Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biochemical Pharmacology

• Publication date

  2016-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bcp.2016.09.013PMID 27659811
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).

  2016cited by this paper
• The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer

  2016cited by this paper
• Inhibitors of protein methyltransferases as chemical tools.

  2015cited by this paper
• Protein arginine methyltransferases (PRMTs): role in chromatin organization.

  2015cited by this paper
• Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.

  2015cited by this paper
• EZH2 Regulates Cofilin Activity and Colon Cancer Cell Migration by Targeting ITGA2 Gene

  2014cited by this paper
• Endothelial Transcriptome in Response to Pharmacological Methyltransferase Inhibition

  2014influential reference
• Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells

  2014cited by this paper
• Genetic and epigenetic aspects of breast cancer progression and therapy.

  2014cited by this paper
• EdU induces DNA damage response and cell death in mESC in culture

  2013cited by this paper
• EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells

  2013cited by this paper
• EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells

  2013cited by this paper
• Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells

  2013cited by this paper
• An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

  2013cited by this paper
• Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi-1 leukemia cells

  2013cited by this paper
• The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine

  2013cited by this paper
• A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor‐β and vascular endothelial growth factor signalling

  2013cited by this paper
• Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

  2013cited by this paper
• Novel symmetrical ureas as modulators of protein arginine methyl transferases.

  2013cited by this paper
• Understanding Histone Deacetylases in the Cancer Development and Treatment: An Epigenetic Perspective of Cancer Chemotherapy

  2012cited by this paper
• Trials with ‘epigenetic’ drugs: An update

  2012cited by this paper
• EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

  2012cited by this paper
• Epigenetic Regulation of Cell Adhesion and Communication by Enhancer of Zeste Homolog 2 in Human Endothelial Cells

  2012cited by this paper
• Histone Methylase MLL1 plays critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo

  2012cited by this paper
• EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS Brief Report: Combined Chemical Treatment Enables Oct4-Induced Reprogramming from Mouse Embryonic Fibroblasts

  2011cited by this paper
• Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements

  2011cited by this paper
• Chromatin modifying agents - the cutting edge of anticancer therapy.

  2011cited by this paper
• Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells.

  2011cited by this paper
• An Inhibitor of Protein Arginine Methyltransferases, 7,7′-Carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), Is a Potent Scavenger of NADPH-Oxidase–Derived Superoxide

  2010cited by this paper
• Asymmetric dimethylarginine in angiotensin II-induced hypertension.

  2010cited by this paper
• Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI‐1)

  2010cited by this paper
• Regulation of tumor angiogenesis by EZH2.

  2010cited by this paper
• Protein methyltransferases as a target class for drug discovery

  2009cited by this paper
• Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach.

  2009cited by this paper
• Cancer treatment of the future: inhibitors of histone methyltransferases.

  2009cited by this paper
• Targeted Metabolomic Evaluation of Arginine Methylation and Cardiovascular Risks: Potential Mechanisms Beyond Nitric Oxide Synthase Inhibition

  2009cited by this paper
• epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

  2008cited by this paper
• Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure.

  2008cited by this paper
• Role of Asymmetric Dimethylarginine in Inflammatory Reactions by Angiotensin II

  2007cited by this paper
• Angiostatic activity of DNA methyltransferase inhibitors

  2006cited by this paper
• Small Molecule Regulators of Protein Arginine Methyltransferases*

  2004influential reference
• mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.

  2003cited by this paper
• Histone lysine methylation: a signature for chromatin function.

  2003cited by this paper
• [Angiogenesis in cancer].

  2002cited by this paper
• A novel mechanism for inhibition of HIV-1 reverse transcriptase.

  2002cited by this paper
• Design

  2001cited by this paper
• Endogenous angiogenesis inhibitors and their therapeutic implications.

  2001cited by this paper
• Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study.

  2001cited by this paper
• Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.

  1999cited by this paper
• Angiogenesis in cancer, vascular, rheumatoid and other disease

  1995cited by this paper
• Micronuclei and other nuclear anomalies in buccal smears: methods development.

  1992cited by this paper
• A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

  1990cited by this paper
• Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

  1973cited by this paper
• Annals of the New York Academy of Sciences Targeting Epigenetic Regulators for Cancer Therapy

  year unknowncited by this paper

• Phytochemical Profiling, Anti-Inflammatory Action, and Human Gut Microbiota-Assisted Digestion of Rheum officinale Petiole and Root Extracts—An In Vitro Study

  2025cites this paper
• Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response

  2023cites this paper
• Downregulation of PRMT5 by AMI-1 enhances therapeutic efficacy of compound kushen injection in lung carcinoma in vitro and in vivo

  2022cites this paper
• PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions

  2022cites this paper
• The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells

  2022cites this paper
• Prognostic Role of Biomarkers for Pulmonary Arterial Hypertension Associated with Bronchopulmonary Dysplasia in Extremely Premature Infants

  2022cites this paper
• Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5

  2022cites this paper
• Retraction Retracted: Prognostic Role of Biomarkers for Pulmonary Arterial Hypertension Associated with Bronchopulmonary Dysplasia in Extremely Premature Infants

  2022cites this paper
• The Role of Lysine-Specific Demethylase 1 (LSD1) in Shaping the Endothelial Inflammatory Response.

  2021cites this paper
• Kinetics of DNA Repair in Vicia faba Meristem Regeneration Following Replication Stress

  2021cites this paper
• Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5.

  2021cites this paper
• The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

  2020cites this paper
• The New Model of Snail Expression Regulation: The Role of MRTFs in Fast and Slow Endothelial–Mesenchymal Transition

  2020cites this paper
• Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells

  2020cites this paper
• Tumor Endothelial Cell | Encyclopedia

  2020cites this paper
• The Utility of Comprehensive Metabolic Panel Tests for the Prediction of Bronchopulmonary Dysplasia in Extremely Premature Infants

  2019cites this paper
• Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

  2019cites this paper
• Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

  2019cites this paper
• Cell-specific histone modifications in atherosclerosis

  2018cites this paper
• The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting

  2018cites this paper
• Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

  2017cites this paper