescence: a deeper look at the mucosa

  2015cites this paper
• A targeted fimA DNA vaccine prevents alveolar bone loss in mice after intra-nasal administration.

  2011cites this paper
• Both Systemic and Mucosal LCMV Immunization Generate Robust Viral-Specific IgG in Mucosal Secretions, But Elicit Poor LCMV-Specific IgA

  2010cites this paper
• WITHDRAWN: Enhancing efficacy and mucosa-tropic distribution of an oral HIV-PsV DNA vaccine in animal models

  2010cites this paper
• Gene Therapy and Immune Senescence

  2009cites this paper
• Biological gene delivery vehicles: beyond viral vectors.

  2009cites this paper
• Mucosal immunosenescence: new developments and vaccines to control infectious diseases.

  2009cites this paper
• RETRACTED: Enhancing efficacy and mucosa-tropic distribution of an oral HIV-PsV DNA vaccine in animal models

  2009cites this paper
• Inhibition of cervical cancer cell growth by human papillomavirus virus–like particles packaged with human papillomavirus oncoprotein short hairpin RNAs

  2009cites this paper
• Aging and HIV Disease: Synergistic Immunological Effects?

  2009cites this paper
• Induction of antibody response against hepatitis E virus (HEV) with recombinant human papillomavirus pseudoviruses expressing truncated HEV capsid proteins in mice.

  2008cites this paper
• Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles

  2007cites this paper
• Live Attenuated Influenza Virus Expressing Human Interleukin-2 Reveals Increased Immunogenic Potential in Young and Aged Hosts (cid:1)

  2006cites this paper
• Papillomavirus virus-like particles as vehicles for the delivery of epitopes or genes

  2006cites this paper
• Long-term gene expression in dividing and nondividing cells using SV40-derived vectors

  2006cites this paper
• Live Attenuated Influenza Virus Expressing Human Interleukin-2 Reveals Increased Immunogenic Potential in Young and Aged Hosts

  2006cites this paper
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  2005cites this paper
• Efficacy of rotavirus-like particle vaccines and pathogenesis of human rotavirus evaluated in a gnotobiotic pig model

  2005cites this paper
• Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway.

  2005cites this paper
• Induction of mucosal and systemic immune responses against human carcinoembryonic antigen by an oral vaccine.

  2005cites this paper