The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Cytogenetics and Cell Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000134720PMID 9605850
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Organic cation transporters in intestine, kidney, liver, and brain.

  1998cited by this paper
• Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter*

  1997cited by this paper
• Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters

  1997cited by this paper
• Primary Structure and Functional Expression of the Apical Organic Cation Transporter from Kidney Epithelial LLC-PK1Cells*

  1997cited by this paper
• Cloning and functional expression of a human liver organic cation transporter.

  1997cited by this paper
• Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney*

  1997cited by this paper
• cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.

  1996cited by this paper
• The Lxl gene maps to mouse Chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters

  1996cited by this paper
• Roct1, a rat polyspecific transporter gene for the excretion of cationic drugs, maps to Chromosome 1q11-12

  1996cited by this paper
• Electrogenic Properties and Substrate Specificity of the Polyspecific Rat Cation Transporter rOCT1*

  1996cited by this paper
• A YAC contig map of the human genome.

  1995cited by this paper
• A rat genetic linkage map and comparative maps for mouse or human homologous rat genes

  1994cited by this paper
• Drug excretion mediated by a new prototype of polyspecific transporter

  1994cited by this paper
• A 2-Mb YAC contig linking the plasminogen-apoprotein(a) gene family to the insulin-like growth factor 2 receptor (IGF2R) gene on the telomeric region of chromosome 6 (6q26-q27).

  1994cited by this paper
• Digitized and differentially shaded human chromosome ideograms for genomic applications.

  1994cited by this paper
• NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2.

  1993cited by this paper
• Characterization of NIGMS human/rodent somatic cell hybrid mapping panel 2 by PCR.

  1993cited by this paper
• A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.

  1993cited by this paper
• Linkage and synteny homologies in mouse and man.

  1988cited by this paper

• Role of OCT1 and MAP3K5 Genetic Polymorphisms in Hydroxyurea Pharmacokinetics

  2025cites this paper
• Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape

  2023cites this paper
• Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis

  2023cites this paper
• Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes

  2023cites this paper
• Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

  2021cites this paper
• Drug-Drug Interactions at Organic Cation Transporter 1

  2021cites this paper
• Organic Cation Transporters in Health and Disease

  2020influential citation
• OTT_A_212088 6013..6022

  2019cites this paper
• Role of OCT1 in hepatocellular carcinoma

  2019cites this paper
• Effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels

  2018cites this paper
• Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes

  2018cites this paper
• 10.25 – Uptake Transporters

  2018cites this paper
• Large-scale identification of differentially expressed genes during pupa development reveals solute carrier gene is essential for pupal pigmentation in Chilo suppressalis.

  2017cites this paper
• Organic Cation Transporter 2 (OCT2/SLC22A2) Gene Variation in the South African Bantu-Speaking Population and Functional Promoter Variants

  2017cites this paper
• Functional and molecular analysis of Organic Cation Transporters (OCTs and OCTNs) in human airway epithelial cells and macrophages

  2017cites this paper
• Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation

  2016influential citation
• Introduction to the Cellular Transport of Organic Cations

  2016cites this paper
• The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations

  2016cites this paper
• Metformin and the gastrointestinal tract

  2016cites this paper
• Genomic diversity and functional analysis of the solute carrier genes within indigenous African and Cape Admixed populations

  2016cites this paper
• Characterization of organic cation transporters in zebrafish (Danio rerio)

  2015cites this paper
• Thiamine dependency and related gene mutations: recent aspects

  2015cites this paper
• Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

  2015cites this paper
• Substrate Influence on Ligand Interaction with the Human Multidrug And Toxin Extruder (MATE)

  2015cites this paper
• Single nucleotide polymorphisms of the SLC22A2 gene within the Xhosa population of South Africa.

  2015cites this paper
• Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research

  2014cites this paper
• Overview of Drug Transporter Families

  2014cites this paper
• Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa

  2014cites this paper
• Expression profile and pharmacogenetics of genes candidate to play a role in cardiovascular disease

  2014cites this paper
• Organic Anion and Cation Transporters in Renal Elimination of Drugs

  2013cites this paper
• Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells.

  2013cites this paper
• Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology

  2013cites this paper
• OCT (SLC22A) and OCTN Family

  2013cites this paper
• The Pharmacogenomics of Membrane Transporters Project

  2013cites this paper
• The role of organic cation transporters in the nasal uptake and brain distribution of organic cation substrates

  2013cites this paper
• IDENTIFICATION OF GENETIC POLYMORPHISMS ASSOCIATED WITH OESOPHAGEAL SQUAMOUS CELL CARCINOMA RISK IN SOUTH AFRICA

  2013cites this paper
• Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

  2012cites this paper
• Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.

  2011cites this paper
• SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells

  2011cites this paper
• The Role of Multidrug And Toxin Extrusion (MATE) in Renal Organic Cation Secretion

  2011cites this paper
• Robust Electrophysiological Assays using Solid Supported Membranes: the Organic Cation Transporter OCT2

  2011cites this paper
• Human Multidrug and Toxin Extrusion Protein 1: Symmetry of substrate fluxes

  2011cites this paper
• Factors affecting metformin plasma concentrations

  2010cites this paper
• Aufnahme und Metabolismus von 6-Fluoro-DOPA und 6-Fluoro-Dopamin in Neuroblastomzellen und

  2010cites this paper
• 4.25 – Uptake Transporters

  2010cites this paper
• Drug transporter pharmacogenetics in nucleoside-based therapies.

  2010cites this paper
• Choline and Its Products Acetylcholine and Phosphatidylcholine

  2009cites this paper
• Monoamine Transporters in Human Endometrium and Decidua

  2008cites this paper
• CHAPTER 73 – Organic Anion and Cation Transporters in Renal Elimination of Drugs

  2008cites this paper
• Organic cation transporters

  2008influential citation
• Monoamine transporters in human endometrium and decidua.

  2008cites this paper
• Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications

  2007cites this paper
• Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells.

  2007cites this paper
• 3.2 Choline and Its Products Acetylcholine and Phosphatidylcholine Choline

  2007cites this paper
• Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition f norepinephrine uptake in pregnant sheep

  2007cites this paper
• The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua

  2007influential citation
• Characterization of regulatory mechanisms and states of human organic cation transporter 2.

  2006cites this paper
• Soybean oil fat emulsion to prevent TPN-induced liver damage: possible molecular mechanisms and clinical implications.

  2006cites this paper
• Choline Transport for Phospholipid Synthesis

  2006cites this paper
• Histamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2.

  2006influential citation
• Choline Transport for Phospholipid Synthesis

  2006cites this paper
• The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α

  2006cites this paper
• Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats.

  2005cites this paper
• Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.

  2004cites this paper
• The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect.

  2004cites this paper
• Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2).

  2004cites this paper
• Molecular and cellular physiology of renal organic cation and anion transport.

  2004cites this paper
• Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25–q27

  2003cites this paper
• Organic cation transporters.

  2003cites this paper
• Structure-function relationship in P-type ATPases--a biophysical approach.

  2003cites this paper
• The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines.

  2001cites this paper
• Gene structures of the human non-neuronal monoamine transporters EMT and OCT2

  2000cites this paper
• Cellular and molecular aspects of drug transport in the kidney.

  2000cites this paper
• Molecular Pharmacology of Organic Cation Transporters in Kidney

  1999cites this paper
• Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus

  1999cites this paper
• Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.

  1999cites this paper
• Regulation of organic anion and drug transporters of the sinusoidal membrane.

  1999cites this paper
• Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)

  1999cites this paper
• Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.

  1998cites this paper
• Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.

  1998cites this paper
• Genetic Preservation of SLC22A3 in Local South African Populations

  year unknowncites this paper