Biphasic effects of halothane on phospholipid and synaptic plasma membranes: a spin label study.

Halothane at 0.16 and 0.32 mM increased, while at 9.3 mM it decreased, the order parameter in palmitoyllauroyllecithin vesicles containing stearic acid spin label I(12,3). A corresponding effect was seen in rat brain synaptic plasma membranes. In dipalmitoyllecithin vesicles the lateral diffusion of stearic acid spin label I(5,10) was inhibited by halothane at 0.32-1.60 mM and promoted by it at 9.3 mM. Halothane in these three membrane systems exerted a biphasic effect, low concentrations ordering and high concentrations disordering the lipid structure of the membranes.

• Publication year

  1975

• Venue

  Molecular Pharmacology

• Publication date

  1975-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0026-895x(25)10704-9PMID 173985
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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