Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Developmental Cell

• Publication date

  2016-10-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.devcel.2016.08.020PMID 27693507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integrins synergise to induce expression of the MRTF-A–SRF target gene ISG15 for promoting cancer cell invasion

  2016cited by this paper
• Systematic comparison of CRISPR-Cas9 and RNAi screens for essential genes

  2016cited by this paper
• Genetic compensation induced by deleterious mutations but not gene knockdowns

  2015cited by this paper
• DOCK6 Mutations Are Responsible for a Distinct Autosomal‐Recessive Variant of Adams–Oliver Syndrome Associated with Brain and Eye Anomalies

  2015cited by this paper
• DOCK6 Mutations Are Responsible for a Distinct Autosomal‐Recessive Variant of Adams–Oliver Syndrome Associated with Brain and Eye Anomalies

  2015cited by this paper
• ISGylation governs the oncogenic function of Ki-Ras in breast cancer

  2014cited by this paper
• Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis.

  2014cited by this paper
• Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

  2014cited by this paper
• Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells

  2014cited by this paper
• ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

  2012cited by this paper
• Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia

  2011cited by this paper
• Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells.

  2011cited by this paper
• Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome.

  2011cited by this paper
• Interferon-Stimulated Gene 15 and the Protein ISGylation System

  2011cited by this paper
• Emerging role of ISG15 in antiviral immunity.

  2010cited by this paper
• The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

  2010cited by this paper
• Linking actin dynamics and gene transcription to drive cellular motile functions

  2010cited by this paper
• A perinuclear actin cap regulates nuclear shape

  2009cited by this paper
• Adhesion signaling – crosstalk between integrins, Src and Rho

  2009cited by this paper
• Crystal Structure of the GTPase-activating Protein-related Domain from IQGAP1

  2009cited by this paper
• Kif15 cooperates with eg5 to promote bipolar spindle assembly.

  2009cited by this paper
• Rac activation and inactivation control plasticity of tumor cell movement.

  2008cited by this paper
• Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.

  2007cited by this paper
• GEF what? Dock180 and related proteins help Rac to polarize cells in new ways.

  2007cited by this paper
• IQGAP1 in cellular signaling: bridging the GAP.

  2006cited by this paper
• Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

  2005cited by this paper
• Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

  2005cited by this paper
• IQGAP1: a key regulator of adhesion and migration

  2005cited by this paper
• Defining the mammalian CArGome.

  2005cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• Cdc42 and mDia3 regulate microtubule attachment to kinetochores

  2004cited by this paper
• Rho and Rac take center stage.

  2004cited by this paper
• Actin dynamics control SRF activity by regulation of its coactivator MAL.

  2003cited by this paper
• Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

  2003cited by this paper
• Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling.

  2003cited by this paper
• The role of Rho GTPases in disease development.

  2002cited by this paper
• IQGAP1 Is a Component of Cdc42 Signaling to the Cytoskeleton*

  2002cited by this paper
• Localized Rac activation dynamics visualized in living cells.

  2000cited by this paper
• Use and properties of ROCK-specific inhibitor Y-27632.

  2000cited by this paper
• Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior

  1999cited by this paper
• Rac Downregulates Rho Activity

  1999cited by this paper
• Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.

  1999cited by this paper
• IQGAP1, a calmodulin‐binding protein with a rasGAP‐related domain, is a potential effector for cdc42Hs.

  1996cited by this paper

• SDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading

  2025cites this paper
• SDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading

  2025cites this paper
• Familial Exudative Vitreoretinopathy-Like Retinal Findings in Adams-Oliver Syndrome Type 2.

  2025cites this paper
• Protein ISGylation: a posttranslational modification with implications for malignant neoplasms

  2023cites this paper
• Chemogenetic Depletion of Hypophysiotropic GnRH Neurons Does Not Affect Fertility in Mature Female Zebrafish

  2022cites this paper
• Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2

  2022cites this paper
• Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells

  2022cites this paper
• Depletion of ALMS1 affects TGF-β signalling pathway and downstream processes such as cell migration and adhesion capacity

  2022cites this paper
• Attenuated clinical and osteoclastic phenotypes of Paget’s disease of bone linked to the p.Pro392Leu/SQSTM1 mutation by a rare variant in the DOCK6 gene

  2022cites this paper
• ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

  2021cites this paper
• ISG15 and ISGylation: Emergence in the cytoskeleton dynamic and tumor microenvironment

  2021influential citation
• Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis.

  2021cites this paper
• APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

  2021cites this paper
• CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

  2021cites this paper
• MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model

  2021cites this paper
• The interplay between IQGAP1 and small GTPases in cancer metastasis.

  2021cites this paper
• Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function

  2020cites this paper
• The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors

  2020cites this paper
• Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

  2020cites this paper
• Sustained Inflammatory Signalling through Stat1/Stat2/IRF9 Is Associated with Amoeboid Phenotype of Melanoma Cells

  2020cites this paper
• ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

  2020cites this paper
• More than Meets the ISG15: Emerging Roles in the DNA Damage Response and Beyond

  2020cites this paper
• Molecular pathways of Interferon-Stimulated Gene 15: Implications in cancer.

  2020cites this paper
• Mechanism of cell-intrinsic adaptation to Adams-Oliver Syndrome gene DOCK6 disruption highlights ubiquitin-like modifier ISG15 as a regulator of RHO GTPases

  2019influential citation
• Expert Opinion on Orphan Drugs Current opinion in the molecular genetics of Adams-Oliver syndrome

  2019cites this paper
• Current opinion in the molecular genetics of Adams-Oliver syndrome

  2019cites this paper
• ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

  2019cites this paper
• Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds

  2019cites this paper
• Interplay between interferon-stimulated gene 15/ISGylation and interferon gamma signaling in breast cancer cells.

  2019cites this paper
• Non-muscle myosin IIA is post-translationally modified by interferon-stimulated gene 15 in breast cancer cells.

  2019cites this paper
• Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation

  2018cites this paper
• ISG15 in antiviral immunity and beyond

  2018cites this paper
• Protein ISGylation and free ISG15 levels are increased by interferon gamma in breast cancer cells.

  2018cites this paper
• MISP regulates the IQGAP1/Cdc42 complex to collectively orchestrate spindle orientation and mitotic progression

  2018cites this paper
• miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis

  2018cites this paper
• Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression

  2017cites this paper
• Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells

  2017influential citation
• Giantin knockout models reveal the capacity of the 1 Golgi to regulate its biochemistry 2 by controlling glycosyltransferase expression 3

  2017cites this paper
• DOCK6 inactivation highlights ISGylation as RHO-GTPase balancer

  2017influential citation
• ISGylation – a key to lock the cell gates for preventing the spread of threats

  2017cites this paper
• A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

  2017cites this paper
• Many roads to symmetry breaking: molecular mechanisms and theoretical models of yeast cell polarity

  2017cites this paper
• Coping with Loss: Cell Adaptation to Cytoskeleton Disruption.

  2016cites this paper