Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Experimental biology and medicine

• Publication date

  2012-07-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1258/ebm.2012.011396PMID 22859739
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of environmental exposures in neurodegeneration and neurodegenerative diseases.

  2011cited by this paper
• Review on metal speciation analysis in cerebrospinal fluid-current methods and results: a review.

  2010cited by this paper
• Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis.

  2009cited by this paper
• Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

  2009cited by this paper
• Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.

  2008cited by this paper
• Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

  2008cited by this paper
• Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier.

  2008cited by this paper
• Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI.

  2008cited by this paper
• Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron.

  2008cited by this paper
• Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.

  2008cited by this paper
• Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and peripheral demyelinating disease.

  2008cited by this paper
• Are metallothionein genes silenced in ALS?

  2007cited by this paper
• Changes in Blood Manganese Concentration and MRI T1 Relaxation Time During 180 Days of Stainless Steel Welding-Fume Exposure in Cynomolgus Monkeys

  2007cited by this paper
• Speciation and toxicological relevance of manganese in humans.

  2007cited by this paper
• Putative proteins involved in manganese transport across the blood-brain barr 1ier

  2007cited by this paper
• Manganese, copper, and zinc in cerebrospinal fluid from patients with multiple sclerosis

  2007cited by this paper
• Manganese: recent advances in understanding its transport and neurotoxicity.

  2007cited by this paper
• Itraconazole

  2007cited by this paper
• Separation of proteins including metallothionein in cerebrospinal fluid by size exclusion HPLC and determination of trace elements by HR-ICP-MS.

  2007cited by this paper
• Metals in Motor Neuron Diseases

  2006cited by this paper
• Manganese

  2006cited by this paper
• [Electrodiagnosis of ALS].

  2006cited by this paper
• Functional and morphometric study of the liver in motor neuron disease

  2004cited by this paper
• Determination of low-abundance elements at ultra-trace levels in urine and serum by inductively coupled plasma–sector field mass spectrometry

  2004cited by this paper
• Manganese toxicokinetics at the blood-brain barrier.

  2004cited by this paper
• Whole blood manganese correlates with high signal intensities on T1-weighted MRI in patients with liver cirrhosis.

  2003cited by this paper
• Brain barrier systems: a new frontier in metal neurotoxicological research.

  2003cited by this paper
• Toxicological aspects of metallothionein.

  2000cited by this paper
• Consensus guidelines for the design and implementation of clinical trials in ALS. World Federation of Neurology committee on Research.

  1999cited by this paper
• Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease

  1998cited by this paper
• Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease

  1998cited by this paper
• Essential trace element alterations in amyotrophic lateral sclerosis.

  1997cited by this paper
• Astrocyte Metallothioneins (MTs) and Their Neuroprotective Role a

  1997cited by this paper
• Metallothionein in amyotrophic lateral sclerosis.

  1994cited by this paper
• Increased metallothionein in the liver and kidney of patients with amyotrophic lateral sclerosis.

  1992cited by this paper
• Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.

  1991cited by this paper
• Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis.

  1987cited by this paper
• Hepatic ultrastructural change and liver dysfunction in amyotrophic lateral sclerosis.

  1987cited by this paper
• Increased manganese level in spinal cords of amyotrophic lateral sclerosis determined by radiochemical neutron activation analysis.

  1983cited by this paper
• The pathogenesis of amyotrophic lateral sclerosis.

  1972cited by this paper
• State of Binding of Natural Manganese in Human Cerebrospinal Fluid, Blood and Plasma

  1962cited by this paper
• Nonparametric Statistics for the Behavioral Sciences

  1959cited by this paper

• Trace metal signatures in cerebrospinal fluid (CSF): Insights from an amyotrophic lateral sclerosis (ALS) hotspot on Mount Etna (Sicily, Italy).

  2026cites this paper
• Metals in Neurological Disorders: From Essential Functions to Toxicity, Epidemiology, and Therapeutic Prospects for Brain Health

  2025cites this paper
• Advances in Research on Neurotoxicity and Mechanisms of Manganese, Iron, and Copper Exposure, Alone or in Combination

  2025cites this paper
• Exploring antioxidant strategies in the pathogenesis of ALS

  2024cites this paper
• Dysautonomia in Amyotrophic Lateral Sclerosis

  2023cites this paper
• IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion

  2023cites this paper
• Metal ratios as possible biomarkers for amyotrophic lateral sclerosis.

  2023cites this paper
• The use of local materials to remove heavy metals for household-scale drinking water treatment: A review

  2023cites this paper
• Signaling Pathways Involved in Manganese-Induced Neurotoxicity

  2023cites this paper
• Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

  2022cites this paper
• A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk

  2022cites this paper
• Manganese

  2022cites this paper
• The cGAS-STING-autophagy pathway: Novel perspectives in neurotoxicity induced by manganese exposure.

  2022cites this paper
• Geochemistry of multiple sclerosis in Finland.

  2022cites this paper
• Exposing the role of metals in neurological disorders: a focus on manganese.

  2022cites this paper
• BTBD9 attenuates manganese induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway.

  2022cites this paper
• Simultaneous Quantification and Speciation of Trace Metals in Paired Serum and CSF Samples by Size Exclusion Chromatography–Inductively Coupled Plasma–Dynamic Reaction Cell–Mass Spectrometry (SEC-DRC-ICP-MS)

  2021cites this paper
• Metals in ALS TDP-43 Pathology

  2021cites this paper
• Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

  2021cites this paper
• Neuroprotective effects of disubstituted dithiolethione ACDT against manganese-induced toxicity in SH-SY5Y cells.

  2021cites this paper
• A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications.

  2020cites this paper
• The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis.

  2020cites this paper
• CSF neurotoxic metals/metalloids levels in amyotrophic lateral sclerosis patients: comparison between bulbar and spinal onset.

  2020cites this paper
• Localization of ZIP14 and ZIP8 in HIBCPP Cells

  2020influential citation
• Amyotrophic Lateral Sclerosis After Exposure to Manganese from Traditional Medicine Procedures in Kenya

  2020cites this paper
• Manganese-induced neurodegenerative diseases and possible therapeutic approaches

  2020cites this paper
• Application of the Ionomic Strategy to Evaluate Difference in Metal Ion Concentration Between Patients with Bipolar Disorder and Other Psychiatric Disorder

  2019cites this paper
• Ultraclean paired sampling for metal analysis in neurodegenerative disorders.

  2019cites this paper
• Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans.

  2019cites this paper
• Looking for the Missing Link: Application of Copper Isotope Metallomics to Amyotrophic Lateral Sclerosis

  2018cites this paper
• Trace elements in ALS patients and their relationships with clinical severity.

  2018cites this paper
• Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

  2018cites this paper
• Rehabilitation Models Of Mechanisms, Preventions And Treatments Of Amyotrophic Lateral Sclerosis Caused By Toxic Invasions

  2018cites this paper
• Risk Factors in Amyotrophic Lateral Sclerosis

  2018cites this paper
• In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1G93A ALS rat model☆

  2017cites this paper
• Motoneuron Disease: Basic Science.

  2017cites this paper
• Metals and Motor Neuron Disease

  2017cites this paper
• Metals and neurodegenerative diseases. A systematic review

  2017cites this paper
• Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders.

  2017cites this paper
• The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: a possible pathogenic role of volcanogenic metals

  2016cites this paper
• Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species

  2016cites this paper
• Does Glyphosate Acting as a Glycine Analogue Contribute To ALS

  2016cites this paper
• Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer's disease.

  2016cites this paper
• Autism, Chemicals, Probable Cause and Mitigation: A New Examination

  2016cites this paper
• Fisiopatologia de l'esclerosi lateral amiotròfica

  2015cites this paper
• Neuroimaging identifies increased manganese deposition in infants receiving parenteral nutrition.

  2015cites this paper
• [Amyotrophic lateral sclerosis and exposure to metals and other occupational/environmental hazardous materials: state of the art].

  2015cites this paper
• Urgent need to reevaluate the latest World Health Organization guidelines for toxic inorganic substances in drinking water

  2015cites this paper
• Risk factors for amyotrophic lateral sclerosis

  2015cites this paper
• AUTHOR PROOF COPY Not for publication

  2014cites this paper
• Table S1: Detailed overview of alterations in biometals across neurological disorders (*conflicting data). PIXE: Particle Induced X- ray Emission; XFM: X-ray Fluorescence microprobe imaging; XRF: X-Ray Fluorescence Spectroscopy; WB: Western Blot; ICP: Inductively Coupled Plasma Mass Spectrometry; IN

  2014cites this paper
• Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients: Does Aluminum Have an Influence?

  2014cites this paper
• Characterization of biometal profiles in neurological disorders.

  2014cites this paper
• A zebrafish model of manganism reveals reversible and treatable symptoms that are independent of neurotoxicity

  2014cites this paper
• Studies on metals in motor neuron disease

  2013cites this paper
• Relationship between soil contents and plasma levels of selenium, chromium and manganese in healthy adult Nigerians

  2013cites this paper
• Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

  2012cites this paper