Control of bract formation in Drosophila: poxn, kek1, and the EGF‐R pathway

Summary: In Drosophila, the sensory organs are formed by cells that derive from a precursor cell through a fixed lineage. One exception to this rule is the bract cell that accompanies some of the adult bristles. The bract cell is derived from the surrounding epidermis and is induced by the bristle cells. On the adult tibia, bracts are associated with all mechanosensory bristles, but not with chemosensory bristles. The differences between chemosensory and mechanosensory lineages are controlled by the selector gene pox‐neuro (poxn). Here we show that poxn is also involved in suppressing bract formation near the chemosensory bristles. We have identified the gene kek1, described as an inhibitor of the EGF‐R signaling pathway, in a screen for poxn downstream genes. We show that kek1 can suppress bract formation and can interfere with other steps of sensory development, including SMC determination and shaft differentiation. genesis 39:246–255, 2004. © 2004 Wiley‐Liss, Inc.

• Publication year

  2004

• Venue

  Genesis

• Publication date

  2004-07-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gene.20052PMID 15286997
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• kek1 can suppress bract formation and interfere with SMC determination and shaft differentiation.

  Confidence 0.92

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• kek1 was identified in a screen for poxn downstream genes.

  Confidence 0.88

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• poxn suppresses bract formation near chemosensory bristles.

  Confidence 0.93

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review

• bract formation

  developmental process

  The developmental process that produces the bract cell associated with some adult bristles.

  Aliases: bract cell formation

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• chemosensory bristles

  cell type

  Adult bristles associated with chemical sensing in Drosophila, contrasted here with mechanosensory bristles.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• kek1

  gene

  A gene described as an inhibitor of the EGF-R signaling pathway and examined as a poxn downstream candidate.

  Aliases: kek-1

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• poxn

  gene

  The selector gene pox-neuro involved in distinguishing sensory bristle lineages in Drosophila.

  Aliases: pox-neuro

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• shaft differentiation

  developmental process

  The developmental process that produces the shaft cell fate in the sensory organ lineage.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review
• smc determination

  developmental process

  The developmental step in which a sensory mother cell is specified during sensory organ formation.

  Aliases: sensory mother cell determination, SMC specification

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewq (76h6bfydm6) reviewmexicorea (qjvnbu8xg3) review

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