Calmodulin mediates sulfur mustard toxicity in human keratinocytes.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Toxicology

• Publication date

  2006-10-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TOX.2006.06.019PMID 16935404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microarray Analysis of Mouse Ear Tissue Exposed to Bis-(2-chloroethyl) Sulfide: Gene Expression Profiles Correlate with Treatment Efficacy and An Established Clinical Endpoint

  2006cited by this paper
• Time‐ and dose‐dependent analysis of gene expression using microarrays in sulfur mustard‐exposed mice

  2005cited by this paper
• Microarray analysis of gene expression in murine skin exposed to sulfur mustard

  2005cited by this paper
• Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation.

  2005cited by this paper
• Fas Binding to Calmodulin Regulates Apoptosis in Osteoclasts*

  2005cited by this paper
• The ErbB2/Neu/HER2 receptor is a new calmodulin-binding protein.

  2004cited by this paper
• Calmodulin levels in psoriasis and other skin disorders

  2004cited by this paper
• Expression of Dominant-negative Fas-associated Death Domain Blocks Human Keratinocyte Apoptosis and Vesication Induced by Sulfur Mustard*

  2003cited by this paper
• Platelet calmodulin levels in adolescent idiopathic scoliosis. Do the levels correlate with curve progression and severity?

  2003cited by this paper
• Post-traumatic findings of the spine after earlier vertebral fractures in young patients.

  2003cited by this paper
• Platelet Calmodulin Levels in Adolescent Idiopathic Scoliosis: Do the Levels Correlate With Curve Progression and Severity?

  2002cited by this paper
• HPV-16 E6/7 Immortalization Sensitizes Human Keratinocytes to Ultraviolet B by Altering the Pathway from Caspase-8 to Caspase-9-dependent Apoptosis*

  2002cited by this paper
• Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis*

  2001cited by this paper
• PARP determines the mode of cell death in skin fibroblasts, but not keratinocytes, exposed to sulfur mustard.

  2001cited by this paper
• Calmodulin levels are dynamically regulated in living vascular smooth muscle cells.

  2001cited by this paper
• Effect of zinc on cellular levels of calmodulin and cyclic adenosine monophosphate in the adipocyte

  2000cited by this paper
• Treatment of skin injuries induced by sulfur mustard with calmodulin antagonists, using the pig model

  2000cited by this paper
• Differential regulation of calmodulin content and calmodulin messenger RNA levels by acute and repeated, intermittent amphetamine in dopaminergic terminal and midbrain areas.

  2000cited by this paper
• Calmodulin, poly(ADP–ribose)polymerase and p53 are targets for modulating the effects of sulfur mustard

  2000cited by this paper
• The polyepitope approach to DNA vaccination.

  1999cited by this paper
• Apoptosis and necrosis induced by sulfur mustard in Hela cells.

  1999cited by this paper
• Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity.

  1999cited by this paper
• Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.

  1998cited by this paper
• Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation.

  1998cited by this paper
• Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.

  1998cited by this paper
• Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3.

  1998cited by this paper
• Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization

  1998cited by this paper
• Calcium/Calmodulin-dependent Protein Kinase IV Is Cleaved by Caspase-3 and Calpain in SH-SY5Y Human Neuroblastoma Cells Undergoing Apoptosis*

  1998cited by this paper
• The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

  1998cited by this paper
• Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinocytes via a Ca2+-calmodulin and caspase-dependent pathway.

  1998cited by this paper
• Chemotherapeutic drug activation of the AP24 protease in apoptosis: requirement for caspase 3-like-proteases.

  1998cited by this paper
• Alterations in human lymphocyte DNA caused by sulfur mustard can be mitigated by selective inhibitors of poly(ADP-ribose) polymerase.

  1998cited by this paper
• The effects of altered cellular calmodulin expression on the growth and viability of C6 glioblastoma cells.

  1997cited by this paper
• Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

  1997cited by this paper
• Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

  1997cited by this paper
• BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity*

  1997cited by this paper
• Ca2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: evidence for direct inhibition of phospholipase C.

  1997cited by this paper
• DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.

  1997cited by this paper
• Sulfur mustard induces apoptosis and necrosis in endothelial cells.

  1996cited by this paper
• Thapsigargin, a weak skin tumor promoter, alters the growth and differentiation of mouse keratinocytes in culture.

  1996cited by this paper
• Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

  1996cited by this paper
• Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV.

  1996cited by this paper
• Effects of calmodulin antagonists and anesthetics on the skin lesions induced by 2-chloroethylethyl sulfide.

  1996cited by this paper
• DNA‐dependent protein kinase catalytic subunit: a target for an ICE‐like protease in apoptosis.

  1996cited by this paper
• Reduced level of calmodulin in PC12 cells induced by stable expression of calmodulin antisense RNA inhibits cell proliferation and induces neurite outgrowth.

  1996cited by this paper
• Role of calmodulin in HIV-potentiated Fas-mediated apoptosis.

  1996cited by this paper
• Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.

  1996cited by this paper
• Inactivation of Bcl-2 by phosphorylation.

  1995cited by this paper
• Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.

  1995cited by this paper
• Functional Elimination of Calmodulin within the Nucleus by Targeted Expression of an Inhibitor Peptide (*)

  1995cited by this paper
• Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro

  1995cited by this paper
• Sulfur mustard-induced increase in intracellular free calcium level and arachidonic acid release from cell membrane.

  1995cited by this paper
• Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

  1995cited by this paper
• Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

  1995cited by this paper
• Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans

  1993cited by this paper
• Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes.

  1993cited by this paper
• Sulfur Mustard-Induced Increase in Intracellular Calcium: A Mechanism of Mustard Toxicity

  1993cited by this paper
• Mutations in yeast calmodulin cause defects in spindle pole body functions and nuclear integrity

  1992cited by this paper
• Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.

  1992cited by this paper
• Epidermal calmodulin levels in psoriasis before & after therapy.

  1991cited by this paper
• Calmodulin levels in oestrogen receptor positive and negative human breast tumours.

  1991cited by this paper
• Flow cytometric analysis of toxicity by vesicating agents in human cells in vitro

  1991cited by this paper
• A human epidermal differentiation-specific keratin gene is regulated by calcium but not negative modulators of differentiation in transgenic mouse keratinocytes.

  1991cited by this paper
• Effect of the calmodulin antagonist CGS 9343B on skin burns.

  1991cited by this paper
• Effects of alkylating antineoplastics alone or in combination with 3-aminobenzamide on genotoxicity, antitumor activity, and NAD levels in human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo.

  1990cited by this paper
• The use of human epidermal keratinocytes in culture as a model for studying the biochemical mechanisms of sulfur mustard toxicity

  1990cited by this paper
• Effects of changes in calmodulin levels on cell proliferation.

  1990cited by this paper
• Ultrastructural Correlates of Sulfur Mustard Toxicity

  1990cited by this paper
• Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

  1989cited by this paper
• Treatment of frostbite with the calmodulin antagonists thioridazine and trifluoperazine.

  1989cited by this paper
• NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard.

  1989cited by this paper
• Calcium-activated DNA fragmentation in rat liver nuclei.

  1989cited by this paper
• Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.

  1989cited by this paper
• Multiple divergent mRNAs code for a single human calmodulin.

  1988cited by this paper
• Epidermal calmodulin levels and reference variables.

  1988cited by this paper
• The Molecular Biological Basis for the Response of Poly (ADP-RIB) Polymerase and NAD Metabolism to DNA Damage Caused by Mustard Alkylating Agents

  1988cited by this paper
• Epidermal calmodulin levels and reference variables.

  1988cited by this paper
• Calmodulin levels in psoriasis and other skin disorders.

  1987cited by this paper
• Letter to the EditorEpidermal Calmodulin Levels in Psoriasis

  1987cited by this paper
• Epidermal calmodulin levels in psoriasis.

  1987cited by this paper
• Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species.

  1987cited by this paper
• Isolation of the yeast calmodulin gene: calmodulin is an essential protein.

  1986cited by this paper
• Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry.

  1985cited by this paper
• Epidermal calmodulin levels in psoriasis.

  1985cited by this paper
• Isolation and nucleotide sequence of a cDNA encoding human calmodulin.

  1984cited by this paper
• Specific epidermal protein markers are modulated during calcium-induced terminal differentiation

  1983cited by this paper
• Proton-induced X-ray emission analysis - a new tool in quantitative dermatology.

  1983cited by this paper
• Naphthalenesulfonamides as calmodulin antagonists.

  1983cited by this paper
• The genetic toxicology of nitrogen and sulphur mustard.

  1980influential reference
• Calcium regulation of growth and differentiation of mouse epidermal cells in culture.

  1980cited by this paper
• [Treatment of psoriasis vulgaris with external sulfur mustard gas with particular reference to its potential carcinogenic risk. III. Clinical and experimental studies on the extent of percutaneous and inhalational uptake of sulfur mustard gas].

  1979cited by this paper

• Differential expression of apoptosis markers in early-phase sulfur mustard-induced pulmonary injuries

  2026cites this paper
• Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats

  2025cites this paper
• In vitro methods for evaluation of sulfur mustard on cell senescence.

  2025cites this paper
• A review of Sulfur Mustard-induced pulmonary immunopathology: An Alveolar Macrophage Approach.

  2020cites this paper
• NAD+ in sulfur mustard toxicity.

  2020cites this paper
• Dermal toxicity of sulfur mustard

  2020cites this paper
• Advances in treatment of acute sulfur mustard poisoning – a critical review

  2019cites this paper
• Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility.

  2018cites this paper
• Transient Receptor Potential Channel A1 (TRPA1) Regulates Sulfur Mustard-Induced Expression of Heat Shock 70 kDa Protein 6 (HSPA6) In Vitro

  2018cites this paper
• Roles of matrix metalloproteinases (MMPs) in SM-induced pathologies

  2018cites this paper
• Sulfur mustard skin lesions: A systematic review on pathomechanisms, treatment options and future research directions.

  2017cites this paper
• An evidence-based review of the genotoxic and reproductive effects of sulfur mustard

  2017cites this paper
• Chemical-induced alterations in the endocannabinoid system in mouse skin

  2016cites this paper
• Evaluation of Apoptosis in the Lung Tissue of Sulfur Mustard-exposed Individuals.

  2016cites this paper
• Caffeic acid, morin hydrate and quercetin partially attenuate sulfur mustard-induced cell death by inhibiting the lipoxygenase pathway.

  2016cites this paper
• Sulphur Mustard Induced Toxicity, Mechanism of Action and Current Medical Management

  2016cites this paper
• Dynamic cytotoxic profiles of sulfur mustard in human dermal cells determined by multiparametric high-content analysis.

  2016cites this paper
• Relationship of oxidative stress with male infertility in sulfur mustard-exposed injuries

  2016cites this paper
• Clinical Pharmacology and Toxicology of Mustard Compounds

  2015cites this paper
• Dermatologic Aspects of Sulfur Mustard Exposure

  2015cites this paper
• Genotoxicity, Teratogenicity and Mutagenicity of Sulfur Mustard Poisoning

  2015cites this paper
• Role of oxidative stress in sulfur mustard-induced pulmonary injury and antioxidant protection

  2015cites this paper
• Mechanism and treatment of sulfur mustard-induced cutaneous injury

  2014cites this paper
• Mustard Gas Inhalation Injury

  2014cites this paper
• Modified immunoslotblot assay to detect hemi and sulfur mustard DNA adducts.

  2013cites this paper
• Development of a mouse model for sulfur mustard-induced ocular injury and long-term clinical analysis of injury progression

  2013cites this paper
• Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: A review of molecular mechanisms

  2012cites this paper
• Haemostatic products as a potential therapy for vesicant-contaminated wounds

  2012cites this paper
• Involvement of calmodulin kinase II in the action of sulphur mustard on the contraction of vascular smooth muscle.

  2011cites this paper
• Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.

  2011cites this paper
• The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

  2011cites this paper
• Oxidative stress after sulfur mustard intoxication and its reduction by melatonin: efficacy of antioxidant therapy during serious intoxication

  2011cites this paper
• The role of homologous recombination in the cellular response to sulphur mustard.

  2010cites this paper
• Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop.

  2010cites this paper
• ulfur mustard induces apoptosis in lung epithelial cells via a caspase mplification

  2010cites this paper
• A large-scale quantitative proteomic approach to identifying sulfur mustard-induced protein phosphorylation cascades.

  2010cites this paper
• Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

  2010cites this paper
• Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.

  2010cites this paper
• Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering.

  2009cites this paper
• Microvesicating effects of sulfur mustard on an in vitro human skin model.

  2009cites this paper
• Sulphur mustard induces time- and concentration-dependent regulation of NO-synthesizing enzymes.

  2009cites this paper
• Medical Countermeasures and Other Therapeutic Strategies for Sulfur Mustard Toxicity

  2009cites this paper
• CHAPTER 41 – Dermal Toxicity of Sulfur Mustard

  2009cites this paper
• Proteomic assessment of sulfur mustard-induced protein adducts and other protein modifications in human epidermal keratinocytes.

  2008cites this paper
• Sulfur Mustard Induces Apoptosis in Cultured Normal Human Airway Epithelial Cells: Evidence of a Dominant Caspase-8-mediated Pathway and Differential Cellular Responses

  2008cites this paper
• Sulfur Mustard Research—Strategies for the Development of Improved Medical Therapy

  2008cites this paper
• Addition of Epidermal Growth Factor Improves the Rate of Sulfur Mustard Wound Healing in an In Vitro Model

  2008cites this paper
• Signaling Molecules in Sulfur Mustard-Induced Cutaneous Injury

  2007cites this paper
• Dermal Toxicology Specialty Section

  2005cites this paper
• Review Paper Therapeutic Challenges in Sulfur Mustard Induced Pulmonary Complications and Mesenchymal Stem Cells

  year unknowncites this paper