β‐Adrenergic receptor desensitization of wild‐type but not cyc lymphoma cells unmasked by submillimolar Mg2+

No abstract is available for this paper.

• Publication year

  1987

• Venue

  The FASEB Journal

• Publication date

  1987-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fasebj.1.4.2820824PMID 2820824
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

  1987cited by this paper
• Desensitization of hormonal stimuli coupled to regulation of cyclic AMP levels.

  1986influential reference
• Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

  1986cited by this paper
• Discrimination between intact cell desensitization and agonist affinity changes.

  1986influential reference
• Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

  1986cited by this paper
• Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

  1986cited by this paper
• Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.

  1986cited by this paper
• Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model

  1985cited by this paper
• Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

  1985cited by this paper
• Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells.

  1985cited by this paper
• Receptor-specific mechanisms of desensitization of beta-adrenergic receptor function.

  1984cited by this paper
• Differential compartmentation of magnesium and calcium in murine S49 lymphoma cells.

  1984cited by this paper
• Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

  1984cited by this paper
• Receptor-specific mechanisms of desensitization of β-adrenergic receptor function

  1984cited by this paper
• Effects of desensitization on the responses of WI-38 and S49 cells to hormones.

  1984cited by this paper
• Agonist-induced changes in the properties of beta-adrenergic receptors on intact S49 lymphoma cells. Time-dependent changes in the affinity of the receptor for agonists.

  1984cited by this paper
• GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases.

  1984cited by this paper
• Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.

  1983cited by this paper
• Hormone‐sensitive magnesium transport in murine S49 lymphoma cells: characterization and specificity for magnesium

  1983cited by this paper
• Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

  1983cited by this paper
• Differences in the forskolin activation of adenylate cyclases in wild-type and variant lymphoma cells.

  1982cited by this paper
• Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides.

  1982influential reference
• Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

  1981cited by this paper
• Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells.

  1981cited by this paper
• Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.

  1980cited by this paper
• Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.

  1979cited by this paper
• The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.

  1978cited by this paper

• MODELLING β2AR REGULATION

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  2004cites this paper
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  2002cites this paper
• Analysis of domain responsible for desensitization of beta1-adrenergic receptor.

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• Pharmacological inhibition of protein kinases in intact cells: antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness.

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  1997cites this paper
• Regulation of G Protein–Coupled Receptors

  1997cites this paper
• Influence of receptor density on the patterns of beta2-adrenocepter desensitization.

  1997cites this paper
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  1996cites this paper
• Expression of Phosducin in a Phosducin-negative Cell Line Reveals Functions of a Gβγ-binding Protein*

  1996cites this paper
• Expression of phosducin in a phosducin-negative cell line reveals functions of a Gbetagamma-binding protein.

  1996cites this paper
• A Key Role for Protein Kinase A in Homologous Desensitization of the β2-Adrenergic Receptor Pathway in S49 Lymphoma Cells (*)

  1996cites this paper
• Measurement of adenylyl cyclase activity in cell membranes.

  1995cites this paper
• Modulation of Adenylylcyclase by Protein Kinase C in Human Neurotumor SK‐N‐MC Cells: Evidence that the α Isozyme Mediates Both Potentiation and Desensitization

  1994cites this paper
• Regulation of beta-agonist- and prostaglandin E2-mediated adenylyl cyclase activity in human airway epithelial cells.

  1994cites this paper
• Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled adenylyl cyclase in NS20Y neuroblastoma cells.

  1994cites this paper
• Growth of S49 wild type cells in 3 nM epinephrine increases cyclic AMP phosphodiesterase activity.

  1994cites this paper
• Differential expression of the beta-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation.

  1994cites this paper
• cAMP-dependent protein kinase and protein kinase C consensus site mutations of the beta-adrenergic receptor. Effect on desensitization and stimulation of adenylylcyclase.

  1994cites this paper
• The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization.

  1993cites this paper
• Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.

  1993cites this paper
• Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

  1993cites this paper
• Beta 2-adrenergic receptor mutants reveal structural requirements for the desensitization observed with long-term epinephrine treatment.

  1993cites this paper
• Molecular mechanisms of membrane receptor desensitization.

  1993cites this paper
• Chapter 5 The -adrenoceptors

  1993cites this paper
• Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.

  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
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  1992cites this paper
• Serum-induced sensitization of cyclic AMP accumulation in C62B rat glioma cells.

  1992cites this paper
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  1991cites this paper
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  1991cites this paper
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  1991cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1989cites this paper
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  1988cites this paper