Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Experimental biology and medicine

• Publication date

  2018-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/1535370218757950PMID 29444596PMCID PMC5882028
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

  2017cited by this paper
• Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?

  2017cited by this paper
• Analysis of natural product regulation of opioid receptors in the treatment of human disease.

  2017cited by this paper
• Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease.

  2017cited by this paper
• Cellular senescence in osteoarthritis pathology

  2017cited by this paper
• Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

  2015cited by this paper
• Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

  2015cited by this paper
• Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

  2015cited by this paper
• Physical activity ameliorates cartilage degeneration in a rat model of aging: A study on lubricin expression

  2015cited by this paper
• Cytokines as biochemical markers for knee osteoarthritis.

  2015cited by this paper
• Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes.

  2015cited by this paper
• Pinocembrin inhibits matrix metalloproteinase expression in chondrocytes

  2015cited by this paper
• Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis.

  2015cited by this paper
• Regulation of inflammation by cannabinoids, the endocannabinoids 2‐arachidonoyl‐glycerol and arachidonoyl‐ethanolamide, and their metabolites

  2015cited by this paper
• Dimethyl fumarate protection against collagen II degradation.

  2014cited by this paper
• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

  2014cited by this paper
• The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

  2014cited by this paper
• p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

  2014cited by this paper
• Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes.

  2014cited by this paper
• The Age-Related Changes in Cartilage and Osteoarthritis

  2013cited by this paper
• Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

  2013cited by this paper
• Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).

  2013cited by this paper
• Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate

  2013cited by this paper
• In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis.

  2012cited by this paper
• Cannabinoids: novel therapies for arthritis?

  2012cited by this paper
• DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes.

  2012cited by this paper
• Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

  2011cited by this paper
• Biological actions of curcumin on articular chondrocytes.

  2010cited by this paper
• Why is osteoarthritis an age-related disease?

  2010cited by this paper
• SIRT1 regulation of apoptosis of human chondrocytes.

  2009cited by this paper
• Angiogenic growth factors inhibit chondrocyte ageing in osteoarthritis: potential involvement of catabolic stress‐induced overexpression of caveolin‐1 in cellular ageing

  2009cited by this paper
• Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

  2008cited by this paper
• Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration

  2008cited by this paper
• Sirt1 modulates premature senescence-like phenotype in human endothelial cells.

  2007cited by this paper
• Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis.

  2006cited by this paper
• Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro

  2006cited by this paper
• Cell death in cartilage.

  2004cited by this paper
• Mechanisms of cellular senescence in human and mouse cells

  2004cited by this paper
• 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain.

  1995cited by this paper

• SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation

  2025cites this paper
• The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review

  2025cites this paper
• Single-cell RNA sequencing generates an atlas of normal tibia cartilage under mechanical loading conditions

  2025cites this paper
• Sirt1 Mitigates HT-2 Toxin-Induced Chondrocyte Injury Potentially via the Wnt/β-Catenin Signaling Pathway.

  2025cites this paper
• Arachidonoylethanolamide promotes cellular senescence in a human glioblastoma cell line.

  2024cites this paper
• Amide Alkaloids as Privileged Sources of Senomodulators for Therapeutic Purposes in Age-Related Diseases.

  2024cites this paper
• Effects of Tocilizumab on Intervertebral Disc Degeneration, Cell Senescence and Inflammation via BMP-2, Hif-1α , IL-1β and SOX9

  2023cites this paper
• CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway

  2022cites this paper
• G Protein-Coupled Receptors in Osteoarthritis

  2022cites this paper
• Adipose mesenchymal stem cells and gingival mesenchymal stem cells have a comparable effect in endothelium repair

  2021cites this paper
• The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis

  2020cites this paper
• The protective role of omentin-1 in IL-1β-induced chondrocyte senescence

  2020cites this paper
• The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis

  2020cites this paper
• Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent

  2020cites this paper
• miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence

  2019cites this paper