Neuronal control of astrocytic respiration through a variant of the Crabtree effect

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2018-01-29

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1716469115PMID 29378955PMCID PMC5816174
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1988cited by this paper
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  1961cited by this paper
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  1955cited by this paper
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  2022cites this paper
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