Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

No abstract is available for this paper.

• Publication year

  2017

• Venue

  bioRxiv

• Publication date

  2017-10-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/208991PMID 29341790PMCID PMC5966786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of platelet‐derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy

  2017influential reference
• Platelet-Rich Plasma Activates Proinflammatory Signaling Pathways and Induces Oxidative Stress in Tendon Fibroblasts

  2016influential reference
• Functional Regulation of Adipose‐Derived Stem Cells by PDGF‐D

  2015cited by this paper
• TGF-&bgr; Superfamily Signaling in Muscle and Tendon Adaptation to Resistance Exercise

  2015cited by this paper
• The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

  2015cited by this paper
• Yes‐Associated Protein is up‐regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy

  2015cited by this paper
• Mechanisms of tendon injury and repair

  2015cited by this paper
• Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.

  2015cited by this paper
• Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.

  2015cited by this paper
• Harnessing endogenous stem/progenitor cells for tendon regeneration.

  2015cited by this paper
• The S6K protein family in health and disease.

  2015cited by this paper
• rhPDGF-BB Promotes Early Healing in a Rat Rotator Cuff Repair Model

  2015cited by this paper
• Molecular regulation of tendon cell fate during development

  2015cited by this paper
• Identification of an oncogenic RAB protein

  2015cited by this paper
• Pericytes: Properties, Functions and Applications in Tissue Engineering

  2015cited by this paper
• Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma

  2015cited by this paper
• Matrix metalloproteinase 14 is required for fibrous tissue expansion

  2015cited by this paper
• p38 MAPK Signaling in Postnatal Tendon Growth and Remodeling

  2015influential reference
• Small-Molecule Inhibitors of the Receptor Tyrosine Kinases: Promising Tools for Targeted Cancer Therapies

  2014cited by this paper
• A Differential Role for CD248 (Endosialin) in PDGF-Mediated Skeletal Muscle Angiogenesis

  2014cited by this paper
• Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

  2014cited by this paper
• Capillary growth in human skeletal muscle: physiological factors and the balance between pro-angiogenic and angiostatic factors.

  2014cited by this paper
• Changes in macrophage phenotype and induction of epithelial‐to‐mesenchymal transition genes following acute Achilles tenotomy and repair

  2014cited by this paper
• CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration

  2014cited by this paper
• Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix.

  2014influential reference
• Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.

  2013influential reference
• In Vivo Identity of Tendon Stem Cells and the Roles of Stem Cells in Tendon Healing

  2013cited by this paper
• Protein tyrosine phosphatases as novel targets in breast cancer therapy.

  2013cited by this paper
• Atrogin-1, MuRF-1, and sarcopenia

  2013cited by this paper
• PDGF-BB-induced MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling.

  2013influential reference
• MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix.

  2013cited by this paper
• Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts

  2013cited by this paper
• Cardiovascular , Pulmonary , and Renal Pathology MT 1-MMP – Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function Following Myocardial Infarction

  2012cited by this paper
• Effect of recombinant human platelet-derived growth factor-BB-coated sutures on Achilles tendon healing in a rat model: A histological and biomechanical study

  2012cited by this paper
• Fetal insulin and IGF-II contribute to gestational diabetes mellitus (GDM)-associated up-regulation of membrane-type matrix metalloproteinase 1 (MT1-MMP) in the human feto-placental endothelium.

  2012cited by this paper
• Physiological loading of tendons induces scleraxis expression in epitenon fibroblasts

  2012cited by this paper
• Effective fiber hypertrophy in satellite cell-depleted skeletal muscle

  2011cited by this paper
• Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers.

  2011cited by this paper
• Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

  2010cited by this paper
• Assessing the Performance Capabilities of LRE-Based Assays for Absolute Quantitative Real-Time PCR

  2010cited by this paper
• Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy

  2010cited by this paper
• Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates

  2010cited by this paper
• Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

  2010cited by this paper
• Secreted Versus Membrane-anchored Collagenases

  2009cited by this paper
• Enhanced flexor tendon healing through controlled delivery of PDGF‐BB

  2009cited by this paper
• Role of platelet-derived growth factors in physiology and medicine.

  2008cited by this paper
• Tendons of myostatin-deficient mice are small, brittle, and hypocellular

  2008cited by this paper
• Habitual loading results in tendon hypertrophy and increased stiffness of the human patellar tendon.

  2008cited by this paper
• Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons

  2007cited by this paper
• MT1‐MMP: A potent modifier of pericellular microenvironment

  2006cited by this paper
• Mechanobiology of tendon.

  2006cited by this paper
• Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.

  2006cited by this paper
• Extracellular matrix adaptation of tendon and skeletal muscle to exercise

  2006cited by this paper
• Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451.

  2005influential reference
• On the utility of pooling biological samples in microarray experiments.

  2005cited by this paper
• Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading.

  2004cited by this paper
• The Roles of Growth Factors in Tendon and Ligament Healing

  2003cited by this paper
• Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms

  2003cited by this paper
• Characterization of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in prostate cancer cell lines

  2003cited by this paper
• The proprotein convertase PACE4 is upregulated by PDGF-BB in megakaryocytes: gene expression of PACE4 and furin is regulated differently in Dami cells.

  2002cited by this paper
• Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis.

  2001cited by this paper
• Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

  2000cited by this paper
• Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor(*)

  1995cited by this paper
• Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

  1993influential reference
• Identification and characterization of PDGFR a þ mesenchymal progenitors in human skeletal muscle

  year unknowncited by this paper

• Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering

  2025cites this paper
• Diverse Roles of Tubulin Polymerization Promoting Protein 3 (TPPP3) in Human Health and Disease

  2025cites this paper
• Single-cell transcriptomics analysis of the healing process of ligament rupture

  2025cites this paper
• Programmed Drug Delivering Janus Hydrogel Adapted to the Spatio-temporal Therapeutic Window for Achilles Tendon Repair.

  2025cites this paper
• Association between Platelet-Derived Growth Factor Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma’s Efficiency in Treating Lateral Elbow Tendinopathy—A Prospective Cohort Study

  2024influential citation
• Understanding Tendon Fibroblast Biology and Heterogeneity

  2024cites this paper
• Pdgfrβ+ lineage cells transiently increase at the site of Achilles tendon healing

  2023cites this paper
• Comparison of healing of acute total tympanic membrane perforation between rats with and without excision of the mallear handle

  2023cites this paper
• Electrospun Nanofibrous Composite Membranes for Long‐Term Release of Celecoxib for Achilles Tendon Reconstruction Following Injury

  2023cites this paper
• Biological and Mechanical Factors and Epigenetic Regulation Involved in Tendon Healing

  2023cites this paper
• Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx−/− mice

  2022cites this paper
• Physical and Soluble Cues Enhance Tendon Progenitor Cell Invasion into Injectable Synthetic Hydrogels

  2022cites this paper
• The loop of phenotype: Dynamic reciprocity links tenocyte morphology to tendon tissue homeostasis.

  2022cites this paper
• PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1

  2021cites this paper
• Basic Research on Tendon Repair: Strategies, Evaluation, and Development

  2021cites this paper
• Effect of Acellular Amnion With Increased TGF-β and bFGF Levels on the Biological Behavior of Tenocytes

  2020cites this paper
• Scleraxis is required for the growth of adult tendons in response to mechanical loading

  2020influential citation
• Single-cell Transcriptomic Analyses Identifies Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons.

  2020cites this paper
• Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling.

  2020cites this paper
• A single-cell transcriptional atlas identifies extensive heterogeneity in the cellular composition of tendons

  2019cites this paper
• Flexor Tendon: Development, Healing, Adhesion Formation, and Contributing Growth Factors.

  2019cites this paper
• Insulin‐like growth factor 1 signaling in tenocytes is required for adult tendon growth

  2019influential citation
• Insulin-like growth factor 1 receptor signaling in tenocytes is required for adult tendon growth

  2019influential citation
• Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D

  2019cites this paper
• Flexor Tendon

  2019cites this paper
• Widespread diversity in the transcriptomes of functionally divergent limb tendons

  2019cites this paper
• Adaptive and Innate Immune Cell Responses in Tendons and Lymph Nodes After Tendon Injury and Repair

  2019cites this paper
• The impact of loading, unloading, ageing and injury on the human tendon

  2018influential citation