Selenocysteine confers resistance to inactivation by oxidation in thioredoxin reductase: comparison of selenium and sulfur enzymes.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biochemistry

• Publication date

  2013-07-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/bi400462jPMID 23865454PMCID PMC3760785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selective Metabolism of Hypothiocyanous Acid by Mammalian Thioredoxin Reductase Promotes Lung Innate Immunity and Antioxidant Defense*

  2013cited by this paper
• Selenocysteine in Thiol/Disulfide-Like Exchange Reactions

  2013cited by this paper
• A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid.

  2011cited by this paper
• Differing views of the role of selenium in thioredoxin reductase

  2011cited by this paper
• Chemical Basis for the Use of Selenocysteine

  2011cited by this paper
• Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

  2011cited by this paper
• Metabolic , Endocrine and Genitourinary Pathobiology Oxidative Stress A Required Condition for Thyroid Cell Proliferation

  2010cited by this paper
• The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

  2010cited by this paper
• Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism.

  2010cited by this paper
• Selenium and sulfur in exchange reactions: a comparative study.

  2010cited by this paper
• The three-dimensional structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough: a hydrogenase without a bridging ligand in the active site in its oxidised, "as-isolated" state.

  2010cited by this paper
• Why do proteins use selenocysteine instead of cysteine?

  2010cited by this paper
• Peroxynitrite mediates active site tyrosine nitration in manganese superoxide dismutase. Evidence of a role for the carbonate radical anion.

  2010cited by this paper
• Methaneseleninic acid is a substrate for truncated mammalian thioredoxin reductase: implications for the catalytic mechanism and redox signaling.

  2010cited by this paper
• Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme.

  2009cited by this paper
• The difference a Se makes? Oxygen-tolerant hydrogen production by the [NiFeSe]-hydrogenase from Desulfomicrobium baculatum.

  2008cited by this paper
• Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

  2008influential reference
• Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases.

  2007cited by this paper
• Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis.

  2007cited by this paper
• Use of Electron Paramagnetic Resonance Spectroscopy to Evaluate the Redox State In Vivo

  2007cited by this paper
• Selenocysteine versus cysteine reactivity: a theoretical study of their oxidation by hydrogen peroxide.

  2007cited by this paper
• Selenium in chemistry and biochemistry in comparison to sulfur

  2007cited by this paper
• Semisynthesis and characterization of mammalian thioredoxin reductase.

  2006cited by this paper
• Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: II. Expression and Role of Flavin-Containing Monooxygenases and Peroxidases

  2006cited by this paper
• Synthesis of peroxynitrite using isoamyl nitrite and hydrogen peroxide in a homogeneous solvent system.

  2006cited by this paper
• The thioredoxin system—From science to clinic

  2004cited by this paper
• Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy

  2004cited by this paper
• Non‐animal origin of animal thioredoxin reductases: Implications for selenocysteine evolution and evolution of protein function through carboxy‐terminal extensions

  2003cited by this paper
• Hypochlorite-induced oxidation of amino acids, peptides and proteins

  2003cited by this paper
• ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

  2003cited by this paper
• Spin traps: in vitro toxicity and stability of radical adducts.

  2003cited by this paper
• Radiolytic modification of basic amino acid residues in peptides: probes for examining protein-protein interactions.

  2003cited by this paper
• Active sites of thioredoxin reductases: Why selenoproteins?

  2003cited by this paper
• Peroxynitrite Inactivates the Human Dopamine Transporter by Modification of Cysteine 342: Potential Mechanism of Neurotoxicity in Dopamine Neurons

  2002cited by this paper
• Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

  2001cited by this paper
• Substituting Selenocysteine for Catalytic Cysteine 41 Enhances Enzymatic Activity of Plant Phospholipid Hydroperoxide Glutathione Peroxidase Expressed in Escherichia coli *

  2000cited by this paper
• Physiological effects of peroxynitrite: potential products of the environment.

  2000cited by this paper
• Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes.

  2000cited by this paper
• Translation: The twenty-first amino acid

  2000cited by this paper
• Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations*

  2000cited by this paper
• Function of thioredoxin reductase as a peroxynitrite reductase using selenocystine or ebselen.

  1999cited by this paper
• Peroxynitrite modification of protein thiols: oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase.

  1999cited by this paper
• Kinetic study of the reaction of glutathione peroxidase with peroxynitrite.

  1998cited by this paper
• Peroxynitrite‐mediated DNA strand breakage activates poly (ADP‐ribose) synthetase and causes cellular energy depletion in carrageenan‐induced pleurisy

  1998cited by this paper
• Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

  1997cited by this paper
• Sensitivity of protein sulfhydryl repair enzymes to oxidative stress.

  1997cited by this paper
• Synthesis of selenocysteine peptides and their oxidation to diselenide‐bridged compounds

  1997cited by this paper
• Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite.

  1996cited by this paper
• DNA damage by peroxynitrite characterized with DNA repair enzymes.

  1996cited by this paper
• Reactions of monochloramine with bromine, tribromide, hypobromous acid and hypobromite: formation of bromochloramines

  1994cited by this paper
• On the protective mechanism of the thiol-specific antioxidant enzyme against the oxidative damage of biomacromolecules.

  1994cited by this paper
• Reactions of Monochloramine with Br2, Br- 3, HOBr, and OBr-: Formation of Bromochloramines.

  1994cited by this paper
• Crystal structure of selenosubtilisin at 2.0-A resolution.

  1993cited by this paper
• Non‐Metal Redox Kinetics: Hypobromite and Hypobromous Acid Reactions with Iodide and with Sulfite and the Hydrolysis of Bromosulfate.

  1991cited by this paper
• Selenocysteine: the 21st amino acid

  1991cited by this paper
• Genetic code 1990.

  1990cited by this paper
• Genetic code 1990. Outlook

  1990cited by this paper
• Gene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine

  1988cited by this paper
• Radical driven Fenton reactions--evidence from paraquat radical studies for production of tetravalent iron in the presence and absence of ethylenediaminetetraacetic acid.

  1987cited by this paper
• Reaction of alanine-3-sulfinic acid with 2-mercaptoethanol

  1979cited by this paper
• The chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid

  1968cited by this paper

• Old Friends, New Faces in Endothelial Dysfunction and Senescence.

  2026cites this paper
• Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and GPX4 Mediated Immune Regulation Through Autophagy in Solid Tumors

  2025cites this paper
• Selenium and Selenoproteins in Neutrophil Functions.

  2025cites this paper
• The Role of Selenocysteine in Catalysis and Oxygen Tolerance of a W-Dependent Formate Dehydrogenase

  2025cites this paper
• Chalcogen Bonding Boosts the Uptake of Small Molecules in Mammalian Cells.

  2025cites this paper
• Selenium Nucleophilicity and Electrophilicity in the Intra‐ and Intermolecular SN2 Reactions of Selenenyl Sulfide Probes

  2025cites this paper
• Noncanonical Amino Acids in Biocatalysis

  2024cites this paper
• Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology

  2024cites this paper
• Engineered mRNA–ribosome fusions for facile biosynthesis of selenoproteins

  2024cites this paper
• Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA‐Seq Analysis

  2024cites this paper
• Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences

  2024cites this paper
• 50 Years of Organoselenium Chemistry, Biochemistry and Reactivity: Mechanistic Understanding, Successful and Controversial Stories

  2024cites this paper
• Modulation of Antioxidant Enzyme Expression of In Vitro Culture-Derived Reticulocytes

  2024cites this paper
• Fast Intramolecular Thiol-Activated Arylselenoamides Provide Access to Triggered, Fluorogenic H2Se Donors.

  2024cites this paper
• Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children

  2023cites this paper
• Comparative analysis of CO2 reduction by soluble Escherichia coli formate dehydrogenase H and its selenocysteine-to-cysteine substitution variant

  2023cites this paper
• Structural basis for the tRNA-dependent activation of the terminal complex of selenocysteine synthesis in humans

  2023cites this paper
• An accelerated and optimized algorithm of selenium-encoded isotopic signature targeted profiling for global selenoproteome analysis.

  2022cites this paper
• The selenocysteine toolbox: A guide to studying the 21st amino acid.

  2022cites this paper
• Voyage of selenium from environment to life: Beneficial or toxic?

  2022cites this paper
• Escherichia coli RclA is a highly active hypothiocyanite reductase

  2022cites this paper
• New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease

  2022influential citation
• Probing the Role of Cysteine Thiyl Radicals in Biology: Eminently Dangerous, Difficult to Scavenge

  2022cites this paper
• Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?

  2022cites this paper
• Cysteine-Activated Small-Molecule H2Se Donors Inspired by Synthetic H2S Donors.

  2022cites this paper
• Chemoproteomic interrogation of selenocysteine by low-pH isoTOP-ABPP.

  2022cites this paper
• Application of alpha-methyl selenocysteine as a tool for the study of selenoproteins.

  2022cites this paper
• Using selenocysteine-specific reporters to screen for efficient tRNASec variants.

  2022cites this paper
• Intein-based design expands diversity of selenocysteine reporters.

  2021cites this paper
• Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage.

  2021cites this paper
• The physiology and evolution of microbial selenium metabolism.

  2021cites this paper
• Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology

  2021cites this paper
• Recoding of stop codons expands the metabolic potential of two novel Asgardarchaeota lineages

  2021cites this paper
• Exploring the selenium-over-sulfur substrate specificity and kinetics of a bacterial selenocysteine lyase

  2020cites this paper
• Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review

  2020cites this paper
• Selenium: Tracing Another Essential Element of Ferroptotic Cell Death.

  2020cites this paper
• Predicting the Possible Physiological/Biological Utility of the Hydropersulfide Functional Group Based on Its Chemistry: Similarities Between Hydropersulfides and Selenols

  2020cites this paper
• Studies of the thioredoxin system in redox signaling and oxidative stress

  2020cites this paper
• Studies on the reaction between reduced riboflavin and selenocystine

  2020cites this paper
• Can selenoenzymes resist electrophilic modification? Evidence from thioredoxin reductase and a mutant containing alpha-methylselenocysteine.

  2020cites this paper
• Protein Modifications | Biosynthesis of Selenoproteins

  2020cites this paper
• Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.

  2019cites this paper
• The science of licking your wounds: Function of oxidants in the innate immune system.

  2019cites this paper
• Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins

  2019cites this paper
• A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.

  2019cites this paper
• Selenium vs. Sulfur: Investigating the Substrate Specificity of a Selenocysteine Lyase

  2019cites this paper
• Selenium nanoparticles are less toxic than inorganic and organic selenium to mice in vivo

  2019cites this paper
• Chemoenzymatic Semisynthesis of Proteins.

  2019cites this paper
• Challenges of site-specific selenocysteine incorporation into proteins by Escherichia coli

  2018cites this paper
• Improving redox sensitivity of roGFP1 by incorporation of selenocysteine at position 147

  2018cites this paper
• Organoselenium in Nature

  2018cites this paper
• Selenium-Encoded Isotopic Signature Targeted Profiling

  2018cites this paper
• Gain of function conferred by selenocysteine: catalytic enhancement of one‐electron transfer reactions by thioredoxin reductase

  2018cites this paper
• A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome.

  2018cites this paper
• Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology

  2018cites this paper
• Selenium at the redox interface of the genome, metabolome and exposome.

  2018cites this paper
• Selenoprotein synthesis and regulation in Archaea.

  2018cites this paper
• Selenium versus sulfur: Reversibility of chemical reactions and resistance to permanent oxidation in proteins and nucleic acids.

  2018cites this paper
• Distinct Patterns of Selection in Selenium-Dependent Genes between Land and Aquatic Vertebrates

  2018cites this paper
• Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress.

  2018cites this paper
• A "Seleno Effect" Differentiates the Roles of Redox Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase.

  2018cites this paper
• Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology.

  2017cites this paper
• Selenium and Selenocysteine in Protein Chemistry.

  2017cites this paper
• The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis.

  2017cites this paper
• Mycochemical Changes Induced by Selenium Enrichment in P. ostreatus Fruiting Bodies.

  2017cites this paper
• NANOMATERIALS-BASED SENSORS FOR PEROXYNITRITE DETECTION AND QUANTIFICATION

  2017cites this paper
• Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

  2017influential citation
• Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate

  2017cites this paper
• Comparison of the redox chemistry of sulfur‐ and selenium‐containing analogs of uracil

  2017cites this paper
• Selen und Selenocystein in der Proteinchemie

  2017cites this paper
• Biokatalyse mit nicht‐natürlichen Aminosäuren: Enzymologie trifft Xenobiologie

  2017cites this paper
• Electrochemical Study of Selenocystine Reactivity and Reduction at Metallic Surfaces

  2017cites this paper
• Genetic Adaptation and Selenium Uptake in Vertebrates

  2017cites this paper
• The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites

  2017cites this paper
• Alteration of Selenoprotein Expression During Stress and in Aging

  2016cites this paper
• Leichte Neucodierung von Selenocystein in der Natur

  2016cites this paper
• Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro

  2016cites this paper
• Selenium Toxic and Essential

  2016cites this paper
• Why Nature Chose Selenium.

  2016cites this paper
• Selenols are resistant to irreversible modification by HNO.

  2016cites this paper
• [Facile Recoding of Selenocysteine in Nature].

  2016cites this paper
• Facile Recoding of Selenocysteine in Nature.

  2016cites this paper
• Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology

  2015cites this paper
• Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health

  2015cites this paper
• Induction of a proton gradient across a gold-supported biomimetic membrane by electroenzymatic H2 oxidation.

  2015cites this paper
• TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

  2015cites this paper
• Genetic adaptation to levels of dietary selenium in recent human history.

  2015cites this paper
• Reaction of low-molecular-mass organoselenium compounds (and their sulphur analogues) with inflammation-associated oxidants

  2015cites this paper
• Differentiating the Roles of Redox-Active Cysteine Residues in Plasmodium falciparum Thioredoxin Reductase by using a "Seleno Effect"

  2015cites this paper
• Towards Sense Codon Reassignment in Escherichia Coli

  2015cites this paper
• Membrane-Bound Selenoproteins

  2015cites this paper
• Intricate aspects of the thioredoxin system in redox signaling

  2014cites this paper
• Why selenocysteine replaces cysteine in thioredoxin reductase: a radical hypothesis.

  2014cites this paper
• Selenoproteins: molecular pathways and physiological roles.

  2014cites this paper
• Glutathione peroxidase's reaction intermediate selenenic acid is stabilized by the protein microenvironment.

  2014cites this paper
• Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

  2014influential citation
• Recoding the genetic code with selenocysteine.

  2014cites this paper
• Umkodierung des genetischen Codes mit Selenocystein

  2014cites this paper
• Selenoproteins and selenium status in bone physiology and pathology.

  2014cites this paper
• Mitochondrial structure and function as a therapeutic target in malignant mesothelioma

  2014cites this paper