Assessment of Plasma S-Nitrosothiol Concentration by Electron Paramagnetic Resonance Spectrometry and Plasma Nitrotyrosine Levels by ELISA in Behçet’s Disease

Yasemin Akçay,Iona Knight,E. L. Taylor,K. Aksu,Paul G. Winyard

Published 2007 in EJIFCC

ABSTRACT

Although the exact underlying mechanism of BD is still unknown, recent findings have focused on the role of reactive oxygen species (ROS) produced by activated neutrophils and other inflammatory cells during inflammation (4,5). Recently, it has been also shown that nitrite and nitrate concentrations, used as indirect markers of nitric oxide (NO) production are increased in BD patients and associated with disease activity (6,7,8). NO produced by endothelial cells may be an important mediator in the development of BD.

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