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Adherence to the Mediterranean Diet Is not Related to Beta-Amyloid Deposition: Data from the Women's Healthy Ageing Project

Edward Hill,C. Szoeke,L. Dennerstein,S. Campbell,P. Clifton

Published 2018 in The journal of prevention of Alzheimer's disease

ABSTRACT

BackgroundResearch has indicated the neuroprotective potential of the Mediterranean diet. Adherence to the Mediterranean diet has shown preventative potential for Alzheimer’s disease incidence and prevalence, yet few studies have investigated the impact of Mediterranean diet adherence on the hallmark protein; beta-amyloid.ObjectivesTo investigate the association between Mediterranean diet adherence and beta-amyloid deposition in a cohort of healthy older Australian women.DesignThis study was a cross-sectional investigation of participants from the longitudinal, epidemiologically sourced Women’s Healthy Ageing Project which is a follow-up of the Melbourne Women’s Midlife Health Project.SettingAssessments were conducted at the Centre for Medical Research, Royal Melbourne Hospital in Melbourne, Australia. F-18 Florbetaben positron emission tomography scanning was conducted at the Austin Centre for PET in Victoria, Australia.ParticipantsOne hundred and eleven Women’s Healthy Ageing Project participants were included in the study.MeasurementsMediterranean diet adherence scores for all participants were calculated from the administration of a validated food frequency questionnaire constructed by the Cancer Council of Victoria. Beta-amyloid deposition was measured using positron emission tomography standardised uptake value ratios.ResultsGamma regression analysis displayed no association between Mediterranean diet adherence and beta-amyloid deposition. This result was consistent across APOE-ε4 +/- cohorts and with the inclusion of covariates such as age, education, body mass index and cognition.ConclusionsThis study found no association between adherence to the Mediterranean diet and beta-amyloid deposition in a cohort of healthy Australian women.

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