IRE1α-XBP1 signaling pathway, a potential therapeutic target in multiple myeloma.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis

• Publication date

  2016-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.leukres.2016.07.006PMID 27518808
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

  2016cited by this paper
• Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis

  2015cited by this paper
• GRP78-directed immunotherapy in relapsed or refractory multiple myeloma - results from a phase 1 trial with the monoclonal immunoglobulin M antibody PAT-SM6

  2015cited by this paper
• Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97

  2015cited by this paper
• Phase 1/1B trial of the heat shock protein 90 inhibitor NVP‐AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma

  2015cited by this paper
• Recent advances and future directions in targeting the secretory apparatus in multiple myeloma

  2015cited by this paper
• Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.

  2015cited by this paper
• High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib

  2014cited by this paper
• Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

  2014cited by this paper
• Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

  2014cited by this paper
• The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells

  2014cited by this paper
• Bcl-xL Protein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation*

  2014cited by this paper
• Heat shock proteins in multiple myeloma

  2014cited by this paper
• Antitumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma

  2014cited by this paper
• Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells

  2014cited by this paper
• Unfolded protein response inducers tunicamycin and dithiothreitol promote myeloma cell differentiation mediated by XBP-1

  2013cited by this paper
• Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism

  2013cited by this paper
• A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma

  2013cited by this paper
• Selective, potent blockade of the IRE1 and ATF6 pathways by 4‐phenylbutyric acid analogues

  2013cited by this paper
• Multiple myeloma Leu167Ile (c.499C>A) mutation prevents XBP1 mRNA splicing

  2013cited by this paper
• Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma

  2013cited by this paper
• Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways

  2012cited by this paper
• Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation.

  2012cited by this paper
• Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

  2012cited by this paper
• Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

  2012cited by this paper
• Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma

  2012cited by this paper
• Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.

  2011cited by this paper
• Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

  2011cited by this paper
• Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: A potential therapeutic application in multiple myeloma

  2011cited by this paper
• Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

  2011cited by this paper
• Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.

  2011cited by this paper
• Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma.

  2011cited by this paper
• Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

  2011cited by this paper
• XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments.

  2010cited by this paper
• Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

  2010cited by this paper
• IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

  2010cited by this paper
• The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress.

  2010cited by this paper
• Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

  2009cited by this paper
• XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

  2009cited by this paper
• Improved survival in multiple myeloma and the impact of novel therapies.

  2008cited by this paper
• Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

  2008cited by this paper
• Heat shock proteins as novel therapeutic targets in cancer.

  2008cited by this paper
• A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer

  2008cited by this paper
• Identification of ERdj3 and OBF-1/BOB-1/OCA-B as Direct Targets of XBP-1 during Plasma Cell Differentiation1

  2007cited by this paper
• ER stress triggers apoptosis by activating BH3-only protein Bim.

  2007cited by this paper
• Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

  2007cited by this paper
• Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

  2007cited by this paper
• Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

  2006cited by this paper
• Mediators of endoplasmic reticulum stress‐induced apoptosis

  2006cited by this paper
• Cyclin-dependent kinase inhibitors.

  2003cited by this paper
• Regulatory mechanisms that determine the development and function of plasma cells.

  2003cited by this paper
• Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis.

  2003cited by this paper
• Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.

  2003cited by this paper
• Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

  2003cited by this paper
• XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

  2003cited by this paper
• The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response

  2003cited by this paper
• Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group

  2003cited by this paper
• A time-dependent phase shift in the mammalian unfolded protein response.

  2003cited by this paper
• Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

  2003cited by this paper
• For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin–proteasome connection

  2003cited by this paper
• IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

  2002cited by this paper
• A molecular compendium of genes expressed in multiple myeloma.

  2002cited by this paper
• Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.

  2002cited by this paper
• NF-kappa B as a therapeutic target in multiple myeloma.

  2002cited by this paper
• Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

  2002cited by this paper
• Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α

  2002cited by this paper
• NF-κB as a Therapeutic Target in Multiple Myeloma*

  2002cited by this paper
• Plasma cell differentiation requires the transcription factor XBP-1

  2001cited by this paper
• Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals.

  2001cited by this paper
• XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

  2001cited by this paper
• Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications

  2001cited by this paper
• Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

  2000cited by this paper
• Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells.

  2000cited by this paper
• IRE1 and efferent signaling from the endoplasmic reticulum.

  2000cited by this paper
• PERK mediates cell-cycle exit during the mammalian unfolded protein response.

  2000cited by this paper
• Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.

  2000cited by this paper

• Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple‐negative breast cancer in female mice

  2025cites this paper
• Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives

  2025cites this paper
• Mechanism regulation of endoplasmic reticulum stress in multiple myeloma cells: modulation of the UPR, UPS, autophagy, HSPs, and potential therapeutic targets

  2025cites this paper
• Baicalein-mediated regulation of Nrf2/ARE, NFĸB, and MAPK signaling in Huntington’s disease: a promising strategy against neuroinflammation and neurodegeneration

  2025cites this paper
• Integrative analysis of an endoplasmic reticulum stress‐related signature in multiple myeloma

  2023cites this paper
• Immunomodulatory Effect of Proteasome Inhibitors via the Induction of Immunogenic Cell Death in Myeloma Cells

  2023cites this paper
• Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma.

  2023cites this paper
• The Glucose-Regulated Protein78 (GRP78) in the unfolded protein response (UPR) pathway: a potential therapeutic target for breast cancer.

  2022cites this paper
• Spliced X-Box binding protein 1 predicts satisfying responsiveness and survival benefit toward bortezomib-based therapy in multiple myeloma patients

  2022cites this paper
• Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis.

  2022cites this paper
• Endoplasmic Reticulum Stress Contributes to Copper-Induced Pyroptosis via Regulating the IRE1α-XBP1 Pathway in Pig Jejunal Epithelial Cells.

  2022cites this paper
• DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome

  2021cites this paper
• Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy.

  2021cites this paper
• Photothermal Therapy via NIR II Light Irradiation Enhances DNA Damage and Endoplasmic Reticulum Stress for Efficient Chemotherapy

  2021cites this paper
• Hyperoxia induces endoplasmic reticulum stress-associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia

  2020cites this paper
• Molecular characterization and expression pattern of inositol-requiring enzyme 1 (IRE1) in blunt snout bream (Megalobrama amblycephala): its role of IRE1 involved in inflammatory response induced by lipopolysaccharide

  2020cites this paper
• Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cells

  2020cites this paper
• Actionable Strategies to Target Multiple Myeloma Plasma Cell Resistance/Resilience to Stress: Insights From “Omics” Research

  2020cites this paper
• EGFR targeting enhances the efficiency of chemotherapy through inhibiting IRE1α-XBP1s pathway in colorectal cancer cells

  2020cites this paper
• Cell cycle exit during bortezomib‐induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s‐upregulated p21Cip1 and p27Kip1

  2020cites this paper
• Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway

  2020cites this paper
• Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib

  2020cites this paper
• Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress

  2020cites this paper
• CCDC170 affects breast cancer apoptosis through IRE1 pathway

  2020cites this paper
• X‐box binding protein 1 (XBP1) function in diseases

  2020cites this paper
• Toll-Like Receptor 4 Activation Promotes Multiple Myeloma Cell Growth and Survival Via Suppression of The Endoplasmic Reticulum Stress Factor Chop

  2019cites this paper
• Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels

  2019cites this paper
• Molecular Carcinogenesis

  2019cites this paper
• Interleukin‐6 production mediated by the IRE1‐XBP1 pathway confers radioresistance in human papillomavirus‐negative oropharyngeal carcinoma

  2019cites this paper
• Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex

  2019cites this paper
• FGF1 protects against APAP-induced hepatotoxicity via suppression of oxidative and endoplasmic reticulum stress.

  2019cites this paper
• Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells

  2019cites this paper
• Cancer stem cells and epithelial–mesenchymal transition in urothelial carcinoma: Possible pathways and potential therapeutic approaches

  2018cites this paper
• Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice.

  2018cites this paper
• The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer

  2018cites this paper
• A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation

  2018cites this paper
• ACE-2/ANG1-7 ameliorates ER stress-induced apoptosis in seawater aspiration-induced acute lung injury.

  2018cites this paper
• Estrogen receptor antagonist fulvestrant inhibits proliferation and promotes apoptosis of prolactinoma cells by regulating the IRE1/XBP1 signaling pathway.

  2018cites this paper
• IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases

  2018cites this paper
• Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress

  2017cites this paper
• Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response

  2017cites this paper
• Development and evaluation of machine learning algorithms for biomedical applications

  2017cites this paper
• Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells.

  2017cites this paper
• Endoplasmic reticulum proteostasis: a key checkpoint in cancer.

  2017cites this paper