Arterial stiffness as a model to dissect chronic inflammation in FMF

Background Familial Mediterranean fever (FMF) is an autoinflammatory disorder, characterized by short attacks of sterile serositis, successfully suppressed by continuous colchicine treatment. Subclinical chronic inflammation however, is a frequent finding in FMF, manifested with elevated levels of inflammatory markers (CRP, SAA). While chronic inflammation is considered an important cardiovascular (CV) risk factor in most inflammatory disorders, findings on the impact of chronic inflammation in FMF are conflicting. Chronic inflammation is an important cause of arterial stiffness, an early sign and independent risk factor of cardiovascular atherosclerosis. Pulse wave velocity (PWV) measurement is a useful marker of arterial stiffness.

• Publication year

  2015

• Venue

  Pediatric Rheumatology Online Journal

• Publication date

  2015-09-28

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1186/1546-0096-13-S1-P93PMCID 4599843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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• No concepts are published for this paper.

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