SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular Endocrinology

• Publication date

  2013-01-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/me.2012-1347PMID 23340254PMCID PMC3589668
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epigenetics in breast cancer.

  2013cited by this paper
• On hormone action in the mammary gland.

  2012cited by this paper
• The Orphan Nuclear Receptor LRH-1 and ERα Activate GREB1 Expression to Induce Breast Cancer Cell Proliferation

  2012cited by this paper
• Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole.

  2011cited by this paper
• Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma.

  2011cited by this paper
• New and translational perspectives of oestrogen deprivation in breast cancer.

  2011cited by this paper
• Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

  2011cited by this paper
• SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

  2011cited by this paper
• An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

  2010cited by this paper
• SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

  2010influential reference
• Epigenetic modifications and human disease

  2010influential reference
• American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer.

  2010cited by this paper
• The epigenetics of breast cancer

  2010cited by this paper
• The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression

  2010influential reference
• The Tumor Stromal Microenvironment as Modulator of Malignant Behavior

  2010cited by this paper
• Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms

  2010cited by this paper
• Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling.

  2010cited by this paper
• Hormone action in the mammary gland.

  2010cited by this paper
• American society of clinical oncology clinical practice guideline update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer.

  2010cited by this paper
• SIRT1 Histone Deacetylase Expression Is Associated with Microsatellite Instability and CpG Island Methylator Phenotype in Colorectal Cancer

  2009cited by this paper
• Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells.

  2009cited by this paper
• Regulation of breast cancer-associated aromatase promoters.

  2009cited by this paper
• History of aromatase: saga of an important biological mediator and therapeutic target.

  2009cited by this paper
• COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES

  2009cited by this paper
• Regulation of Aromatase Expression in Breast Cancer Tissue

  2009cited by this paper
• The critical role of the class III histone deacetylase SIRT1 in cancer.

  2009cited by this paper
• Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.

  2009cited by this paper
• A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer.

  2009cited by this paper
• Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma

  2009cited by this paper
• Deacetylation of cortactin by SIRT1 promotes cell migration

  2009cited by this paper
• SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma

  2008cited by this paper
• Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

  2008cited by this paper
• SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice

  2007cited by this paper
• Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells.

  2007cited by this paper
• Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires β-catenin

  2006cited by this paper
• Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

  2006influential reference
• Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

  2006influential reference
• Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

  2005cited by this paper
• Regulation of Aromatase Expression in Estrogen-Responsive Breast and Uterine Disease: From Bench to Treatment

  2005influential reference
• Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.

  2005cited by this paper
• Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

  2005cited by this paper
• Estrogen-Related Receptor α in Human Breast Carcinoma as a Potent Prognostic Factor

  2004cited by this paper
• Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

  2004cited by this paper
• The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.

  2003cited by this paper
• The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

  2003cited by this paper
• Aromatase inhibitors for breast cancer: lessons from the laboratory

  2003cited by this paper
• Estrogen-related Receptor α and Estrogen-related Receptor γ Associate with Unfavorable and Favorable Biomarkers, Respectively, in Human Breast Cancer

  2002cited by this paper
• Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer.

  2002cited by this paper
• Stromal Effects on Mammary Gland Development and Breast Cancer

  2002cited by this paper
• Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes*

  2002cited by this paper
• Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).

  2001cited by this paper
• Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group.

  2001cited by this paper
• A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project.

  2001cited by this paper
• Anastrozole is superior to tamoxifen as first‐line therapy in hormone receptor positive advanced breast carcinoma

  2001cited by this paper
• Anastrozole Is Superior to Tamoxifen as First-Line Therapy in Hormone Receptor Positive Advanced Breast Carcinoma Results of Two Randomized Trials Designed for Combined Analysis

  2001cited by this paper
• Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group.

  2000cited by this paper
• Modulation of Aromatase Expression in the Breast Tissue by ERRα-1 Orphan Receptor

  1998cited by this paper
• Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.

  1998cited by this paper
• Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.

  1996cited by this paper
• Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis.

  1994cited by this paper
• [Estrogen synthetase (P-450 . aromatase) as a regulatory factor concerning sexual differentiation of brain and sexual behavior--physiological functions and regulation of gene expression of aromatase].

  1993cited by this paper
• Progestin-dependent effect of forskolin on human endometrial aromatase activity.

  1987cited by this paper
• Reproductive Biology and Endocrinology Open Access a Novel Promoter Controls Cyp19a1 Gene Expression in Mouse Adipose Tissue

  year unknowncited by this paper

• Decreased Sirtuin1 Protein and Aromatase Activity Index in Follicular Fluid is Correlated with Increased Germinal Vesicle Count in Polycystic Ovary Syndrome

  2025cites this paper
• Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation

  2025cites this paper
• Evaluation of the potential of serum cortisol level and expression of StAR gene as biomarkers to establish the nature of sexual act.

  2025cites this paper
• Multifaceted landscape of the StAR protein in steroid biosynthesis: from development to degeneration.

  2025cites this paper
• SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β

  2024cites this paper
• The Estrogen–Autophagy Axis: Insights into Cytoprotection and Therapeutic Potential in Cancer and Infection

  2024cites this paper
• Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies

  2023cites this paper
• Sirtuin 1 Expression in Canine Mammary Tumors: A Pilot Study

  2023cites this paper
• Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer

  2023cites this paper
• Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer

  2022cites this paper
• Flavonoids as Sirtuin Modulators.

  2022cites this paper
• Evaluation of the Relationship Between Aromatase/Sirtuin1 Interaction and miRNA Expression in Human Neuroblastoma Cells.

  2022cites this paper
• The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer

  2022cites this paper
• Virtual Screening in the Identification of Sirtuins’ Activity Modulators

  2022cites this paper
• Additive pharmacological interaction between sirtuin inhibitor cambinol and paclitaxel in MCF7 luminal and MDA-MB-231 triple-negative breast cancer cells

  2022cites this paper
• Hormonal and Genetic Regulatory Events in Breast Cancer and Its Therapeutics: Importance of the Steroidogenic Acute Regulatory Protein

  2022cites this paper
• Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer

  2021cites this paper
• Photoperiodic modulation of ovarian metabolic, survival, proliferation and gap junction markers in adult golden hamster, Mesocricetus auratus.

  2021cites this paper
• Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature

  2021cites this paper
• Mechanisms of Endocrine Therapy Resistance in Breast Cancer.

  2021cites this paper
• Regulation of aromatase expression: Potential therapeutic insight into breast cancer treatment.

  2021cites this paper
• Targeting SIRT1 to inhibit the proliferation of multiple myeloma cells

  2021cites this paper
• SIRT1 and gynecological malignancies

  2021cites this paper
• Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators

  2021cites this paper
• Sirtuins—The New Important Players in Women’s Gynecological Health

  2021cites this paper
• Regulation of aromatase in cancer

  2021cites this paper
• The Versatility of Sirtuin-1 in Endocrinology and Immunology

  2020cites this paper
• Emerging Role of Sirtuins in Breast Cancer Metastasis and Multidrug resistance: Implication for Novel Therapeutic Strategies Targeting Sirtuins.

  2020cites this paper
• Cambinol/Neutral Sphingomyelinase Inhibitors

  2020cites this paper
• Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications

  2020cites this paper
• Natural Products as Modulators of Sirtuins

  2020cites this paper
• Overexpression of the steroidogenic acute regulatory protein in breast cancer: Regulation by histone deacetylase inhibition.

  2019cites this paper
• The effect of adipocyte-macrophage crosstalk in obesity-related breast cancer.

  2019cites this paper
• SIRT1: a potential tumour biomarker and therapeutic target

  2019cites this paper
• Noscapine Inhibiting the Growth and Angiogenesis of Human Eutopic Endometrium of Endometriosis Patients through Expression of Apoptotic Genes and Nitric Oxide Reduction in Three-Dimensional Culture Model

  2019cites this paper
• SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells

  2018cites this paper
• Aromatase Acetylation Patterns and Altered Activity in Response to Sirtuin Inhibition

  2018cites this paper
• SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression

  2018cites this paper
• Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection

  2018cites this paper
• DVL1 and DVL3 differentially localize to CYP19A1 promoters and regulate aromatase mRNA in breast cancer cells

  2018cites this paper
• DVL regulation of tissue-specific aromatase transcripts in breast cancer

  2018cites this paper
• Naturalne i syntetyczne modulatory aktywności sirtuin

  2017cites this paper
• Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers.

  2017cites this paper
• Effects of BMAL1–SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS

  2016cites this paper
• Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies.

  2016cites this paper
• Molecular and Cellular Changes During Cancer Progression Resulting From Genetic and Epigenetic Alterations.

  2016cites this paper
• Effect of 1.2-epoxy-3[3-3[3.4-dimetoxyi- phenil]-4h-1-benzopiran-4-on] Propane (epi) on Sirtuin-1 and Nuclear Factor-kB Expression of DMBA induced Mammary Tumors in sprague dawley rats

  2016cites this paper
• Phosphorylation Processes Controlling Aromatase Activity in Br east Cancer: An Update.

  2016cites this paper
• FXR activation induces mitochondrial mediated apoptosis in breast cancer and synergizes with tamoxifen

  2016cites this paper
• High-throughput screening of Sirtuin family of genes in breast cancer.

  2016cites this paper
• Role of the steroidogenic acute regulatory protein in health and disease

  2015cites this paper
• Transcriptomic characterization of fibrolamellar hepatocellular carcinoma

  2015cites this paper
• The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancer

  2015cites this paper
• Chromatin and Epigenetic Determinants of Resistance to Aromatase Inhibitors

  2015cites this paper
• Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients

  2015cites this paper
• Transcriptional control of local estrogen formation by aromatase in the breast.

  2015cites this paper
• Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

  2015cites this paper
• A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1

  2015cites this paper
• Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target

  2015cites this paper
• Cancer Biology and Signal Transduction Inhibition of SIRT 1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo

  2014cites this paper
• The SIRT 3 Expression Profile is Associated with Pathological and Clinical Outcomes in Human Breast Cancer Patients

  2014cites this paper
• Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance

  2014cites this paper
• Sirtuin inhibitors as anticancer agents.

  2014cites this paper
• Inhibition of SIRT1 Signaling Sensitizes the Antitumor Activity of Silybin against Human Lung Adenocarcinoma Cells In Vitro and In Vivo

  2014cites this paper
• Frizzled 7 Expression Is Positively Regulated by SIRT1 and β-Catenin in Breast Cancer Cells

  2014cites this paper
• The emerging and diverse roles of sirtuins in cancer: a clinical perspective

  2013cites this paper
• SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.

  2013cites this paper
• The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation, and cell migration

  2013cites this paper
• The emerging and diverse roles of sirtuins in cancer: a clinical perspective

  2013cites this paper
• Elevated microRNA‐34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT

  2013cites this paper