Role of Kupffer cells in the induction of tolerance of orthotopic liver transplantation in rats

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Liver transplantation

• Publication date

  2008-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/lt.21450PMID 18508376
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Death Receptor Ligands in Shaping Tumor Microenvironment

  2007cited by this paper
• Cytokine production in lipopolysaccharide-exposed rat lung pericytes.

  2007cited by this paper
• The effects of FasL on inflammation and tumor survival are dependent on its expression levels

  2007cited by this paper
• G‐CSF‐mediated inhibition of JNK is a key mechanism for Lactobacillus rhamnosus‐induced suppression of TNF production in macrophages

  2006cited by this paper
• The protective effect of alpha-tocopherol and GdCl3 against hepatic ischemia/reperfusion injury.

  2006cited by this paper
• Evaluation of microperfusion disturbances in the transplanted liver after Kupffer cell destruction using GdCl3: an experimental porcine study.

  2006cited by this paper
• Role of NF-kappaB as effector of IPC in donor livers before liver transplantation in rats.

  2006cited by this paper
• The role of p65 NF-kB/RelA in pancreatitis-induced kupffer cell apoptosis

  2006cited by this paper
• Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.

  2006cited by this paper
• A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine

  2006cited by this paper
• The potent role of graft-derived NKR-P1[+]TCRαβ[+]T (NKT) cells in the spontaneous acceptance of rat liver allografts

  2006cited by this paper
• Nuclear Factor-κB Mediates Kupffer Cell Apoptosis Through Transcriptional Activation of Fas/FasL1,2

  2006cited by this paper
• Role of NF-κB as Effector of IPC in Donor Livers Before Liver Transplantation in Rats

  2006cited by this paper
• Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

  2006cited by this paper
• Exogenous expression of Fas-ligand or CrmA prolongs the survival in rat liver transplantation.

  2006cited by this paper
• TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.

  2006cited by this paper
• Liver Sinusoidal Endothelial Cells Tolerize T Cells across MHC Barriers in Mice 1

  2005cited by this paper
• The Protective Effect of α-Tocopherol and GdCl3 Against Hepatic Ischemia/Reperfusion Injury

  2005cited by this paper
• Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis

  2005cited by this paper
• Expression of Fas Ligand by Hepatic Macrophages in Patients with Fulminant Hepatic Failure

  2005cited by this paper
• Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells

  2005cited by this paper
• The roles of kupffer cells in hepatic dysfunction induced by ischemia/reperfusion in rats

  2005cited by this paper
• A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine

  2005cited by this paper
• Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells.

  2005cited by this paper
• Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers

  2005cited by this paper
• The Potent Role of Graft-Derived NKR-P1+TCRαβ+ T (NKT) Cells in the Spontaneous Acceptance of Rat Liver Allografts

  2005cited by this paper
• The immune status of Kupffer cells profoundly influences their responses to infectious Plasmodium berghei sporozoites

  2005cited by this paper
• Ischemic preconditioning and intermittent clamping improve murine hepatic microcirculation and Kupffer cell function after ischemic injury

  2004cited by this paper
• Passive and Active Mechanisms Trap Activated CD8+ T Cells in the Liver1

  2004cited by this paper
• Donor pretreatment with gadolinium chloride improves early graft function and survival after porcine liver transplantation

  2003cited by this paper
• Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival

  2003cited by this paper
• Expression of CD80 on Kupffer cells is enhanced in cadaveric liver transplants

  2003cited by this paper
• Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia/reperfusion injury.

  2003cited by this paper
• Liver death and regeneration in paracetamol toxicity

  2003cited by this paper
• Hepatic allograft‐derived Kupffer cells regulate T cell response in rats

  2003cited by this paper
• Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.

  2002cited by this paper
• Immunological tolerance: the liver effect

  2002cited by this paper
• Molecular Pathways of Regeneration and Repair after Liver Transplantation

  2002cited by this paper
• Mechanism of superoxide anion production by hepatic sinusoidal endothelial cells and Kupffer cells during short-term ethanol perfusion in the rat.

  2002cited by this paper
• Liver-infiltrating T lymphocytes cause hepatocyte damage by releasing humoral factors via LFA-1/ICAM-1 interaction in immunological liver injury

  2002cited by this paper
• Inhibition of Kupffer cell activity induces hepatic triglyceride synthesis in fasted rats, independent of lipopolysaccharide challenge.

  2002cited by this paper
• Crucial Fas–Fas ligand interaction in spontaneous acceptance of hepatic allografts in mice

  2002cited by this paper
• Lymphocyte apoptosis and cell replacement in human liver allografts

  2002cited by this paper
• NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor.

  2002cited by this paper
• Spontaneous tolerance: experience with the rat liver transplant model.

  2002cited by this paper
• Kupffer cells play an important role in the cytokine production and activation of nuclear factors of liver grafts from non‐heart‐beating donors

  2002cited by this paper
• Intestinal damage mediated by Kupffer cells in rats with endotoxemia.

  2002cited by this paper
• NF-κB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor

  2002cited by this paper
• Expression of apoptosis and apoptosis-related peptides in various stages of rejection in the human transplanted liver.

  2001influential reference
• Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells

  2001cited by this paper
• Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells, a potential pathway of antiliver metastases.

  2001cited by this paper
• Donor Dendritic Cells and Recipient Kupffer Cells in the Induction of Donor-Specific Immune Hyporesponsiveness

  2001cited by this paper
• Role of Fas/Fasl in Kupffer cell-dependent deletion of alloantigen activated T cells following liver transplantation.

  2001cited by this paper
• Elimination of Kupffer cells suppresses activation of nuclear factor kappa B and production of cytokines and eicosanoids in non-heart-beating donors.

  2001cited by this paper
• MICROCIRCULATORY FAILURE AFTER RAT LIVER TRANSPLANTATION IS RELATED TO KUPFFER CELL-DERIVED OXIDANT STRESS BUT NOT INVOLVED IN EARLY GRAFT DYSFUNCTION1

  2001cited by this paper
• Prolongation of Cardiac Allograft Survival by Selective Injection of Donor Liver Leukocytes in Non-Immunosuppressed Rats

  2000influential reference
• The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses

  2000influential reference
• The liver as a site of T‐cell apoptosis: graveyard, or killing field?

  2000cited by this paper
• The protective role of Kupffer cells in humoral injury of xenoperfused rat livers.

  2000cited by this paper
• Evidence that apoptosis of activated T cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations which break tolerance.

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• Transplantation of cells and tissues expressing Fas ligand.

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells.

  1999cited by this paper
• Protection of sinusoidal endothelial cells against storage/reperfusion injury by prostaglandin E2 derived from Kupffer cells.

  1999cited by this paper
• Interleukin‐10 expression is autoregulated at the transcriptional level in human and murine kupffer cells

  1998influential reference
• Kinetics of intragraft cytokine expression, cellular infiltration, and cell death in rejection of renal allografts compared with acceptance of liver allografts in a rat model: early activation and apoptosis is associated with liver graft acceptance.

  1998cited by this paper
• Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice

  1998cited by this paper
• Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells.

  1998cited by this paper
• Prolongation of discordant heart xenograft survival after liver hemoperfusion: role of nonparenchymal liver cells.

  1997cited by this paper
• Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators.

  1997cited by this paper
• Bile ducts and portal and central veins are major producers of tumor necrosis factor alpha in regenerating rat liver.

  1997cited by this paper
• Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction.

  1997cited by this paper
• Role of Kupffer cells in the induction of tolerance after liver transplantation.

  1996cited by this paper
• In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade.

  1996cited by this paper
• Role of nonparenchymal liver cells in guinea pig to rat hepatic xenotransplantation.

  1993cited by this paper

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  2025cites this paper
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  2025cites this paper
• TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection

  2025cites this paper
• Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

  2025cites this paper
• ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation

  2025cites this paper
• Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity

  2024cites this paper
• TIM proteins and microRNAs: distinct impact and promising interactions on transplantation immunity

  2024cites this paper
• Comparative characterization of Kupffer cells in the livers of SHR and Wistar rats

  2024cites this paper
• The liver as a central "hub" of the immune system: pathophysiological implications.

  2024cites this paper
• Liver-Targeting Nanoplatforms for the Induction of Immune Tolerance

  2023cites this paper
• Extracellular vesicles from bone marrow mesenchymal stem cells alleviate acute rejection injury after liver transplantation by carrying miR‐22‐3p and inducing M2 polarization of Kupffer cells

  2023cites this paper
• Unraveling the Complexities of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma

  2023cites this paper
• The multifaceted role of macrophages during acute liver injury

  2023cites this paper
• Role of Kupffer cells in tolerance induction after liver transplantation

  2023cites this paper
• miR-27a-5p inhibits acute rejection of liver transplantation in rats by inducing M2 polarization of Kupffer cells through the PI3K/Akt pathway.

  2023cites this paper
• The Influence of the Microbiome on Metastatic Colorectal Cancer

  2023cites this paper
• Immune microenvironment and therapeutic progress of recurrent hepatocellular carcinoma after liver transplantation

  2022cites this paper
• Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment

  2021cites this paper
• XBP1s repression regulates Kupffer cell polarization leading to immune suppressive effects protecting liver allograft in rats.

  2021cites this paper
• SCARF1 promotes M2 polarization of Kupffer cells via calcium‐dependent PI3K‐AKT‐STAT3 signalling to improve liver transplantation

  2021cites this paper
• Navigating Immune Cell Immunometabolism after Liver Transplantation.

  2021cites this paper
• Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver

  2020cites this paper
• The Role of Diverse Liver Cells in Liver Transplantation Tolerance

  2020cites this paper
• Adoptive transfer of polarized M2c macrophages ameliorates acute rejection in rat liver transplantation.

  2020cites this paper
• The Impact of Malaria Parasites on Dendritic Cell–T Cell Interaction

  2020cites this paper
• Kupffer Cell-Derived TNF-α Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress

  2020cites this paper
• [Endoplasmic reticulum stress enhances tumor necrosis factor-α expression in rat Kupffer cells to trigger hepatic stellate apoptosis cell through TNFR/caspase-8 pathway].

  2020cites this paper
• Therapeutics administered during ex vivo liver machine perfusion: An overview.

  2020cites this paper
• Lack of Annexin A6 exacerbates liver dysfunction and reduces lifespan of NPC1-deficient mice.

  2020cites this paper
• [Effects of Panax notoginseng saponins on liver graft rejection in rats and the mechanisms].

  2019cites this paper
• Research Status of Mesenchymal Stem Cells in Liver Transplantation

  2019cites this paper
• DNAX Activating Protein of 12 kDa/Triggering Receptor Expressed on Myeloid Cells 2 Expression by Mouse and Human Liver Dendritic Cells: Functional Implications and Regulation of Liver Ischemia–Reperfusion Injury

  2019cites this paper
• TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

  2019cites this paper
• TIM-4 blockade of KCs combined with exogenous TGF-β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts

  2018influential citation
• Preparation of Zoledronate liposome and its impact on apoptosis of Kupffer cells in rat liver.

  2018cites this paper
• Innate Immune Cells in Immune Tolerance After Liver Transplantation

  2018cites this paper
• Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver Transplantation

  2018cites this paper
• The role of Kupffer cells in hepatic diseases

  2017cites this paper
• Immunotolerance in Liver Transplantation

  2017cites this paper
• MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice

  2017cites this paper
• Kupffer cells in immune activation and tolerance toward HBV/HCV infection.

  2017cites this paper
• Liver immunology: How to reconcile tolerance with autoimmunity.

  2017cites this paper
• Transcriptional co-regulator RIP140: An important mediator of the inflammatory response and its associated diseases (Review).

  2017cites this paper
• Role of programmed death ligand 1 and Kupffer cell in immune regulation after orthotopic liver transplantation in rats

  2017cites this paper
• IRAK-4-shRNA Prevents Ischemia/Reperfusion Injury Via Different Perfusion Periods Through the Portal Vein After Liver Transplantation in Rat.

  2016cites this paper
• The CD8 T-cell response during tolerance induction in liver transplantation

  2016cites this paper
• Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy.

  2016cites this paper
• Presentation of hepatocellular antigens

  2016cites this paper
• Augmenter of liver regeneration attenuates acute rejection after rat liver transplantation.

  2016cites this paper
• Mesenchymal stromal cell-dependent reprogramming of Kupffer cells is mediated by TNF-α and PGE2 and is crucial for liver transplant tolerance

  2015cites this paper
• Pretransplant replacement of donor liver grafts with recipient Kupffer cells attenuates liver graft rejection in rats

  2015cites this paper
• Mesenchymal stromal cell-dependent reprogramming of Kupffer cells is mediated by TNF-α and PGE2 and is crucial for liver transplant tolerance

  2015cites this paper
• Tolerogenic Mechanisms in Liver Transplantation

  2015cites this paper
• Withdrawal of immunosuppression in liver transplantation and the mechanism of tolerance.

  2015cites this paper
• Cytidine deamination and cccDNA degradation: A new approach for curing HBV?

  2014cites this paper
• Gadolinium chloride suppresses acute rejection and induces tolerance following rat liver transplantation by inhibiting Kupffer-cell activation

  2014cites this paper
• Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development

  2014cites this paper
• Knockdown of MicroRNA-155 in Kupffer Cells Results in Immunosuppressive Effects and Prolongs Survival of Mouse Liver Allografts

  2014cites this paper
• DAP12 Deficiency in Liver Allografts Results in Enhanced Donor DC Migration, Augmented Effector T Cell Responses and Abrogation of Transplant Tolerance

  2014cites this paper
• Immune tolerance in liver disease

  2014cites this paper
• Clinical Allograft Rejection Syndromes in Liver Transplantation

  2014cites this paper
• Immunosuppression: trends and tolerance?

  2014cites this paper
• Glycogen synthase kinase 3 inhibitor attenuates endotoxin-induced liver injury.

  2013cites this paper
• Taurine Attenuates Liver Injury by Downregulating Phosphorylated p38 MAPK of Kupffer Cells in Rats with Severe Acute Pancreatitis

  2012cites this paper
• Apoptosis Pathways in Ovarian Cancer

  2012cites this paper
• Protective role of Shenfu on ischemia-reperfusion injury of rat liver grafts.

  2012cites this paper
• 5 Apoptosis Pathways in Ovarian Cancer

  2012cites this paper
• Roles of Kupffer cells in liver transplantation.

  2012cites this paper
• Protective role of nitric oxide induced by ischemic preconditioning on cold ischemic-reperfusion injury of rat liver graft.

  2012cites this paper
• Suppression of histone deacetylase 11 promotes expression of IL-10 in Kupffer cells and induces tolerance following orthotopic liver transplantation in rats.

  2012cites this paper
• Zinc finger protein A20 protects rats against chronic liver allograft dysfunction.

  2012cites this paper
• Dynamic changes of indoleamine 2,3-dioxygenase of Kupffer cells in rat liver transplant rejection and tolerance.

  2012cites this paper
• Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin‐10 through membrane‐bound TGF‐β

  2011cites this paper
• Expression of glucocorticoid-induced tumor necrosis factor receptor ligand in rat graft after liver transplantation.

  2011cites this paper
• Immunotherapeutic modulation of the suppressive liver and tumor microenvironments.

  2011cites this paper
• Advantages of promoting interleukin-10 by silence of histone deacetylase 11 in inducing tolerance in orthotopic liver transplantation in rats.

  2011cites this paper
• Endotoxin tolerance attenuates liver ischemia/reperfusion injury by down-regulation of interleukin-1 receptor-associated kinase 4 in kupffer cells.

  2011cites this paper
• Minimization of immunosuppression in adult liver transplantation: new strategies and tools

  2010cites this paper
• Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase.

  2010cites this paper
• Küpffer cells promote acute rejection via induction of Th17 differentiation in rat liver allografts.

  2010cites this paper
• Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats.

  2010cites this paper
• Immunosuppressive effect of IDO on T cells in patients with chronic hepatitis B *

  2009cites this paper
• Immunologic role of Kupffer cells in liver transplantation

  2009cites this paper
• Unique aspects of rejection and tolerance in liver transplantation.

  2009cites this paper