MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy

Diabetic retinopathy (DR) is a serious microvascular complication of diabetes and a major cause of blindness in the developing world. Early diabetic retinopathy is characterized by a loss of pericytes and vascular endothelial cells, a breakdown of the blood–retinal barrier, vascular dysfunction and vascular-neuroinflammation. However, optimal treatment options and related mechanisms are still unclear. MicroRNA-126 (miR-126) plays a potential role in the pathogenesis in DR, which may regulate VEGF, Ang-1 and VCAM-1 expressions. This study investigated the therapeutic effects and mechanisms of Niaspan treatment of DR in diabetes (DM) rats. DM rats exhibits significantly decreased miR-126 and tight junction Claudin-5/Occludin/ZO-1 genes expression and increased Blood retinal-barrier (BRB) breakdown, retinal apoptosis and VEGF/VEGFR, as well as VCAM-1/CD45 expressions in the retina compared to normal control group. Niaspan treatment significantly improved clinical and histopathological outcomes; decreased the expressions of VEGF/VEGFR, VCAM-1/CD45, apoptosis and BRB breakdown, significantly increased tight junction proteins and Ang-1/Tie-2 expressions, as well as increased retinal miR-126 expression compared to non-treatment diabetic rats. These data are the first to show that Niaspan treatment ameliorates DR through its repair vascular and inhibits inflammatory effects and also suggest that the miR-126 pathway may contribute to Niaspan treatment induced benefit effects.

• Publication year

  2016

• Venue

  Scientific Reports

• Publication date

  2016-05-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/srep26909PMID 27225425PMCID 4880890
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cross Talk between Lipid Metabolism and Inflammatory Markers in Patients with Diabetic Retinopathy

  2015cited by this paper
• Serum Lipids and Proliferative Diabetic Retinopathy and Macular Edema in Persons With Long-term Type 1 Diabetes Mellitus: The Wisconsin Epidemiologic Study of Diabetic Retinopathy.

  2015cited by this paper
• The Role of microRNA-126 in Vascular Homeostasis.

  2015cited by this paper
• Protective effects of methane-rich saline on diabetic retinopathy via anti-inflammation in a streptozotocin-induced diabetic rat model.

  2015cited by this paper
• Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study.

  2014cited by this paper
• Angiogenic Factors and Cytokines in Diabetic Retinopathy.

  2013cited by this paper
• Hyperglycemia-Induced Protein Kinase C β2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling

  2013cited by this paper
• Modified Lipoproteins in Diabetic Retinopathy: A Local Action in the Retina

  2013cited by this paper
• Hypoxia-Induced Deregulation of miR-126 and Its Regulative Effect on VEGF and MMP-9 Expression

  2013cited by this paper
• HDL-C: clinical equipoise and vascular endothelial function

  2013cited by this paper
• Diabetic retinopathy: current and new treatment options.

  2012cited by this paper
• Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1.

  2012cited by this paper
• Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease

  2012cited by this paper
• The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

  2012cited by this paper
• Diabetic papillopathy: current and new treatment options.

  2011cited by this paper
• Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats.

  2011cited by this paper
• Inflammation and diabetic retinal microvascular complications

  2011cited by this paper
• Global estimates of visual impairment: 2010

  2011cited by this paper
• MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats.

  2011cited by this paper
• Molecular cues guiding inflammatory responses.

  2010cited by this paper
• The opening act: vasculogenesis and the origins of circulation.

  2009cited by this paper
• Diabetic macular edema: pathogenesis and treatment.

  2009cited by this paper
• TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations

  2009cited by this paper
• MicroRNAs: Opening a New Vein in Angiogenesis Research

  2009cited by this paper
• Regulation of Endothelial Junctional Permeability

  2008cited by this paper
• miR-126 regulates angiogenic signaling and vascular integrity.

  2008cited by this paper
• Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited

  2008cited by this paper
• The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy.

  2008cited by this paper
• MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

  2008cited by this paper
• The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis.

  2008cited by this paper
• Niaspan increases angiogenesis and improves functional recovery after stroke

  2007cited by this paper
• Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

  2007cited by this paper
• Vascular permeability in ocular disease and the role of tight junctions

  2007cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid – a position paper developed by the European Consensus Panel on HDL-C*

  2004cited by this paper
• Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood–retinal barrier

  2004cited by this paper
• Suppression of diabetic retinopathy with angiopoietin-1.

  2002cited by this paper
• Leukocyte-mediated endothelial cell injury and death in the diabetic retina.

  2001cited by this paper
• [Diabetic retinopathy].

  2001cited by this paper
• Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.

  2000cited by this paper
• Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors.

  1999cited by this paper
• Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.

  1998cited by this paper
• Diabetic retinopathy.

  1998cited by this paper
• Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.

  1996cited by this paper
• Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate.

  1996cited by this paper
• Expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on proliferating vascular endothelial cells in diabetic epiretinal membranes.

  1994cited by this paper
• Low density lipoprotein cholesterol: An association with the severity of diabetic retinopathy

  1982cited by this paper

• Pericytes as Key Players in Retinal Diseases: A Comprehensive Narrative Review

  2025cites this paper
• Exploring the role of miR-126 in diabetes and its complications: a comprehensive review

  2025cites this paper
• Association between dietary niacin intake and diabetic retinopathy in a Catalonian population: a cross-sectional study

  2025cites this paper
• MicroRNAs for Diabetes Management: From Natural Bioactive Compounds to Nucleotide Networks

  2025cites this paper
• Role of MicroRNA in linking diabetic retinal neurodegeneration and vascular degeneration

  2024cites this paper
• Large-Scale Isolation of Milk Exosomes for Skincare

  2024cites this paper
• Long Non-Coding RNAs and Proliferative Retinal Diseases

  2023cites this paper
• Exosomes as biomarkers and therapy in type 2 diabetes mellitus and associated complications

  2023cites this paper
• Serum microRNA-126 expression as a biomarker of diabetic retinopathy

  2023cites this paper
• Relationship of miRNA‑126 and miRNA‑122 expression with type 2 diabetes mellitus and related glucose metabolism parameters: A systematic review and meta‑analysis.

  2022cites this paper
• Noncoding RNAs Are Promising Therapeutic Targets for Diabetic Retinopathy: An Updated Review (2017–2022)

  2022cites this paper
• The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic Retinopathy

  2022cites this paper
• Mechanistic insights into glucose induced vascular epigenetic reprogramming in type 2 diabetes.

  2022cites this paper
• OPTH_A_307009 1621..1628

  2021cites this paper
• MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF

  2021cites this paper
• MicroRNA: A mediator of diet-induced cardiovascular protection.

  2021cites this paper
• Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence

  2021cites this paper
• Focus on Diabetic Retinopathy (DR) and MicroRNA “What Association”

  2021cites this paper
• The role of microRNAs in the development of type 2 diabetes complications.

  2020cites this paper
• MicroRNAs in Vascular Eye Diseases

  2020cites this paper
• Elevated microRNA‐20b‐3p and reduced thioredoxin‐interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes

  2020cites this paper
• Dysfunctional Nurr1 promotes high glucose-induced Müller cell activation by up-regulating the NF-κB/NLRP3 inflammasome axis.

  2020cites this paper
• Molecular complexities underlying the vascular complications of diabetes mellitus - A comprehensive review.

  2020cites this paper
• Clinical significance of microRNA 126 in diabetic retinopathy in type 2 diabetes mellitus

  2020cites this paper
• Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-17-3p ameliorates inflammatory reaction and antioxidant injury of mice with diabetic retinopathy via targeting STAT1.

  2020cites this paper
• Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease.

  2019cites this paper
• Protective effects of pterostilbene on ulcerative colitis in rats via suppressing NF-κB pathway and activating PPAR-γ

  2019cites this paper
• Retina Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB 1

  2019cites this paper
• Update of inflammatory proliferative retinopathy: Ischemia, hypoxia and angiogenesis.

  2019cites this paper
• Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1.

  2019cites this paper
• MicroRNA and Microvascular Complications of Diabetes

  2018cites this paper
• Dissecting microRNA dysregulation in age‐related macular degeneration: new targets for eye gene therapy

  2018cites this paper
• The Relationship between Smoking, Alcohol Consumption and Development of Complication in Patients Having Type 2 Diabetes Mellitus, a Cross-Sectional Study

  2018cites this paper
• Association of alcohol intake with risk of diabetic retinopathy: a meta-analysis of observational studies

  2017cites this paper
• Circular non-coding RNAs in diabetic retinopathy

  2017cites this paper
• Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray

  2017cites this paper
• Recent perspectives on the delivery of biologics to back of the eye

  2017cites this paper
• Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes

  2017cites this paper
• miR‐15a/16 inhibits TGF‐beta3/VEGF signaling and increases retinal endothelial cell barrier proteins

  2017cites this paper
• Metformin inhibits development of diabetic retinopathy through microRNA-497a-5p.

  2017cites this paper
• MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence

  2016cites this paper