Synthesis and Pharmacological Evaluation of Analogs of Indole‐Based Cannabimimetic Agents

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Chemical Biology and Drug Design

• Publication date

  2010-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1747-0285.2009.00910.xPMID 19895505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction.

  2009cited by this paper
• Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity.

  2009cited by this paper
• Indoles and related compounds as cannabinoid ligands.

  2008cited by this paper
• Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

  2008cited by this paper
• 2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.

  2007cited by this paper
• Cannabinoids and pain.

  2007cited by this paper
• Cannabinoids and Multiple Sclerosis

  2007cited by this paper
• New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists.

  2007cited by this paper
• 2‐Arylimino‐5,6‐dihydro‐4H‐1,3‐thiazines as a New Class of Cannabinoid Receptor Agonists. Part 1. Discovery of CB2 Receptor Selective Compounds.

  2007cited by this paper
• Recent progress in cannabinoid research.

  2006cited by this paper
• Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

  2006cited by this paper
• WIN55212-2 Docking to the CB1 Cannabinoid Receptor and Multiple Pathways for Conformational Induction

  2006cited by this paper
• The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food

  2005cited by this paper
• CB2 receptor ligands.

  2005cited by this paper
• Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes.

  2005cited by this paper
• Cannabinoid Receptors and Their Relationships with Neuropsychiatric Disorders

  2005cited by this paper
• Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor.

  2005cited by this paper
• Will the new CB1 cannabinoid receptor antagonist SR-147778 have advantages over rimonabant?

  2005cited by this paper
• Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

  2005cited by this paper
• Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia.

  2004cited by this paper
• Behavioral mechanisms underlying inhibition of food-maintained responding by the cannabinoid receptor antagonist/inverse agonist SR141716A.

  2004cited by this paper
• Evaluation of the tail formalin test in mice as a new model to assess local analgesic effects.

  2004cited by this paper
• Cannabinoid CB2 Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains

  2003cited by this paper
• Cannabinoids for gastrointestinal diseases: potential therapeutic applications

  2003cited by this paper
• Cannabinoids and pain

  2003cited by this paper
• Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists.

  2003cited by this paper
• The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats

  2003cited by this paper
• The endocannabinoid nervous system: unique opportunities for therapeutic intervention.

  2001cited by this paper
• Cannabinoids and pain.

  2001cited by this paper
• Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.

  2001cited by this paper
• Cannabinoids in Clinical Practice

  2000cited by this paper
• High-resolution NMR and computer modeling studies of the cannabimimetic aminoalkylindole prototype WIN-55212-2.

  1999cited by this paper
• Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis.

  1998cited by this paper
• Effects of Dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease

  1997cited by this paper
• Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

  1996cited by this paper
• Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics.

  1995cited by this paper
• Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids.

  1995cited by this paper
• The formalin test: scoring properties of the first and second phases of the pain response in rats

  1995cited by this paper
• Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol.

  1992cited by this paper
• Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor.

  1992cited by this paper
• Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.

  1991cited by this paper
• An evaluation of computational strategies for use in the determination of protein structure from distance constraints obtained by nuclear magnetic resonance.

  1991cited by this paper
• Aminoalkylindoles: actions on specific G-protein-linked receptors.

  1991cited by this paper
• Antinociceptive (aminoalkyl)indoles.

  1991cited by this paper
• Pravadoline: profile in isolated tissue preparations.

  1990cited by this paper
• The molecular basis of cannabinoid activity.

  1990cited by this paper
• Molecular mechanics. The MM3 force field for hydrocarbons. 1

  1989cited by this paper
• Determination and characterization of a cannabinoid receptor in rat brain.

  1988cited by this paper
• Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system

  1988cited by this paper
• Determination of three‐dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms Circumventing problems associated with folding

  1988cited by this paper
• Crystallographic R Factor Refinement by Molecular Dynamics

  1987cited by this paper
• The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

  1977cited by this paper

• On the Biomedical Properties of Endocannabinoid Degradation and Reuptake Inhibitors: Pre-clinical and Clinical Evidence

  2021cites this paper
• The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

  2020cites this paper
• Visible-light-induced oxidant and metal-free dehydrogenative cascade trifluoromethylation and oxidation of 1,6-enynes with water

  2017cites this paper
• Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

  2016cites this paper
• Drogas legales emergentes: marihuana sintética, kratom, salvia divinorum, metoxetamina y los derivados de la piperazina

  2015cites this paper
• First X-ray structural characterization of isatin Schiff base derivative. NMR and theoretical conformational studies

  2014cites this paper
• Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines

  2012cites this paper
• REVIEWARTICLE Here Today , Gone Tomorrow ... and Back Again ? A Review of Herbal Marijuana Alternatives ( K 2 , Spice ) , Synthetic Cathinones ( Bath Salts ) , Kratom , Salvia divinorum , Methoxetamine , and Piperazines

  2012cites this paper
• Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls.

  2011cites this paper
• Multicomponent Cascade Reactions: A Novel and Expedient Approach to Functionalized Indoles by an Unprecedented Nucleophilic Addition‐Heterocyclization‐Oxidative Alkoxycarbonylation Sequence

  2010cites this paper