Role of perfusion machines in the setting of clinical liver transplantation: A qualitative systematic review

Growing enthusiasm around machine perfusion (MP) in clinical liver transplantation (LT) may be the preamble for standardized practice to expand the donors’ pool. The present systematic review investigated all the liver transplantations performed using grafts treated with MP. A systematic review of 309 papers was performed. Eventually, 27 articles were enrolled for the study. A total number of 173 cases were reported. Only 12 cohort studies were identified: the remaining ones were case reports or case series. Hypothermic machine perfusion was performed in 102 (59.0%), normothermic machine perfusion in 65 (37.6%), and controlled oxygenated rewarming in the remaining 6 (3.4%) cases. Donor characteristics, evaluation of graft quality, and endpoints were not homogeneous among the studies. Overall, post‐LT results were excellent, with 1.2 and 4.0% of patients experienced primary non‐function and ischemic‐type biliary lesions, respectively.

• Publication year

  2018

• Venue

  Clinical Transplantation

• Publication date

  2018-06-25

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1111/ctr.13310PMID 29876967
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The first case of ischemia‐free organ transplantation in humans: A proof of concept

  2018cited by this paper
• The first case of ischemia‐free organ transplantation in humans: A proof of concept

  2018cited by this paper
• Hypothermic Oxygenated Machine Perfusion for Liver Transplantation: An Initial Experience.

  2018cited by this paper
• Hypo- and normothermic perfusion of the liver: Which way to go?

  2017cited by this paper
• Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death

  2017cited by this paper
• Hypothermic Machine Perfusion of Liver Grafts Can Safely Extend Cold Ischemia for Up to 20 Hours in Cases of Necessity.

  2017cited by this paper
• The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation.

  2017cited by this paper
• Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials

  2017cited by this paper
• Salvage of an Octogenarian Liver Graft Using Normothermic Perfusion: A Case Report.

  2017cited by this paper
• Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion

  2017cited by this paper
• Anti‐inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation

  2017cited by this paper
• The 24‐hour normothermic machine perfusion of discarded human liver grafts

  2017cited by this paper
• Normothermic Perfusion in the Assessment and Preservation of Declined Livers Before Transplantation: Hyperoxia and Vasoplegia—Important Lessons From the First 12 Cases

  2017cited by this paper
• Use of Elderly Donors in Liver Transplantation: A Paired-match Analysis at a Single Center

  2017cited by this paper
• 26-hour Storage of a Declined Liver Before Successful Transplantation Using Ex Vivo Normothermic Perfusion.

  2017cited by this paper
• Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD)

  2017cited by this paper
• Normothermic Machine Perfusion Using an Air/Oxygen Mixer for Reconditioning a Liver From a Marginal Brain Death Donor.

  2017cited by this paper
• Selection of patients with hepatocellular cancer: a difficult balancing between equity, utility, and benefit.

  2017cited by this paper
• Recent advances in the field of warm ex-vivo liver perfusion

  2017cited by this paper
• Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans.

  2017cited by this paper
• Hypothermic liver perfusion

  2017cited by this paper
• Preliminary Single‐Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial

  2017cited by this paper
• Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation: First North American results

  2016cited by this paper
• Successful Outflow Reconstruction to Salvage Traumatic Hepatic Vein-Caval Avulsion of a Normothermic Machine Ex-Situ Perfused Liver Graft

  2016cited by this paper
• Preimplant Normothermic Liver Perfusion of a Suboptimal Liver Donated After Circulatory Death

  2016cited by this paper
• Transplantation of Declined Liver Allografts Following Normothermic Ex‐Situ Evaluation

  2016cited by this paper
• Oxygenated Hypothermic Machine Perfusion After Static Cold Storage Improves Hepatobiliary Function of Extended Criteria Donor Livers

  2016cited by this paper
• Anti‐inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation

  2016cited by this paper
• Impact of Cold Ischemia Time on Outcomes of Liver Transplantation: A Single Center Experience.

  2016cited by this paper
• Development of a normothermic extracorporeal liver perfusion system toward improving viability and function of human extended criteria donor livers

  2016cited by this paper
• Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First‐in‐Man) Clinical Trial

  2016cited by this paper
• Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept

  2016cited by this paper
• First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion

  2016cited by this paper
• Normothermic Machine Perfusion of Deceased Donor Liver Grafts Is Associated With Improved Postreperfusion Hemodynamics

  2016cited by this paper
• Sequential Use of Normothermic Regional Perfusion and Hypothermic Machine Perfusion in Donation After Cardiac Death Liver Transplantation With Extended Warm Ischemia Time.

  2016cited by this paper
• A comment on the methods to evalute the performances of the normothermic perfusion technique

  2016cited by this paper
• A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion with Standard Static Cold Storage of Liver Grafts Donated after Circulatory Death in Preventing Non-anastomotic Biliary Strictures after Transplantation

  2015cited by this paper
• Hypothermic Machine Preservation Facilitates Successful Transplantation of “Orphan” Extended Criteria Donor Livers

  2015cited by this paper
• First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.

  2015cited by this paper
• Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation.

  2014cited by this paper
• The Effect of Preservation Solutions for Storage of Liver Allografts on Transplant Outcomes: A Systematic Review and Meta-Analysis

  2014cited by this paper
• Section 1. Image Evaluation of Fatty Liver in Living Donor Liver Transplantation

  2014cited by this paper
• HOPE for human liver grafts obtained from donors after cardiac death.

  2014cited by this paper
• A method for establishing allocation equity among patients with and without hepatocellular carcinoma on a common liver transplant waiting list.

  2014cited by this paper
• Graft macrosteatosis and time of T‐tube removal as risk factors for biliary strictures after liver transplantation

  2013cited by this paper
• PRISMA for Abstracts: Reporting Systematic Reviews in Journal and Conference Abstracts

  2013cited by this paper
• Assist devices: Machine preservation of extended criteria donors

  2012cited by this paper
• Increase in Mortality Rate of Liver Transplant Candidates Residing in Specific Geographic Areas: Analysis of UNOS Data

  2012cited by this paper
• Preserving the morphology and evaluating the quality of liver grafts by hypothermic machine perfusion: A proof‐of‐concept study using discarded human livers

  2012cited by this paper
• Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series

  2010cited by this paper
• Machine Perfusion Versus Cold Storage for the Preservation of Kidneys Donated After Cardiac Death: A Multicenter, Randomized, Controlled Trial

  2010cited by this paper
• Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors

  2010cited by this paper
• Machine perfusion or cold storage in deceased-donor kidney transplantation.

  2009cited by this paper
• A Novel Model Measuring the Harm of Transplanting Hepatocellular Carcinoma Exceeding Milan Criteria

  2008cited by this paper
• Association of Lower Costs of Pulsatile Machine Perfusion in Renal Transplantation from Expanded Criteria Donors

  2008cited by this paper
• Liver Transplant Using Donors After Unexpected Cardiac Death: Novel Preservation Protocol and Acceptance Criteria

  2007cited by this paper
• Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index

  2006cited by this paper
• Evaluating non-randomised intervention studies.

  2003cited by this paper
• Frederick Ronald Chistopher Casson.

  1975cited by this paper
• Kidney preservation for transportation. Initial perfusion and 30 hours' ice storage.

  1970cited by this paper
• KIDNEY PRESERVATION FOR TRANSPORTATION: II. A Simple Technique for 12‐hr Storage and Air Transport1

  1969cited by this paper

• Organ Preservation: History, Advancements, and Perspectives

  2024cites this paper
• Artificial Intelligence Algorithm-Based CTA Imaging for Diagnosing Ischemic Type Biliary Lesions after Orthotopic Liver Transplantation

  2022cites this paper
• Hospital-Based Health Technology Assessment of Machine Perfusion Systems for Human Liver Transplantation

  2022cites this paper
• How useful is the machine perfusion in liver transplantation? An answer from a national survey

  2022cites this paper
• Use of machine perfusion in livers showing steatosis prior to transplantation: a systematic review

  2020cites this paper
• Transplantation during the COVID-19 pandemic: nothing noble is accomplished without danger

  2020cites this paper
• Donor age predicts calcineurin inhibitor induced neurotoxicity after liver transplantation.

  2020cites this paper