Altered Synapse Stability in the Early Stages of Tauopathy

Summary Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly, whereas presynaptic boutons are stabilized. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically driven neuronal activity in pre-degenerative stages of the disease.

• Publication year

  2017

• Venue

  Cell Reports

• Publication date

  2017-03-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.celrep.2017.03.013PMID 28355559PMCID 5382238
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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