Pathways for the regulation of body iron homeostasis in response to experimental iron overload.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Hepatology

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JHEP.2005.03.030PMID 16083989
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• African iron overload.

  2020cited by this paper
• Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis

  2005cited by this paper
• Hereditary hemochromatosis--a new look at an old disease.

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia

  2004cited by this paper
• Balancing acts: molecular control of mammalian iron metabolism.

  2004cited by this paper
• Effect of hepcidin on intestinal iron absorption in mice.

  2004cited by this paper
• Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.

  2004cited by this paper
• Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability

  2004cited by this paper
• The clinical relevance of new insights in iron transport and metabolism.

  2004cited by this paper
• Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

  2004cited by this paper
• Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat.

  2004cited by this paper
• Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

  2003cited by this paper
• Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency.

  2003cited by this paper
• Cytokine-mediated regulation of iron transport in human monocytic cells.

  2003cited by this paper
• A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption

  2003cited by this paper
• Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

  2003cited by this paper
• The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression.

  2003cited by this paper
• [Hepcidin: small molecule, large future].

  2003cited by this paper
• Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments.

  2003cited by this paper
• The orchestration of body iron intake: how and where do enterocytes receive their cues?

  2003cited by this paper
• The discovery of the new haemochromatosis gene

  2003cited by this paper
• Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.

  2003cited by this paper
• Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

  2003cited by this paper
• L’hepcidine : petite molécule, grands desseins

  2003cited by this paper
• JunB inhibits proliferation and transformation in B-lymphoid cells.

  2003cited by this paper
• Ferritin, iron homeostasis, and oxidative damage.

  2002cited by this paper
• Physiology of iron transport and the hemochromatosis gene.

  2002cited by this paper
• Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

  2002cited by this paper
• Pathways of iron absorption.

  2002cited by this paper
• Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.

  2002cited by this paper
• Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element.

  2002cited by this paper
• The labile iron pool of hepatocytes in chronic and acute iron overload and chelator-induced iron deprivation.

  2002cited by this paper
• Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.

  2002cited by this paper
• Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats.

  2002cited by this paper
• Mechanisms and regulation of intestinal iron absorption.

  2002cited by this paper
• Hereditary hemochromatosis and iron overload diseases

  2002cited by this paper
• Iron and immunity: a double‐edged sword

  2002cited by this paper
• Molecular aspects of iron absorption and HFE expression.

  2001cited by this paper
• Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption.

  2001cited by this paper
• Iron‐dependent regulation of the divalent metal ion transporter

  2001influential reference
• An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

  2001cited by this paper
• Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload.

  2001cited by this paper
• Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver*

  2001cited by this paper
• A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*

  2001cited by this paper
• Secondary iron overload.

  2001cited by this paper
• A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.

  2000cited by this paper
• African Iron Overload

  2000cited by this paper
• A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism*

  2000cited by this paper
• Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

  2000cited by this paper
• Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

  1999cited by this paper
• Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption.

  1999cited by this paper
• Iron loading and disease surveillance.

  1999cited by this paper
• Pathophysiology of Iron Overload a

  1998cited by this paper
• [Secondary iron overload].

  1998cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• Waiting for frataxin

  1997cited by this paper
• Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

  1997cited by this paper
• A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

  1996cited by this paper
• Novel Properties of L-type Polypeptide Subunits in Mouse Ferritin Molecules (*)

  1996cited by this paper
• Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited.

  1996cited by this paper
• Regulators of iron balance in humans.

  1994cited by this paper
• Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.

  1993cited by this paper
• Biologically relevant metal ion‐dependent hydroxyl radical generation An update

  1992cited by this paper
• Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

  1988cited by this paper
• Review Balancing Acts: Molecular Control of Mammalian Iron Metabolism

  year unknowncited by this paper

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  2022influential citation
• Osteoblast iron genes: real time PCR and microarray hybridization approach under hyperoxia

  2021cites this paper
• Dietary Iron Overload and Hfe−/− Related Hemochromatosis Alter Hepatic Mitochondrial Function

  2021cites this paper
• Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study.

  2021cites this paper
• Survival of Brucella abortus S19 and other Brucella spp. in the presence of oxidative stress and within macrophages

  2020cites this paper
• Ferric pyrophosphate citrate: interactions with transferrin

  2018cites this paper
• Running title: Treating Anemia of Chronic Disease

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Physiological focus on the erythropoietin-hepcidin-ferroportin axis.

  2013cites this paper
• Ezetimibe Increases Hepatic Iron Levels in Mice Fed a High-Fat Diet

  2013cites this paper
• monocytes Autocrine formation of hepcidin induces iron retention in human

  2013cites this paper
• RUTIN ATTENUATES IRON OVERLOAD-INDUCED HEPATIC OXIDATIVE STRESS IN RATS

  2013cites this paper
• The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.

  2013cites this paper
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  2012cites this paper
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  2012cites this paper
• chronic disease in rats Pharmacologic inhibition of hepcidin expression reverses anemia of

  2012cites this paper
• Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.

  2012cites this paper
• Liver hepcidin mRNA expression is inappropriately low in alcoholic patients compared with healthy controls

  2012cites this paper
• Alternative Polyadenylation and Nonsense-Mediated Decay Coordinately Regulate the Human HFE mRNA Levels

  2012cites this paper
• The Anemia of Inflammation and Chronic Disease

  2012cites this paper
• Structure and function of the iron-regulatory protein, repulsive guidance molecule c / hemojuvelin

  2011cites this paper
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  2011cites this paper
• Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

  2011cites this paper
• Hepcidin expression in the liver of rats fed a magnesium-deficient diet

  2011cites this paper
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  2011cites this paper
• Myocardial Iron Loading in Patients With Thalassemia Major in Turkey and the Potential Role of Splenectomy in Myocardial Siderosis

  2011cites this paper
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  2010cites this paper
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  2010cites this paper
• Erythrocyte Transfusions and Serum Prohepcidin Levels in Premature Newborns With Anemia of Prematurity

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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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• Interferon‐γ limits the availability of iron for intramacrophage Salmonella typhimurium

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  2008influential citation
• The influence of organic and inorganic Fe supplementation on red blood picture, immune response and quantity of iron in organs of broiler chickens.

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• Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.

  2007cites this paper
• The relevance of the intestinal crypt and enterocyte in regulating iron absorption

  2007cites this paper
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  2007cites this paper
• Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.

  2007cites this paper
• Physiologic systemic iron metabolism in mice deficient for duodenal Hfe.

  2007cites this paper
• Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

  2007cites this paper
• Petri net based model of the body iron homeostasis

  2007cites this paper
• Iron Imports. VI. HFE and regulation of intestinal iron absorption.

  2006cites this paper
• Iron and exercise induced alterations in antioxidant status. Protection by dietary milk proteins

  2006cites this paper
• Biochemical Investigations of Bowel Inflammation in Gastroschisis

  2006cites this paper
• Current World Literature

  2006cites this paper
• Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis

  2006cites this paper