MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma

MicroRNAs (miRNAs) regulate gene expression by targeted repression of transcription and translation, and are involved in carcinogenesis. In this study, we demonstrated that the expression of miR‐454 was up‐regulated in uveal melanoma tissues compared to normal tissues. Ectopic expression of miR‐454 resulted in significant promotion of cell proliferation, colony formation, invasion and induction of cell cycle in uveal melanoma cells. Furthermore, we identified PTEN as a direct target of miR‐454. Our data revealed that ectopic expression of PTEN restored the effects of miR‐454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR‐454 in development of uveal melanoma.

• Publication year

  2015

• Venue

  FEBS Letters

• Publication date

  2015-09-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2015.08.007PMID 26296312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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