Huntingtin inclusion bodies are iron‐dependent centers of oxidative events

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The FEBS Journal

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1742-4658.2006.05537.xPMID 17116244
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of heat shock proteins during polyglutamine neurodegeneration

  2007cited by this paper
• Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake.

  2006cited by this paper
• Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

  2006cited by this paper
• Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant

  2006cited by this paper
• Expression of an expanded polyglutamine domain in yeast causes death with apoptotic markers.

  2006cited by this paper
• Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression.

  2005cited by this paper
• Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice

  2005cited by this paper
• Hsp27 Consolidates Intracellular Redox Homeostasis by Upholding Glutathione in Its Reduced Form and by Decreasing Iron Intracellular Levels

  2005cited by this paper
• Metal‐Catalyzed Disruption of Membrane Protein and Lipid Signaling in the Pathogenesis of Neurodegenerative Disorders

  2004cited by this paper
• Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins.

  2004cited by this paper
• Inefficient degradation of truncated polyglutamine proteins by the proteasome

  2004cited by this paper
• Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

  2004cited by this paper
• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

  2004cited by this paper
• Copper-dependent generation of hydrogen peroxide from the toxic prion protein fragment PrP106-126.

  2003cited by this paper
• Huntingtin aggregation and toxicity in Huntington's disease.

  2003cited by this paper
• In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

  2003cited by this paper
• Superoxide anion generation by the cytochrome bc1 complex.

  2003cited by this paper
• Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen‐dependent mechanism

  2003cited by this paper
• DNA damage induced by polyglutamine-expanded proteins.

  2003cited by this paper
• Hsp27 as a Negative Regulator of Cytochrome c Release

  2002cited by this paper
• Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease.

  2002cited by this paper
• Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment

  2002cited by this paper
• Purification of Polyglutamine Aggregates and Identification of Elongation Factor-1α and Heat Shock Protein 84 as Aggregate-Interacting Proteins

  2002cited by this paper
• Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

  2002cited by this paper
• Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease.

  2002cited by this paper
• Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.

  2002cited by this paper
• Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

  2002cited by this paper
• Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

  2002cited by this paper
• Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?

  2001cited by this paper
• Role of Free Radicals in the Neurodegenerative Diseases

  2001cited by this paper
• New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.

  2001cited by this paper
• Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.

  2001cited by this paper
• Glutamine repeats and neurodegenerative diseases: molecular aspects

  2001cited by this paper
• Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

  2001cited by this paper
• Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.

  2001cited by this paper
• Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.

  2001cited by this paper
• Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.

  2001cited by this paper
• [Huntington's disease: a bimolecular vision].

  2001cited by this paper
• Chemistry and biochemistry of oxidative stress in neurodegenerative disease.

  2001cited by this paper
• alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.

  2001cited by this paper
• Hsp27: Novel Regulator of Intracellular Redox State

  2001cited by this paper
• The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

  2000cited by this paper
• Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.

  2000cited by this paper
• Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

  2000cited by this paper
• The role of metals in neurodegenerative diseases.

  2000cited by this paper
• Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.

  2000cited by this paper
• Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease.

  2000cited by this paper
• Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila.

  2000cited by this paper
• Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

  2000cited by this paper
• Aggresomes, inclusion bodies and protein aggregation.

  2000cited by this paper
• Oxidative Stress, Antioxidants, and Alzheimer Disease

  2000cited by this paper
• Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.

  2000cited by this paper
• Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?

  2000cited by this paper
• Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery.

  1999cited by this paper
• In vitro and in vivo effects of genistein on murine alveolar macrophage TNF alpha production.

  1999cited by this paper
• Recent advances on the pathogenesis of Huntington's disease.

  1999cited by this paper
• Glutamine repeats and neurodegenerative diseases: molecular aspects.

  1999cited by this paper
• Protection of Neuronal Cells from Apoptosis by Hsp27 Delivered with a Herpes Simplex Virus-based Vector*

  1999cited by this paper
• Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis

  1999cited by this paper
• Oxidative Stress in Huntington's Disease

  1999cited by this paper
• In Vitro and In Vivo Effects of Genistein on Murine Alveolar Macrophage TNFα Production

  1999cited by this paper
• Mitochondrial dysfunction in neurodegenerative diseases.

  1998cited by this paper
• Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

  1998cited by this paper
• Neuronal cell death.

  1998cited by this paper
• Impaired clearance of oxidised proteins in neurodegenerative diseases.

  1998cited by this paper
• Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

  1998cited by this paper
• Free Radicals as Mediators of Neuronal Injury

  1998cited by this paper
• Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

  1997cited by this paper
• Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.

  1997cited by this paper
• Intranuclear Neuronal Inclusions : Minireview A Common Pathogenic Mechanism for Glutamine-Repeat Neurodegenerative Diseases ?

  1997cited by this paper
• Carbonyl assays for determination of oxidatively modified proteins.

  1994cited by this paper
• Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat

  1994cited by this paper
• PROTEIN SYNTHESIS IN VITRO IN NUCLEI OF HUMAN NERVOUS TISSUE

  1972cited by this paper

• Nuclear translocation of STAT5 initiates iron overload in huntington’s disease by up-regulating IRP1 expression

  2024cites this paper
• Microglia in Neurodegenerative Diseases.

  2024cites this paper
• Towards deciphering the Nt17 code: How the sequence and conformation of the first 17 amino acids in Huntingtin regulate the aggregation, cellular properties and neurotoxicity of mutant Httex1

  2021cites this paper
• The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1

  2021cites this paper
• Prolyl Oligopeptidase Inhibition Reduces Oxidative Stress via Reducing NADPH Oxidase Activity by Activating Protein Phosphatase 2A.

  2021cites this paper
• Mitochondrial iron metabolism and neurodegenerative diseases.

  2021cites this paper
• Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration

  2021cites this paper
• Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

  2020cites this paper
• Disentangling the sequence, cellular and ultrastructural determinants of Huntingtin nuclear and cytoplasmic inclusion formation

  2020cites this paper
• Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats.

  2019cites this paper
• Platelet abnormalities in Huntington’s disease

  2018cites this paper
• Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington’s disease patients

  2018cites this paper
• Molecular Pathogenesis in Huntington’s Disease

  2018cites this paper
• Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

  2018cites this paper
• Protein aggregation into insoluble deposits protects from oxidative stress

  2017cites this paper
• Polycyclic compounds as carriers for neuroactive non- steroidal anti-inflammatory drugs

  2017cites this paper
• Investigation into pathological neuronal-myeloid cell interactions and rescue of hyper-reactive immune responses in Huntington's disease

  2017cites this paper
• Amyloid Precursor Protein Haploinsufficiency Preferentially Mediates Brain Iron Accumulation in Mice Transgenic for The Huntington’s Disease Mutation

  2017cites this paper
• Metal Transporters in Neurodegeneration

  2017cites this paper
• Neonatal Iron Supplementation Induces Striatal Atrophy in Female YAC128 Huntington’s Disease Mice

  2016cites this paper
• Aggregation-promoting factors in neurodegenerative diseases

  2016cites this paper
• Role of iron in neurodegenerative diseases

  2016cites this paper
• Glyceraldehyde 3‐phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease

  2016cites this paper
• Studies of polyglutamine expanded Ataxin-7 toxicity

  2015cites this paper
• The choreography of neuroinflammation in Huntington's disease.

  2015cites this paper
• Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models

  2015cites this paper
• Studies of polyglutamine expanded Ataxin-7 toxicity

  2015cites this paper
• Gene–Environment Interactions in Huntington’s Disease

  2015cites this paper
• Molecular mechanism(s) underlying neurodegeneration in SCA7 disease : Role of NOX enzymes and oxidative stress

  2015cites this paper
• Immense Cellular Implications Associated to Small Stress Proteins Expression: Impacts on Human Pathologies

  2015cites this paper
• Quantifying iron levels in the YAC128 mouse model of Huntington's Disease

  2014cites this paper
• HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection.

  2014cites this paper
• Iron dysregulation in Huntington's disease

  2014cites this paper
• Mitochondrial Dysfunction in Brain and Muscle Pathology of Huntington’s Disease

  2014cites this paper
• The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders

  2014cites this paper
• AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.

  2014cites this paper
• Die Rolle von Mangan bei neurodegenerativen Erkrankungen

  2014cites this paper
• Metabolism in HD: Still a relevant mechanism?

  2014cites this paper
• Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis.

  2013cites this paper
• Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

  2013cites this paper
• The role of iron imaging in Huntington's disease.

  2013cites this paper
• hMTH1 expression protects mitochondria from Huntington's disease-like impairment

  2013cites this paper
• Abnormal iron homeostasis and neurodegeneration

  2013cites this paper
• The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations.

  2013cites this paper
• Altered manganese homeostasis and manganese toxicity in Huntington’s Disease striatal cell model are not due to defects in iron transport system

  2013cites this paper
• Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin.

  2012cites this paper
• Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

  2012cites this paper
• Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression: An Update

  2012cites this paper
• Energy dysfunction in Huntington's disease: insights from PGC-1a, AMPK, and CKB

  2012cites this paper
• Protein oxidation in Huntington disease

  2012cites this paper
• Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB

  2012cites this paper
• Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model

  2012cites this paper
• In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production*

  2011cites this paper
• Role of manganese in neurodegenerative diseases.

  2011cites this paper
• STUDIES OF FACTORS AFFECTING INTRACELLULAR TOXICITY OF THE SCA7 DISEASE PROTEIN ATAXIN - 7 : FOCUS ON ATAXIN-7 DEGRADATION AND OXIDATIVE STRESS

  2011cites this paper
• Studies of factors affecting the intracellular toxicity of the SCA7 disease protein Ataxin-7: Focus on Ataxin-7 Degradation and oxidative stress

  2011cites this paper
• Regulation of iron pathways in response to hypoxia.

  2011cites this paper
• Neuroinflammation in Huntington’s disease

  2010cites this paper
• La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse

  2010cites this paper
• Expression and functions of heat shock proteins in the normal and pathological mammalian eye.

  2010cites this paper
• Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.

  2010cites this paper
• Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity

  2010cites this paper
• Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

  2010cites this paper
• The transition metals copper and iron in neurodegenerative diseases.

  2010cites this paper
• Polyglutamine monomer structure and its implications for molecular self-assembly

  2009cites this paper
• [The molecular bases of Huntington's disease: the role played by oxidative stress].

  2009cites this paper
• Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

  2009cites this paper
• GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy

  2009cites this paper
• A Novel Pathophysiological Gene-Environment Interaction Suppresses the Neurotoxic Activities of (Mn) and Mutant HD

  2009cites this paper
• Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

  2008cites this paper
• Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease.

  2008cites this paper
• Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers.

  2008cites this paper
• Oxidative stress in neurodegeneration in dentatorubral-pallidoluysian atrophy.

  2008cites this paper
• Multi-target-directed ligands to combat neurodegenerative diseases.

  2008cites this paper
• Hsp27 (HspB1) and αB‐crystallin (HspB5) as therapeutic targets

  2007cites this paper
• Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.

  2007cites this paper
• Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

  2007cites this paper
• Erratum

  2007cites this paper
• Novel therapeutic strategies for the treatment of protein-misfolding diseases

  2007cites this paper
• Mechanisms of Copper Ion Mediated Huntington's Disease Progression

  2007cites this paper