Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Pain

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1097/j.pain.0000000000001083PMID 29076919PMCID PMC6764446
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain.

  2017influential reference
• KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

  2016cited by this paper
• Investigating generalizability of results from a randomized controlled trial of the management of chronic widespread pain: the MUSICIAN study

  2016cited by this paper
• Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

  2016cited by this paper
• Modulation of pain, nociception, and analgesia by the brain reward center.

  2016cited by this paper
• BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats

  2016cited by this paper
• Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

  2015cited by this paper
• Nociception, Pain, Negative Moods, and Behavior Selection.

  2015cited by this paper
• Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain

  2015cited by this paper
• Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

  2015cited by this paper
• Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors

  2015cited by this paper
• Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain

  2015cited by this paper
• Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain

  2015cited by this paper
• Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms.

  2015cited by this paper
• Nociception , Pain , Negative Moods , and Behavior Selection

  2015cited by this paper
• Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats.

  2014cited by this paper
• Enhanced Medial Prefrontal-Default Mode Network Functional Connectivity in Chronic Pain and Its Association with Pain Rumination

  2014cited by this paper
• The antero-posterior heterogeneity of the ventral tegmental area.

  2014cited by this paper
• Valence-Specific Effects of BDNF Val66Met Polymorphism on Dopaminergic Stress and Reward Processing in Humans

  2014cited by this paper
• Reward and aversion in a heterogeneous midbrain dopamine system.

  2014cited by this paper
• BDNF: no gain without pain?

  2014cited by this paper
• Pain vulnerability: a neurobiological perspective

  2014cited by this paper
• Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

  2014cited by this paper
• Circuit dynamics of adaptive and maladaptive behaviour

  2014cited by this paper
• The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context.

  2014cited by this paper
• The brain reward circuitry in mood disorders

  2013cited by this paper
• Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

  2013cited by this paper
• Impacts of early intervention with fluoxetine following early neonatal immune activation on depression-like behaviors and body weight in mice.

  2013cited by this paper
• Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors

  2012cited by this paper
• Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

  2012cited by this paper
• Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre‐exposure

  2012cited by this paper
• Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons

  2012cited by this paper
• Corticostriatal functional connectivity predicts transition to chronic back pain

  2012cited by this paper
• The nucleus accumbens as a potential target for central poststroke pain.

  2012cited by this paper
• Pain-related changes in the brain: diagnostic and therapeutic potentials.

  2012cited by this paper
• Dopamine neurons modulate neural encoding and expression of depression-related behaviour

  2012cited by this paper
• Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents.

  2012cited by this paper
• Nucleus accumbens facilitates nociception.

  2011cited by this paper
• Neuronal circuits underlying acute morphine action on dopamine neurons

  2011cited by this paper
• Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli.

  2011cited by this paper
• Change in MicroRNAs Associated with Neuronal Adaptive Responses in the Nucleus Accumbens under Neuropathic Pain

  2011cited by this paper
• Lack of promoter IV‐driven BDNF transcription results in depression‐like behavior

  2010cited by this paper
• Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action

  2010cited by this paper
• BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

  2010cited by this paper
• Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

  2010cited by this paper
• Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans

  2010cited by this paper
• Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.

  2010cited by this paper
• Increased thermal and mechanical nociceptive thresholds in rats with depressive-like behaviors.

  2010cited by this paper
• Brain-derived neurotrophic factor: role in depression and suicide

  2009cited by this paper
• Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

  2009cited by this paper
• Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli

  2009cited by this paper
• VTA Dopamine Neuron Bursting is Altered in an Animal Model of Depression and Corrected by Desipramine

  2008cited by this paper
• Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D2 Receptor Inhibition

  2008cited by this paper
• Dual Role of Medial A10 Dopamine Neurons in Affective Encoding

  2008cited by this paper
• Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.

  2008cited by this paper
• New insights into BDNF function in depression and anxiety

  2007cited by this paper
• Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.

  2007cited by this paper
• RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area

  2007cited by this paper
• Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

  2006cited by this paper
• Activation of TRPV1 in the VTA Excites Dopaminergic Neurons and Increases Chemical- and Noxious-Induced Dopamine Release in the Nucleus Accumbens

  2005cited by this paper
• Restraint Increases Dopaminergic Burst Firing in Awake Rats

  2005cited by this paper
• Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex.

  2005cited by this paper
• Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system

  2004cited by this paper
• Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli

  2004cited by this paper
• Chronic unpredictable stress inhibits nociception in male rats.

  2004cited by this paper
• The role of dopamine in the nucleus accumbens in analgesia.

  1999cited by this paper
• Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine.

  1998cited by this paper
• Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats

  1990cited by this paper
• A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

  1987cited by this paper

• Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels.

  2026cites this paper
• An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice.

  2025cites this paper
• Anxiety Promotes Occlusal Interference-Induced Myalgia via the Mesolimbic System.

  2025cites this paper
• Chemokine CCL2 Mediates Neuroglial Crosstalk and Drives Chronic Pain Pathogenesis

  2025cites this paper
• Advances in neurotransmitter-mediated prefrontal circuitry in depression.

  2025cites this paper
• Brain-derived neurotrophic factor in the ventrolateral orbital cortex regulates spared nerve injury-induced neuropathic pain and related emotional disorders in mice.

  2025cites this paper
• Untangling the multifaceted VTA responses to stress.

  2025cites this paper
• BDNF Signaling and Pain Modulation

  2025influential citation
• Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction

  2025cites this paper
• Temporomandibular disorders and mental health: shared etiologies and treatment approaches

  2025cites this paper
• VTA Dopaminergic Neurons involved in Chronic Spared Nerve Injury Pain-induced Depressive-like Behavior.

  2025cites this paper
• How does chronic psychosocial distress induce pain? Focus on neuroinflammation and neuroplasticity changes.

  2025cites this paper
• Chronic Pain and Comorbid Emotional Disorders: Neural Circuitry and Neuroimmunity Pathways

  2025cites this paper
• Neural circuits mediating chronic stress: Implications for major depressive disorder.

  2025cites this paper
• BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended.

  2024cites this paper
• A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice

  2024cites this paper
• Prefrontal cortical circuits in social behaviors: an overview

  2024cites this paper
• Research progress in inflammation and reward mechanisms and traditional Chinese medicine regulation of depression

  2024cites this paper
• Unraveling the Pathogenesis of Post‐Stroke Depression in a Hemorrhagic Mouse Model through Frontal Lobe Circuitry and JAK‐STAT Signaling

  2024cites this paper
• The Roles of Endogenous Opioids in Placebo and Nocebo Effects: From Pain to Performance to Prozac.

  2024cites this paper
• Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

  2024cites this paper
• Mitochondrial dysfunction: mechanisms and advances in therapy

  2024cites this paper
• CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission

  2024cites this paper
• α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata

  2024cites this paper
• The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

  2024cites this paper
• Analysis of Protein Markers in Plasma of Patients with Drug Dependence Syndrome: Observational Clinical Study

  2023cites this paper
• Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice

  2023cites this paper
• Pain-related cortico-limbic plasticity and opioid signaling.

  2023cites this paper
• Neural and Molecular Investigation into the Paraventricular Thalamic-Nucleus Accumbens Circuit for Pain Sensation and Non-opioid Analgesia.

  2023cites this paper
• Disinhibition of Mesolimbic Dopamine Circuit by the Lateral Hypothalamus Regulates Pain Sensation

  2023cites this paper
• Caveolin-1 is essential for the increased release of glutamate in the anterior cingulate cortex in neuropathic pain mice.

  2023cites this paper
• Direct paraventricular thalamus-basolateral amygdala circuit modulates neuropathic pain and emotional anxiety

  2023cites this paper
• AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal

  2023cites this paper
• An Ascending Excitatory Circuit from the Dorsal Raphe for Sensory Modulation of Pain

  2023cites this paper
• Multiple integrated social stress induces depressive-like behavioral and neural adaptations in female C57BL/6J mice.

  2023cites this paper
• Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors

  2022influential citation
• The VTA-BLA-NAc circuit for sex reward inhibited by VTA GABAergic neurons under stress in male mice

  2021cites this paper
• Dopaminergic Neurons in the Ventral Tegmental–Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia

  2021cites this paper
• Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain

  2021cites this paper
• Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

  2021cites this paper
• Microglia and HPA axis in depression: An overview of participation and relationship

  2021cites this paper
• CCL2/CCR2 Contributes to the Altered Excitatory-inhibitory Synaptic Balance in the Nucleus Accumbens Shell Following Peripheral Nerve Injury-induced Neuropathic Pain

  2021cites this paper
• KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice

  2021cites this paper
• Projection-specific dopamine neurons in the ventral tegmental area participated in morphine-induced hyperalgesia and anti-nociceptive tolerance in male mice

  2021cites this paper
• Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

  2021cites this paper
• Chronic Pain Impairs Memory Formation via Disruption of Neurogenesis Mediated by Mesohippocampal Brain-Derived Neurotrophic Factor Signaling.

  2020cites this paper
• MKP1 in the medial prefrontal cortex modulates chronic neuropathic pain via regulation of p38 and JNK1/2

  2020cites this paper
• Optogenetics: The Key to Deciphering and Curing Neurological Diseases

  2020cites this paper
• Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain.

  2020cites this paper
• Fetal growth restriction mice are more likely to exhibit depression‐like behaviors due to stress‐induced loss of dopaminergic neurons in the VTA

  2020cites this paper
• The duration of the antidepressant-like effects of a single infusion of brain-derived neurotrophic factor into the medial prefrontal cortex in mice.

  2020cites this paper
• Mesocortical BDNF signaling mediates antidepressive-like effects of lithium

  2020cites this paper
• Neuropathic Pain Linked to Defective Dopaminergic Inhibition in Anterior Cingulate Cortex

  2020cites this paper
• The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities.

  2020cites this paper
• Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain

  2019cites this paper
• The molecular neurobiology of chronic pain–induced depression

  2019cites this paper
• Screening for physical and behavioral dependence on non-opioid analgesics in a German elderly hospital population.

  2019cites this paper
• EFFECTS OF PREDATOR INDUCED PSYCHOSOCIAL STRESS ON SPERM PARAMETERS OF ALBINO WISTAR RATS

  2019cites this paper
• Antidepressant effects of ketamine on depression-related phenotypes and dopamine dysfunction in rodent models of stress.

  2019cites this paper
• Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors.

  2019cites this paper
• Alterations and adaptation of ventral tegmental area dopaminergic neurons in animal models of depression

  2019cites this paper
• Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression.

  2019influential citation
• The Effects of Chronic Stress on Migraine Relevant Phenotypes in Male Mice

  2018cites this paper
• Biological and Psychological Perspectives of Resilience: Is It Possible to Improve Stress Resistance?

  2018cites this paper