Site of action of the local anesthetic tetracaine in a phosphatidylcholine bilayer with incorporated cardiolipin.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Biophysical Journal

• Publication date

  1995-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-3495(95)79920-9PMID 8527661PMCID PMC1236272
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

  1994cited by this paper
• Significant stabilization of the phosphatidylcholine bilayer structure by incorporation of small amounts of cardiolipin.

  1994cited by this paper
• The local anesthetic tetracaine destabilizes membrane structure by interaction with polar headgroups of phospholipids.

  1992cited by this paper
• Alcohols dehydrate lipid membranes: an infrared study on hydrogen bonding.

  1992cited by this paper
• Interfacial ionization and partitioning of membrane-bound local anesthetics.

  1992cited by this paper
• On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes.

  1992cited by this paper
• Is bupivacaine a decoupler, a protonophore or a proton‐leak‐inducer?

  1992cited by this paper
• The structure of anhydrous and hydrated dimyristoylphosphatidyl glycerol: a pressure tuning infrared spectroscopic study.

  1992cited by this paper
• Cardiolipins and biomembrane function.

  1992cited by this paper
• Intramolecular hydrogen bonding in cardiolipin.

  1991cited by this paper
• Molecular Details of Anesthetic‐Lipid Interaction a

  1991cited by this paper
• Slipping pumps or proton leaks in oxidative phosphorylation

  1990cited by this paper
• Effects of the local anesthetic bupivacaine on oxidative phosphorylation in mitochondria. Change from decoupling to uncoupling by formation of a leakage type ion pathway specific for H+ in cooperation with hydrophobic anions.

  1990cited by this paper
• Molecular structure of tetanus neurotoxin as revealed by Fourier transform infrared and circular dichroic spectroscopy.

  1990cited by this paper
• Electric charge effects on phospholipid headgroups. Phosphatidylcholine in mixtures with cationic and anionic amphiphiles.

  1989cited by this paper
• High-pressure infrared spectroscopic evidence of water binding sites in 1,2-diacyl phospholipids

  1988cited by this paper
• Effects of the local anesthetic tetracaine on the structural and dynamic properties of lipids in model membranes: a high-pressure Fourier transform infrared study.

  1988cited by this paper
• Fourier transform infrared-attenuated total reflection spectroscopy of hydration of dimyristoylphosphatidylcholine multibilayers.

  1988cited by this paper
• Fourier transform infrared spectroscopy of 13C = O-labeled phospholipids hydrogen bonding to carbonyl groups.

  1988cited by this paper
• Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group.

  1988cited by this paper
• Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function.

  1987cited by this paper
• Infrared studies of fully hydrated saturated phosphatidylserine bilayers. Effect of Li+ and Ca2+.

  1987cited by this paper
• A 2H-NMR study on the interactions of the local anesthetic tetracaine with membranes containing phosphatidylserine.

  1986cited by this paper
• Local anesthetic-phospholipid interactions. The pH dependence of the binding of dibucaine to dimyristoylphosphatidylcholine vesicles.

  1985cited by this paper
• Adsorption of local anesthetics on phospholipid membranes.

  1984cited by this paper
• Effect of lipid membranes on the apparent pK of the local anesthetic tetracaine. Spin label and titration studies.

  1984cited by this paper
• Polymorphic phase behaviour of phospholipid membranes studied by infrared spectroscopy.

  1984cited by this paper
• Dissociation constants of local anesthetics and their temperature dependence.

  1983cited by this paper
• Anionic lipid headgroups as a proton-conducting pathway along the surface of membranes: a hypothesis.

  1983cited by this paper
• The effect of neutral and charged micelles on the acid-base dissociation of the local anesthetic tetracaine.

  1983cited by this paper
• Structure and thermotropic behavior of phosphatidylserine bilayer membranes.

  1982cited by this paper
• Molecular details of anesthetic--lipid interaction as seen by deuterium and phosphorus-31 nuclear magnetic resonance.

  1981cited by this paper
• A Fourier transform infrared spectroscopic study of the molecular interaction of cholesterol with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine.

  1980cited by this paper
• Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

  1978cited by this paper
• Fourier transform infrared spectroscopy

  1978cited by this paper
• Studies on membrane fusion. III. The role of calcium-induced phase changes.

  1977cited by this paper
• Hydration sites of egg phosphatidylcholine determined by means of modulated excitation infrared spectroscopy.

  1976cited by this paper
• The influence of anesthetics and cholesterol on the degree of molecular organization and mobility of ox brain white matter. Lipids in multibilayer membranes: a spin probe study using spectral simulation by the stochastic method.

  1976cited by this paper
• Phospholipid model membranes. 3. Antagonistic effects of Ca2+ and local anesthetics on the permeability of phosphatidylserine vesicles.

  1970cited by this paper
• Reaction of Local Anesthetics with Phospholipids A possible chemical basis for anesthesia

  1964cited by this paper
• Reaction of Local Anesthetics with Phospholipids

  1964cited by this paper
• The identification and determination of some official local anesthetics as tetraphenylborates.

  1959cited by this paper
• [Preparation of cardiolipid. II. Quick method].

  1958cited by this paper

• Anticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures?

  2020cites this paper
• Introduction of Positive Charges into Zwitterionic Phospholipid Monolayers Disrupts Water Structure Whereas Negative Charges Enhances It.

  2018cites this paper
• On the structure of prilocaine in aqueous and amphiphilic solutions.

  2017cites this paper
• An increase in model lipid membrane fluidity as a result of local anesthetic action

  2016cites this paper
• Differential interactions of two local anesthetics with phospholipid membrane and nonerythroid spectrin: Localization in presence of cholesterol and ganglioside, GM1.

  2015cites this paper
• Effect of tetracaine on DMPC and DMPC+cholesterol biomembrane models: liposomes and monolayers.

  2014cites this paper
• Anesthetic Diffusion Through Lipid Membranes Depends on the Protonation Rate

  2014cites this paper
• Sensing small molecule interactions with lipid membranes by local pH modulation.

  2013cites this paper
• New procedure to synthesize silver nanoparticles and their interaction with local anesthetics

  2013cites this paper
• Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles.

  2012cites this paper
• Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes.

  2011cites this paper
• Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes

  2010cites this paper
• The effect of dimiristoylphosphatidylethanol on the rotational mobility of n-(9-Anthroyloxy) stearic acid in neuronal and model membranes

  2010influential citation
• Molecular dynamics study of biomembrane/local anesthetics interactions

  2009cites this paper
• Biphasic behavior of bupivacaine and cardiolipin-containing biomimetic membrane interaction

  2008cites this paper
• Water solvent and local anesthetics: a computational study

  2007cites this paper
• Amphiphilic effects of dibucaine HCl on rotational mobility of n-(9-anthroyloxy)stearic acid in neuronal and model membranes.

  2007cites this paper
• Bupivacaine, but not lidocaine, disrupts cardiolipin-containing small biomimetic unilamellar liposomes.

  2007cites this paper
• Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization.

  2007cites this paper
• Theoretical studies on water–tetracaine interaction

  2006cites this paper
• Local anesthetics facilitate ion transport across lipid planar bilayer membranes under an electric field: dependence on type of lipid bilayer.

  2005cites this paper
• Evidence for heterodimers of 2,4,5-trichlorophenol on planar lipid layers. A FTIR-ATR investigation.

  2004cites this paper
• Amphiphilic effects of local anesthetics on rotational mobility in neuronal and model membranes.

  2002cites this paper
• Mitochondrial creatine kinase binding to phospholipids decreases fluidity of membranes and promotes new lipid-induced beta structures as monitored by red edge excitation shift, laurdan fluorescence, and FTIR.

  2001cites this paper
• Molecular characteristics of astaxanthin and beta-carotene in the phospholipid monolayer and their distributions in the phospholipid bilayer.

  2001cites this paper
• Interaction of local anesthetics with phospholipids in Langmuir monolayers.

  2000cites this paper
• High‐pressure 1H NMR on model biomembranes: a study of the local anaesthetic tetracaine incorporated into POPC lipid bilayers

  2000cites this paper
• Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects.

  2000cites this paper
• Do local anesthetics have an influence on the percutaneous penetration of a model corticosteroid? An in vivo study using the vasoconstrictor assay.

  1999cites this paper
• The electrostriction, surface potential and capacitance relaxation of bilayer lipid membranes induced by tetracaine

  1998cites this paper
• Electropermeabilization and electrofusion of human cells modified by anaesthetic agents

  1998cites this paper
• Effect of local anesthetics on accessibility and thermal stability of the rat ovarian LH/hCG receptor.

  1998cites this paper
• Interactions at the lipid–water interface

  1998cites this paper
• Inner sarcolemmal leaflet Ca(2+) binding: its role in cardiac Na/Ca exchange.

  1996cites this paper
• Light-induced reversible local fusions of thylakoid membranes in the presence of dibucaine or tetracaine.

  1996cites this paper
• Molecular and physicochemical aspects of local anesthetic-membrane interaction.

  1996cites this paper
• A comparative electron spin resonance investigation on the effects of barbital and tetracaine on DPPC multilayers

  1995cites this paper