Adiponectin and Metabolic Syndrome in Women at Menopause

Obesity is associated with premature atherosclerosis, as well as with many metabolic alterations including insulin resistance, dyslipidemia and hypertension. Visceral fat accumulation, particularly, is closely associated with the development of metabolic syndrome. The menopause transition, as well as the early postmenopausal period, is associated with increase in total and central obesity. Among adipocytokines secreted by the adipose tissue adiponectin is the only one that has a protective role in the development of obesity-related disorders, such as type 2 diabetes and cardiovascular disease. This review aims to present a role that adiponectin may play during the progress of menopause in relation to development of menopausal metabolic syndrome.

• Publication year

  2009

• Venue

  EJIFCC

• Publication date

  2009-01-01

• Fields of study

  Medicine

• Identifiers
  PMID 27683315PMCID 4975282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic syndrome after menopause and the role of hormones.

  2008cited by this paper
• Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women

  2008cited by this paper
• Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife: longitudinal associations

  2008cited by this paper
• Influence of age and visceral fat area on plasma adiponectin concentrations in women with normal glucose tolerance.

  2008cited by this paper
• Centrally‐located body fat is related to appetitive hormones in healthy postmenopausal women

  2008cited by this paper
• Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond.

  2008influential reference
• Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women

  2008cited by this paper
• Estrogens and glucocorticoid hormones in adipose tissue metabolism.

  2007influential reference
• Relationship of Plasma Adiponectin With Sex Hormone and Insulin‐like Growth Factor Levels

  2007cited by this paper
• Type 2 diabetes and cardiovascular disease: getting to the fat of the matter.

  2007cited by this paper
• Low levels of adiponectin predict worsening of arterial morphology and function.

  2007cited by this paper
• Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones

  2007cited by this paper
• The adiponectin role in pathogenesis of metabolic syndrome and cardiovascular disease

  2007cited by this paper
• The metabolic syndrome.

  2006influential reference
• Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans.

  2006cited by this paper
• Menopause: evidence-based practice.

  2006cited by this paper
• [The role of adiponectin in pathogenesis of metabolic syndrome and cardiovascular disease].

  2006cited by this paper
• [Sex hormones and adipocytokines in postmenopausal women].

  2006cited by this paper
• The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin‐resistant state

  2006cited by this paper
• Adipose Tissue

  2006cited by this paper
• Normative data for adiponectin, resistin, interleukin 6, and leptin/receptor ratio in a healthy Spanish pediatric population: relationship with sex steroids.

  2006cited by this paper
• Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.

  2006cited by this paper
• Regulation of adenosine 5',monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state.

  2006cited by this paper
• Endocrine and signalling role of adipose tissue: new perspectives on fat.

  2005cited by this paper
• Metabolic syndrome.

  2005cited by this paper
• Differential expression of factors involved in fat metabolism with age and the menopause transition.

  2005influential reference
• Adiponectin and adiponectin receptors.

  2005influential reference
• [Adiponectin as an adipose tissue hormone and its role in the metabolic syndrome and cardiovascular disease].

  2005cited by this paper
• Serum adiponectin concentration and cardiovascular risk factors in climacteric women

  2005influential reference
• Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels

  2005cited by this paper
• Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come.

  2005cited by this paper
• Inflammation, insulin resistance, and glucose intolerance in acute myocardial infarction patients without a previous diagnosis of diabetes mellitus.

  2005cited by this paper
• The Journal of Men's Health and Gender

  2005cited by this paper
• Adiponektyna - znaczenie w patogenezie cukrzycy typu 2

  2004cited by this paper
• [Adiponectin gene polymorphism and protein dysfunction in the development of insulin resistance].

  2004cited by this paper
• Adiponectin may play a part in the pathogenesis of diabetic retinopathy.

  2004cited by this paper
• [Adiponectin--adipocytokine with a broad clinical spectrum].

  2004cited by this paper
• Adiponectin as a biomarker of the metabolic syndrome.

  2004cited by this paper
• Menopause-related definitions

  2004cited by this paper
• Adiponectin as a potential key player in metabolic syndrome: Insights into atherosclerosis, diabetes and cancer

  2004cited by this paper
• Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution.

  2004cited by this paper
• Endokrynologia okresu przekwitania i starzenia

  2003cited by this paper
• Association between adiponectin and mediators of inflammation in obese women.

  2003cited by this paper
• Importance of Adipocytokines in Obesity-Related Diseases

  2003cited by this paper
• Hormonal changes in the menopause transition.

  2002cited by this paper
• Differences in adipose tissue metabolism between postmenopausal and perimenopausal women.

  2002influential reference
• Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women.

  2002cited by this paper
• Changes in proinflammatory cytokine activity after menopause.

  2002cited by this paper
• Racial disparities in metabolism, central obesity, and sex hormone-binding globulin in postmenopausal women.

  2001cited by this paper
• Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women.

  2000cited by this paper
• Gender-specific aspects of obesity.

  1997cited by this paper
• Changes in Energy Balance and Body Composition at Menopause: A Controlled Longitudinal Study

  1995cited by this paper

• Circadian gene expression in adolescents: Associations with concurrent circadian disruption and subsequent changes in cardiometabolic risk measures.

  2026cites this paper
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  2026cites this paper
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  2025cites this paper
• Predicting postpartum female sexual interest/arousal disorder via adiponectin and biopsychosocial factors: a cohort-based decision tree study

  2025cites this paper
• The Effect of Ovariectomy and Estradiol Substitution on the Metabolic Parameters and Transcriptomic Profile of Adipose Tissue in a Prediabetic Model

  2024cites this paper
• Influence of Mediterranean Diet on Sexual Function in People with Metabolic Syndrome: A Narrative Review

  2024cites this paper
• A systematic review and meta-analysis investigating differences in chronic inflammation and adiposity before and after menopause.

  2024cites this paper
• Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause

  2023cites this paper
• Association between Menopause, Postmenopausal Hormone Therapy and Metabolic Syndrome

  2023cites this paper
• Sex-specific associations between adipokine profiles and carotid-intima media thickness in the Cameron County Hispanic Cohort (CCHC)

  2023cites this paper
• Association of adiposity evaluated by anthropometric, BIA, and DXA measures with cardiometabolic risk factors in nonobese postmenopausal women: the CoLaus/OsteoLaus cohort

  2022influential citation
• Effect of Soy Isoflavones Supplementation on Adiponectin Levels in Postmenopausal Women

  2021cites this paper
• Sarcopenia and Appendicular Muscle Mass as Predictors of Impaired Fasting Glucose/Type 2 Diabetes in Elderly Women

  2021cites this paper
• The Relationship Between Menopause and Metabolic Syndrome: Experimental and Bioinformatics Analysis

  2021cites this paper
• Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women

  2020cites this paper
• Role of Adiponectin and Brain Derived Neurotrophic Factor in Metabolic Regulation Involved in Adiposity and Body Fat Browning

  2020cites this paper
• Gender-Specific Association of Serum Adiponectin Level with 24-Hour Heart Rate but not Blood Pressure in Female Hypertensive Patients

  2019cites this paper
• Superhongmi bran extract improves lipid profile and menopause symptoms: a randomized, placebo-controlled clinical trial

  2019cites this paper
• Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated with Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase.

  2016cites this paper
• Association of obesity with serum estrogen level in postmenopausal women

  2016cites this paper
• Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated With Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase.

  2016cites this paper
• Evaluation of metabolic syndrome in patients with NASH 1

  2014cites this paper
• Evaluation of metabolic syndrome in patients with non-alcoholic steatohepatitis.

  2014cites this paper
• Decreased plasma levels of brain-derived neurotrophic factor and its relationship with obesity and birth weight in obese Japanese children.

  2014cites this paper
• Clinical Study of Adiponectin Hormone and its Relation with some Variables in Cardiovascular Patients in Nineveh Province

  2013influential citation
• Study the levels of adiponectin, FSH, LH and Sex hormones in Type 2 diabetes (NIDDM)

  2013cites this paper
• The Relationship Between Food Intake and Adolescent Metabolic Syndrome

  2011cites this paper
• Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome

  2009cites this paper
• Correlação entre obesidade, adipocinas e sistema imunológico Correlation between obesity, adipokines and the immune system

  2009cites this paper
• Metabolic syndrome and its relationship with insulin resistance , endothelial dysfunction and atherogenesis

  2007cites this paper
• A dose–response relation between aerobic exercise and visceral fat reduction: systematic review of clinical trials

  2007cites this paper