MicroRNA‐324‐5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling

No abstract is available for this paper.

• Publication year

  2018

• Venue

  International Journal of Cancer

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.31041PMID 28905994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

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• Opposite activation of the Hedgehog pathway in CD138+ plasma cells and CD138−CD19+ B cells identifies two subgroups of patients with multiple myeloma and different prognosis

  2016influential reference
• CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy.

  2016cited by this paper
• Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients

  2015cited by this paper
• miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple Myeloma

  2015cited by this paper
• MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma

  2015cited by this paper
• MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1

  2015influential reference
• Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.

  2014cited by this paper
• A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance.

  2014cited by this paper
• Roles for Hedgehog signaling in adult organ homeostasis and repair

  2014cited by this paper
• Combination of international scoring system 3, high lactate dehydrogenase, and t(4;14) and/or del(17p) identifies patients with multiple myeloma (MM) treated with front-line autologous stem-cell transplantation at high risk of early MM progression-related death.

  2014cited by this paper
• miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/β-catenin/BCL9 pathway.

  2014cited by this paper
• miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF.

  2013cited by this paper
• RARα2 expression confers myeloma stem cell features.

  2013cited by this paper
• Identification of an ABCB1 (P‐glycoprotein)‐positive carfilzomib‐resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1

  2013cited by this paper
• The interaction of bortezomib with multidrug transporters: implications for therapeutic applications in advanced multiple myeloma and other neoplasias

  2013cited by this paper
• Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma

  2012cited by this paper
• B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells

  2012cited by this paper
• Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors

  2012cited by this paper
• microRNAs in cancer management.

  2012cited by this paper
• Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors

  2012cited by this paper
• Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.

  2012cited by this paper
• Multiple myeloma.

  2011cited by this paper
• Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

  2011cited by this paper
• Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p).

  2010cited by this paper
• International Myeloma Working Group molecular classification of multiple myeloma: spotlight review

  2009cited by this paper
• Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas.

  2009cited by this paper
• Causes and consequences of microRNA dysregulation in cancer

  2009cited by this paper
• Role of active drug transporters in refractory multiple myeloma.

  2009cited by this paper
• Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13.

  2009cited by this paper
• The hedgehog pathway and pancreatic cancer.

  2009cited by this paper
• Role of Hedgehog signaling pathway in proliferation and invasiveness of hepatocellular carcinoma cells.

  2009cited by this paper
• Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines.

  2009cited by this paper
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  2008influential reference
• Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation

  2008cited by this paper
• Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma

  2008cited by this paper
• Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.

  2008cited by this paper
• A pivotal role for Mcl-1 in Bortezomib-induced apoptosis

  2008cited by this paper
• Essential role of stromally induced hedgehog signaling in B-cell malignancies

  2007influential reference
• Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport

  2007cited by this paper
• Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

  2007cited by this paper
• Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome.

  2007cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

  2000cited by this paper
• Detection of Loss of Heterozygosityat Microsatellite Loci in Esophageal Squamous-Cell Carcinoma

  1999cited by this paper
• Drug resistance in multiple myeloma.

  1999cited by this paper
• Allogeneic transfusion and infection: economic and clinical implications.

  1997cited by this paper
• Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

  1990cited by this paper
• Allele loss on short arm of chromosome 17 in breast cancers.

  1988cited by this paper
• Multiple myeloma.

  1948cited by this paper

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  2025cites this paper
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  2023cites this paper
• Hedgehog signaling in tissue homeostasis, cancers and targeted therapies

  2023cites this paper
• Decoding the role of miRNAs in multiple myeloma pathogenesis: A focus on signaling pathways.

  2023cites this paper
• Regulation of miRNA expression by α4β1 integrin‐dependent multiple myeloma cell adhesion

  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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