1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Neurotoxicity research

• Publication date

  2017-07-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12640-017-9782-1PMID 28721631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2018influential reference
• Safety and efficacy of chloral hydrate for conscious sedation of infants in the pediatric cardiovascular intensive care unit

  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
• Trichloroethylene and Parkinson disease.

  2011influential reference
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  2011cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1995cited by this paper
• Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.

  1995cited by this paper
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  1995cited by this paper
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  1990cited by this paper
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  1973cited by this paper
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  1970cited by this paper

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