Involvement of central serotonergic pathways in nefopam-induced antinociception.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  European Journal of Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 2442003
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lesions of the ascending serotonergic pathways and antinociceptive effects after systemic administration of p-chloroamphetamine in mice.

  1986cited by this paper
• Evidence of the involvement of dopamine in the analgesic effect of nefopam.

  1986cited by this paper
• Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat.

  1986cited by this paper
• A modified hot-plate test sensitive to mild analgesics.

  1986cited by this paper
• Test-dependent antinociceptive effect of spinal serotonin release induced by intrathecal p-chloroamphetamine in mice.

  1985cited by this paper
• Formalin test in mice, a useful technique for evaluating mild analgesics.

  1985cited by this paper
• Involvement of biogenic amines with the mechanisms of novel analgesics

  1983cited by this paper
• Serotonin receptor antagonists induce hyperalgesia without preventing morphine antinociception.

  1983cited by this paper
• In vitro biochemical effects of nefopam hydrochloride, a new analgesic agent.

  1981cited by this paper
• Spinal and Supraspinal sites for morphine and nefopam analgesia in the mouse.

  1981cited by this paper
• Electrophysiological investigations on the mode of action of nefopam, a novel analgesic agent.

  1981cited by this paper
• Total and free serum tryptophan levels and brain 5‐hydroxytryptamine metabolism in arthritic rats

  1980cited by this paper
• Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

  1980cited by this paper
• Changes in brain and spinal tryptophan and 5-hydroxyindoleacetic acid levels following acute morphine administration in normal and arthritic rats.

  1979cited by this paper
• Analgesic studies with nefopam hydrochloride.

  1977cited by this paper
• Serotonin‐containing neurons: their possible role in pain and analgesia

  1977cited by this paper
• A Comparison of the Analgesic Effect of Intramuscular Nefopam and Morphine in Patients with Postoperative Pain

  1977cited by this paper
• Changes in serotonin (5-HT) concentrations in brain tissue of rats with adjuvant-induced polyarthritis.

  1974cited by this paper
• Increased serotonin turnover in the acutely morphine treated rat.

  1971cited by this paper

• Effect of combined acetaminophen and nefopam on postoperative pain in patients undergoing robot-assisted urological surgery: a retrospective propensity score-matched analysis

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• Nefopam analgesia and its role in multimodal analgesia: A review of preclinical and clinical studies

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• Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test

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• Efficacy and Safety of Neuromodulators in Inflammatory Arthritis: A Cochrane Systematic Review

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• Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice

  2011cites this paper
• ANNALES ACADEMIAE MEDICAE SILESIENSIS

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• Long-Term Pain Vulnerability After Surgery in Rats: Prevention by Nefopam, an Analgesic with Antihyperalgesic Properties

  2009cites this paper
• Nefopam and ketoprofen synergy in rodent models of antinociception.

  2008cites this paper
• Nefopam is more potent than carbamazepine for neuroprotection against veratridine in vitro and has anticonvulsant properties against both electrical and chemical stimulation

  2006influential citation
• Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception.

  2006cites this paper
• Nefopam and Ketamine Comparably Enhance Postoperative Analgesia

  2005cites this paper
• Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels

  2005cites this paper
• Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat.

  2004cites this paper
• Nefopam, a Nonsedative Benzoxazocine Analgesic, Selectively Reduces the Shivering Threshold in Unanesthetized Subjects

  2004cites this paper
• Neuronal Sensitization and Its Behavioral Correlates in a Rat Model of Neuropathy Are Prevented by a Cyclic Analog of Orphenadrine

  2003cites this paper
• Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity

  2002cites this paper
• Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat.

  2002cites this paper
• Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat.

  2001cites this paper
• Salmon calcitonin potentiates the analgesia induced by antidepressants.

  2001cites this paper
• Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine.

  2001cites this paper
• Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans.

  1999cites this paper
• Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.

  1999cites this paper
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  1999cites this paper
• BDNF Produces Analgesia in the Formalin Test and Modifies Neuropeptide Levels in Rat Brain and Spinal Cord Areas Associated With Nociception

  1995cites this paper
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  1994cites this paper
• Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model.

  1993cites this paper
• Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice.

  1993cites this paper
• Solid-state stereochemistry and activity of 3-methylnefopam diastereomers: manipulation of eight-membered ring conformations in analogues of the non-narcotic analgesic drug.

  1993cites this paper
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  1992cites this paper
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  1992cites this paper
• [Mode of action of non-narcotic analgesics].

  1992cites this paper
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  1991cites this paper
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  1991cites this paper
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  1990cites this paper
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  1990cites this paper
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  1989cites this paper
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  1989cites this paper