Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G&agr;i1,2,3

No abstract is available for this paper.

• Publication year

  2017

• Venue

  American Journal of Respiratory Cell and Molecular Biology

• Publication date

  2017-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1165/rcmb.2016-0373OCPMID 28145731PMCID PMC5516295
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action

  2016cited by this paper
• β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function*

  2016influential reference
• A Pluridimensional View of Biased Agonism

  2016cited by this paper
• Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.

  2016cited by this paper
• Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells

  2015cited by this paper
• Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma.

  2014cited by this paper
• Points of Significance: Nested designs

  2014cited by this paper
• Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators

  2013cited by this paper
• The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.

  2012cited by this paper
• Extraoral bitter taste receptors as mediators of off‐target drug effects

  2012cited by this paper
• Bronchodilator activity of bitter tastants in human tissue

  2011cited by this paper
• Faculty Opinions recommendation of Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.

  2011influential reference
• Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors.

  2011cited by this paper
• Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events.

  2010cited by this paper
• The molecular receptive ranges of human TAS2R bitter taste receptors.

  2010cited by this paper
• Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

  2010cited by this paper
• Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors

  2008cited by this paper
• Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.

  2007cited by this paper
• β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor*

  2006cited by this paper
• beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

  2006cited by this paper
• Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle.

  2006cited by this paper
• Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation*

  2006cited by this paper
• Elucidation of mammalian bitter taste.

  2005cited by this paper
• Role of the G-Protein Subunit α-Gustducin in Taste Cell Responses to Bitter Stimuli

  2003cited by this paper
• Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli.

  2003cited by this paper
• Partial Rescue of Taste Responses of α-Gustducin Null Mice by Transgenic Expression of α-Transducin

  2002cited by this paper
• Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin.

  2002cited by this paper
• Stiffness changes in cultured airway smooth muscle cells.

  2002cited by this paper
• Activation of Cytosolic Phosphoinositide Phospholipase C by G-protein 87 Subunits *

  2001cited by this paper
• Autocrine cytokine signaling mediates effects of rhinovirus on airway responsiveness.

  2000cited by this paper
• Heterogeneity of therapeutic responses in asthma.

  2000cited by this paper
• TNF-α upregulates Giα and Gqα protein expression and function in human airway smooth muscle cells.

  1999cited by this paper
• Beta-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality?

  1999cited by this paper
• TNF-a upregulates Gia and Gqa protein expression and function in human airway smooth muscle cells

  1999cited by this paper
• β agonists: What is the evidence that their use increases the risk of asthma morbidity and mortality?

  1999cited by this paper
• Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation.

  1998cited by this paper
• Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness.

  1998cited by this paper
• Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern?

  1997cited by this paper
• Airway Subsensitivity with Long-Acting β2-Agonists

  1997cited by this paper
• Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle.

  1996cited by this paper
• Transduction of bitter and sweet taste by gustducin.

  1996cited by this paper
• Transduction of bitter and sweet taste by gustducin

  1996cited by this paper
• Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling.

  1995cited by this paper
• Gi down-regulation and heterologous desensitization in adipocytes after treatment with the alpha 2-agonist UK 14304.

  1995cited by this paper
• Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.

  1995cited by this paper
• The β2-Agonist Controversy

  1994cited by this paper
• The beta 2-agonist controversy. Observations, explanations and relationship to asthma epidemiology.

  1994cited by this paper
• Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.

  1994cited by this paper
• Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.

  1993cited by this paper
• Long-Term Effects of a Long-acting ??2-Adrenoceptor Agonist, Salmeterol, on Airways Hyperresponsiveness in Patients with Mild Asthma

  1993cited by this paper
• Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors

  1993cited by this paper
• Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.

  1992cited by this paper
• Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits.

  1992cited by this paper
• Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma.

  1992cited by this paper
• Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline.

  1985cited by this paper

• T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma.

  2025cites this paper
• Bitter taste signaling pathway is required for spermatogenesis and maintenance of male fertility in mice.

  2025cites this paper
• Shared loci but distinct variants underlie genetic architecture of allergic diseases

  2025cites this paper
• T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma

  2025cites this paper
• Structural basis of β-glucopyranoside salicin recognition by a human bitter taste GPCR.

  2025cites this paper
• A deadly taste: linking bitter taste receptors and apoptosis

  2025cites this paper
• TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization

  2025cites this paper
• Molecular Glues: A New Approach to Modulating GPCR Signaling Bias

  2025cites this paper
• Bitter taste receptor activation by cholesterol and an intracellular tastant

  2024cites this paper
• Unlocking TAS2R14 activation through intricate multi-ligand binding networks

  2024cites this paper
• The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies

  2024cites this paper
• Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5

  2024cites this paper
• Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis

  2024cites this paper
• Extragustatory bitter taste receptors in head and neck health and disease

  2024cites this paper
• Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors

  2024cites this paper
• Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

  2024cites this paper
• Bitter taste TAS2R14 activation by intracellular tastants and cholesterol

  2024cites this paper
• A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14.

  2023cites this paper
• Association of Bitter Taste Receptors with Obesity and Diabetes and Their Role in Related Tissues

  2023cites this paper
• Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Through Activation of Bitter Taste Receptor T2R14

  2023cites this paper
• Cardiac human bitter taste receptors contain naturally occurring variants that alter function.

  2023cites this paper
• Interkingdom Detection of Bacterial Quorum-Sensing Molecules by Mammalian Taste Receptors

  2023cites this paper
• Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes.

  2023cites this paper
• Bitter taste signaling in cancer.

  2023cites this paper
• Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium

  2022cites this paper
• Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma.

  2022cites this paper
• HSP90 Modulates T2R Bitter Taste Receptor Nitric Oxide Production and Innate Immune Responses in Human Airway Epithelial Cells and Macrophages

  2022cites this paper
• Emodin activates BK channel in vascular smooth muscle cells and relaxes the interlobar renal artery of rat.

  2022cites this paper
• Isoform-Specific Quantification of Human Bitter Taste Receptor Transcripts Using Real-Time PCR Analysis.

  2022cites this paper
• Taste Receptors beyond Taste Buds

  2022influential citation
• Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands

  2022cites this paper
• Association between Downstream Taste Signaling Genes, Oral Microbiome, and Severe Early Childhood Caries

  2022influential citation
• HSP90 function is required for T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages

  2021cites this paper
• Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant‐induced bronchodilation

  2021cites this paper
• Bitter Taste Receptors in the Airway Cells Functions.

  2021cites this paper
• Novel pharmacological therapies for the treatment of bronchial asthma.

  2021cites this paper
• Anti-Influenza Drug Discovery and Development: Targeting the Virus and Its Host by All Possible Means.

  2021cites this paper
• The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells

  2021cites this paper
• Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment.

  2021cites this paper
• The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14

  2021influential citation
• Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

  2020cites this paper
• Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5.

  2020cites this paper
• Opsin 3-Gαs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2.

  2020cites this paper
• Therapeutic potential and challenges of bitter taste receptors on lung cells.

  2020cites this paper
• Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling.

  2020cites this paper
• A Bitter Taste in Your Heart

  2020cites this paper
• Extraoral Taste Receptors

  2020cites this paper
• Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells

  2020cites this paper
• Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

  2019cites this paper
• Nasal commensal Staphylococcus epidermidis enhances interferon-λ-dependent immunity against influenza virus

  2019cites this paper
• Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal‐regulated Kinase 1/2

  2019cites this paper
• Cholecystokinin, gastrin, cholecystokinin/gastrin receptors, and bitter taste receptor TAS2R14: trophoblast expression and signaling.

  2019cites this paper
• Bitter Taste Receptors: Taking a Bigger Bite of Airway Smooth Muscle Pathophysiology

  2019cites this paper
• Cholesterol modulates the signaling of chemosensory bitter taste receptor T2R14 in human airway cells.

  2019cites this paper
• The future of bronchodilation: looking for new classes of bronchodilators

  2019cites this paper
• Pharmacology and Therapeutics of Bronchodilators Revisited

  2019cites this paper
• Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle

  2019cites this paper
• Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling

  2019cites this paper
• Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?

  2019cites this paper
• Differential long‐term regulation of TAS2R14 by structurally distinct agonists

  2019cites this paper
• Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine

  2019cites this paper
• Bitter Taste Receptors for Asthma Therapeutics

  2019cites this paper
• Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

  2018cites this paper
• A CREB‐mediated increase in miRNA let‐7f during prolonged β‐agonist exposure: a novel mechanism of β2‐adrenergic receptor down‐regulation in airway smooth muscle

  2018cites this paper