Aging impairs induction of cyclin-dependent kinases and down-regulation of p27 in mouse CD4(+) cells.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cellular Immunology

• Publication date

  1999-11-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/CIMM.1999.1573PMID 10612647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GATA-1 Dominantly Activates a Program of Erythroid Gene Expression in Factor-Dependent Myeloid FDCW2 Cells

  1998cited by this paper
• Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.

  1998cited by this paper
• Age-associated decline in cdk1 activity delays cell cycle progression of human T lymphocytes.

  1998cited by this paper
• Increased Zap-70 association with CD3zeta in CD4 T cells from old mice.

  1998cited by this paper
• DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?

  1998cited by this paper
• Helper T cell differentiation is controlled by the cell cycle.

  1998cited by this paper
• The regulation of p27Kip1 expression following the polyclonal activation of murine G0 T cells.

  1997cited by this paper
• Clues to immune function and oncogenesis provided by events that activate the cell cycle machinery in normal human T cells

  1997cited by this paper
• New functional activities for the p21 family of CDK inhibitors.

  1997cited by this paper
• Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice.

  1997cited by this paper
• Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age.

  1997cited by this paper
• Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F.

  1997cited by this paper
• Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

  1997cited by this paper
• Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4*

  1997cited by this paper
• TCR-mediated death of mature T lymphocytes occurs in the absence of p53.

  1996cited by this paper
• Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo.

  1996cited by this paper
• Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.

  1996cited by this paper
• A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.

  1996cited by this paper
• Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

  1996cited by this paper
• Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1.

  1996cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Cytokine production by T lymphocytes from young and aged mice.

  1996cited by this paper
• The Aging Immune System: Primer and Prospectus

  1996cited by this paper
• Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

  1996cited by this paper
• Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging.

  1995cited by this paper
• Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging.

  1995cited by this paper
• Symmetry of the Activation of Cyclin‐dependent Kinases in Mitogen and Growth Factor‐stimulated T Lymphocytes a

  1995cited by this paper
• Principles of CDK regulation

  1995cited by this paper
• Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.

  1995cited by this paper
• Differential regulation of the synthesis and activity of the major cyclin‐dependent kinases, p34cdc2, p33cdk2, and p34cdk4, during cell cycle entry and progression in normal human T lymphocytes

  1995cited by this paper
• Inhibition of cyclin-dependent kinases by p21.

  1995cited by this paper
• Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes

  1994cited by this paper
• lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

  1994cited by this paper
• The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

  1994cited by this paper
• Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

  1993cited by this paper
• Mammalian G1 cyclins.

  1993cited by this paper
• Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

  1992cited by this paper
• The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

  1992cited by this paper
• Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice.

  1992cited by this paper
• The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

  1991cited by this paper
• Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs.

  1991cited by this paper
• Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

  1991cited by this paper
• T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.

  1990cited by this paper
• Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link.

  1990cited by this paper
• Molecular events mediating T cell activation.

  1990cited by this paper
• In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase.

  1989cited by this paper
• The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.

  1989cited by this paper
• The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.

  1989cited by this paper
• Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.

  1989cited by this paper
• Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product.

  1989cited by this paper
• Diminished calcium influx in lectin‐stimulated T cells from old mice

  1987cited by this paper
• Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

  1985cited by this paper
• BrdU‐Hoechst flow cytometry reveals regulation of human lymphocyte growth by donor‐age–related growth fraction and transition rate

  1985cited by this paper
• Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

  1985cited by this paper
• Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry.

  1984cited by this paper
• Limiting dilution analysis of alloreactive cytotoxic precursor cells in aging mice.

  1983cited by this paper
• The role of calcium in lymphocyte proliferation. (An interpretive review).

  1983cited by this paper
• The role of calcium in lymphocyte proliferation. (An interpretive review)

  1983cited by this paper
• Age-related effects on the number of human lymphocytes in culture initially responding to an antigenic stimulus.

  1982cited by this paper

• Can the Immune System Still Be Efficient in the Elderly? An Immunological and Immunoendocrine Therapeutic Perspective

  2008cites this paper
• Deoxynivalenol alters circulating and splenic leukocytes and cell migration markers in interaction with time course and sex in young and old BALB/c mice

  2008cites this paper
• A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma

  2006cites this paper
• Paradoxical age-related cell cycle quickening of human CD4(+) lymphocytes: a role for cyclin D1 and calpain.

  2004cites this paper
• T Cell Immunosenescence

  2003cites this paper
• T cells and aging, January 2002 update.

  2002cites this paper
• Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells.

  2001cites this paper
• The center for multidisciplinary research in aging (CMRA) at Ben Gurion University of the Negev in Israel.

  2001cites this paper
• Cell-cycle regulation in immunity, tolerance and autoimmunity.

  2000cites this paper
• Anti-Aging Medicine LiteratureWatch

  1998cites this paper