Online tool for the discrimination of equi-distributions

BackgroundFor many applications one wishes to decide whether a certain set of numbers originates from an equiprobability distribution or whether they are unequally distributed. Distributions of relative frequencies may deviate significantly from the corresponding probability distributions due to finite sample effects. Hence, it is not trivial to discriminate between an equiprobability distribution and non-equally distributed probabilities when knowing only frequencies.ResultsBased on analytical results we provide a software tool which allows to decide whether data correspond to an equiprobability distribution. The tool is available at http://bioinf.charite.de/equifreq/.ConclusionsIts application is demonstrated for the distribution of point mutations in coding genes.

• Publication year

  2003

• Venue

  BMC Bioinformatics

• Publication date

  2003-11-21

• Fields of study

  Biology, Medicine, Physics, Computer Science

• Identifiers
  DOI 10.1186/1471-2105-4-58arXiv q-bio/0401041PMID 14629779PMCID 317281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SIFT: predicting amino acid changes that affect protein function

  2003cited by this paper
• A functional analysis of disease-associated mutations in the androgen receptor gene.

  2003cited by this paper
• Correction algorithm for finite sample statistics

  2003cited by this paper
• Finite-sample frequency distributions originating from an equiprobability distribution.

  2002cited by this paper
• The HUGO Mutation Database Initiative. Human Genome Organization.

  2002cited by this paper
• Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features

  1999cited by this paper
• The Androgen Receptor Gene Mutations Database

  1998cited by this paper
• The HUGO Mutation Database Initiative

  1998cited by this paper
• The androgen receptor gene mutations database

  1996cited by this paper
• A Statistical Approach to Vehicular Traffic

  1995cited by this paper
• Guessing probability distributions from small samples

  1995cited by this paper
• Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

  1991cited by this paper
• Identification of the cystic fibrosis gene: Chromosome walking and jumping

  1989cited by this paper
• Identification of the cystic fibrosis gene: chromosome walking and jumping.

  1989cited by this paper
• Urn models and their application

  1977cited by this paper

• Prognostic role and tumor-suppressive effects of CADM family members and the potential molecular mechanisms of CADM1 in neuroblastoma

  2025cites this paper
• Correction algorithm for finite sample statistics

  2003cites this paper