Zika virus and neurological disease—approaches to the unknown

T. Solomon,M. Baylis,David W. G. Brown

Published 2016 in Lancet. Infectious Diseases (Print)

ABSTRACT

Overcoming the cost or logistical issues for the mass production of these vaccines is now urgent. In conclusion, much progress has been made in control of meningococcal disease outbreaks in the meningitis belt of Africa. However, it is now evident that a monovalent conjugate vaccine is only a palliative solution and multivalent, protein conjugate or novel DNA vaccines are urgently needed in quantities that can be off ered routinely to at least the most vulnerable people in this region. It is concerning that the clone that caused the recent outbreak of serogroup C disease originated from Nigeria, where poor vaccine acceptability for poliomyelitis has cost the world a great toll in eradication of this infection. It is prudent to pay particular attention now, given the size of the population at risk here, because without adequate control at this location we might have a cesspool for meningococcal genetic recombination for future outbreaks within the region.

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