Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.

G. Roma,M. Di Braccio,G. Grossi,D. Piras,G. Leoncini,D. Bruzzese,M. Signorello,P. Fossa,L. Mosti

Published 2007 in Journal of Medicinal Chemistry

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