Ophiopogonin D Attenuates Doxorubicin-Induced Autophagic Cell Death by Relieving Mitochondrial Damage In Vitro and In Vivo

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2015-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1124/jpet.114.219261PMID 25378375
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

  2014cited by this paper
• Activation of the p38 MAPK/NF-κB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cells.

  2013cited by this paper
• Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

  2013cited by this paper
• Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats.

  2013cited by this paper
• Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy

  2012cited by this paper
• Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms.

  2011cited by this paper
• Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress

  2011cited by this paper
• Autophagy Signaling Through Reactive Oxygen Species

  2011cited by this paper
• The role of autophagy emerging in postinfarction cardiac remodelling.

  2011cited by this paper
• Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms*

  2011cited by this paper
• Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells.

  2010influential reference
• Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death*

  2009cited by this paper
• The role of autophagy in the heart

  2009cited by this paper
• Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure.

  2009cited by this paper
• Cardiomyocyte death in doxorubicin-induced cardiotoxicity

  2009cited by this paper
• LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.

  2009cited by this paper
• ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

  2008cited by this paper
• Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion

  2008cited by this paper
• Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management.

  2007cited by this paper
• Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis

  2007cited by this paper
• Disruption of Nitric Oxide Synthase 3 Protects Against the Cardiac Injury, Dysfunction, and Mortality Induced by Doxorubicin

  2007cited by this paper
• Role of mtDNA lesions in anthracycline cardiotoxicity

  2007cited by this paper
• Role of anthracyclines in the era of targeted therapy

  2007cited by this paper
• The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

  2007cited by this paper
• New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.

  2006cited by this paper
• Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.

  2006cited by this paper
• Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents.

  2006cited by this paper
• Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy.

  2005cited by this paper
• Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

  2004cited by this paper
• Role of component herbs in antioxidant activity of shengmai san--a traditional Chinese medicine formula preventing cerebral oxidative damage in rat.

  2003cited by this paper
• Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.

  1997cited by this paper
• Lactose intolerance.

  1995cited by this paper
• Doxorubicin-induced cardiotoxicity.

  1995cited by this paper
• [Anti-arrhythmic effects and electrophysiological properties of Ophiopogon total saponins].

  1990cited by this paper
• Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

  1986cited by this paper

• Investigation of Sheng Mai Yin in the treatment of anthracycline-induced frequent premature ventricular contractions in cancer patients: study protocol for a multicenter, randomized, double-blind, placebo-controlled clinical trial

  2025cites this paper
• Stigmasterol protects H9c2 cells from angiotensin-II induced hypertrophy by regulating apoptosis and autophagy

  2025cites this paper
• Targeting autophagy in doxorubicin-induced cardiotoxicity: a comprehensive review of scientific landscapes and therapeutic innovations.

  2025cites this paper
• Modern research progress on extraction and purification, pharmacological activity, toxicology, pharmacokinetics and carrier new dosage forms of ophiopogonin

  2024cites this paper
• Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

  2024cites this paper
• Antitumor effects of ophiopogonin D on oral squamous cell carcinoma

  2024cites this paper
• Effects of Shenmai injection against chronic heart failure: a meta-analysis and systematic review of preclinical and clinical studies

  2024cites this paper
• The recent advance and prospect of natural source compounds for the treatment of heart failure

  2024cites this paper
• Ophiopogonin D: review of pharmacological activity

  2024cites this paper
• Combination therapy of acupuncture and herbal medicine for heart failure: A systematic review and meta-analysis

  2024cites this paper
• The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

  2023cites this paper
• Ophiopogonin D improves oxidative stress and mitochondrial dysfunction in pancreatic β cells induced by hydrogen peroxide through Keap1/Nrf2/ARE pathway in diabetes mellitus

  2023cites this paper
• Shengmai Yin formula promotes ventricular remodeling in chronic heart failure rats by inhibiting excessive autophagy via activating AKT/mTOR pathway

  2023cites this paper
• Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1

  2023cites this paper
• Dengzhan Shengmai capsule attenuates cardiac fibrosis in post-myocardial infarction rats by regulating LTBP2 and TGF-β1/Smad3 pathway.

  2023cites this paper
• Cell death regulation in myocardial toxicity induced by antineoplastic drugs

  2023cites this paper
• Saponins and their derivatives: potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance.

  2022cites this paper
• Characterization of quality differences of Ophiopogonis Radix from different origins by TLC, HPLC, UHPLC-MS and multivariate statistical analyses

  2022cites this paper
• Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells.

  2022cites this paper
• Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology

  2022cites this paper
• Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy

  2022cites this paper
• The role of autophagic cell death in cardiac disease.

  2022cites this paper
• Pretreatment with Shenmai Injection Protects against Coronary Microvascular Dysfunction

  2022cites this paper
• Icariin Protects H9c2 Rat Cardiomyoblasts from Doxorubicin-Induced Cardiotoxicity: Role of Caveolin-1 Upregulation and Enhanced Autophagic Response

  2021influential citation
• Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

  2021cites this paper
• Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

  2021cites this paper
• Modelling adverse drug reactions using induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs)

  2021cites this paper
• Mechanisms of Cardiomyocyte Death

  2021cites this paper
• Ophiopogonin D Inhibiting Epithelial NF-κB Signaling Pathway Protects Against Experimental Colitis in Mice

  2021cites this paper
• Regulated cell death pathways in doxorubicin-induced cardiotoxicity

  2021cites this paper
• Ophiopogonin D Alleviates Diabetic Myocardial Injuries by Regulating Mitochondrial Dynamics.

  2021cites this paper
• Autophagy and cardiac diseases: Therapeutic potential of natural products

  2020cites this paper
• Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells

  2020cites this paper
• The toxicity mechanism of different sized iron nanoparticles on human breast cancer (MCF7) cells.

  2020cites this paper
• Shenmai Injection Protects Against Doxorubicin-Induced Cardiotoxicity via Maintaining Mitochondrial Homeostasis

  2020cites this paper
• Digoxin Enhances the Anticancer Effect on Non-Small Cell Lung Cancer While Reducing the Cardiotoxicity of Adriamycin

  2020cites this paper
• Differences in the Hemolytic Behavior of Two Isomers in Ophiopogon japonicus In Vitro and In Vivo and Their Risk Warnings

  2020cites this paper
• Overview on the Side Effects of Doxorubicin

  2020cites this paper
• Imperatorin Ameliorates the Aging-Associated Porcine Oocyte Meiotic Spindle Defects by Reducing Oxidative Stress and Protecting Mitochondrial Function

  2020cites this paper
• Age-Related Considerations in Cardio-Oncology

  2020cites this paper
• Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity

  2020cites this paper
• Ophiopogonin D inhibits proliferation, migration, and invasion of hepatocellular carcinoma cells by regulating miR-519d-3p/EIF4E expression

  2019cites this paper
• Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells

  2019cites this paper
• Divaricoside Exerts Antitumor Effects, in Part, by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells

  2019cites this paper
• Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity

  2019cites this paper
• A new thiocyanoacetamide (2-cyano-2-p-nitrophenyl-N-benzylthioamide) reduces doxorubicin-induced in vitro toxicity in Sertoli cells by decreasing apoptosis and autophagy.

  2019cites this paper
• Chapter 13 Mitochondrial Dysfunction Associated with Doxorubicin

  2019cites this paper
• Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury.

  2019cites this paper
• Imperatorin improves in vitro porcine embryo development by reducing oxidative stress and autophagy.

  2019cites this paper
• Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells.

  2018cites this paper
• Autophagy: a new pathway for traditional Chinese medicine

  2018cites this paper
• Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway

  2018cites this paper
• Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells

  2018influential citation
• An immunopotentiator, ophiopogonin D, encapsulated in a nanoemulsion as a robust adjuvant to improve vaccine efficacy.

  2018cites this paper
• Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

  2018cites this paper
• Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats.

  2018cites this paper
• A novel compound DT‐010 protects against doxorubicin‐induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species‐mediated apoptotic and autophagic pathways

  2018cites this paper
• Ophiopogonin D improves osteointegration of titanium alloy implants under diabetic conditions by inhibition of ROS overproduction via Wnt/β-catenin signaling pathway.

  2018cites this paper
• Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis

  2018cites this paper
• Structural characteristics, bioavailability and cardioprotective potential of saponins

  2018cites this paper
• Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

  2018cites this paper
• Mitochondrial Dysfunction Associated with Doxorubicin

  2018cites this paper
• Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma

  2018cites this paper
• Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence.

  2018cites this paper
• Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

  2017influential citation
• Novelty application of multi-omics correlation in the discrimination of sulfur-fumigation and non-sulfur-fumigation Ophiopogonis Radix

  2017cites this paper
• Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice

  2017influential citation
• Molecular Mechanisms Underlying Anthracycline Cardiotoxicity: Challenges in Cardio-Oncology

  2017cites this paper
• Structure features and in vitro hypoglycemic activities of polysaccharides from different species of Maidong.

  2017cites this paper
• Efficacy and Mechanisms of Chinese Medicine on the Modulation of Myocardial Autophagy in Cardiovascular Disease.

  2017cites this paper
• Thrombopoietin protects H9C2 cells from excessive autophagy and apoptosis in doxorubicin-induced cardiotoxicity

  2017cites this paper
• Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion.

  2016cites this paper
• Ophiopogon japonicus--A phytochemical, ethnomedicinal and pharmacological review.

  2016cites this paper
• Quantitative determination of Radix ophiopogonison and its protective effect on intestinal ischemia reperfusion-induced lung injury in rats.

  2016cites this paper
• Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress

  2016cites this paper
• Determination of Saponin Content in Hang Maidong and Chuan Maidong via HPLC-ELSD Analysis

  2016cites this paper
• Simultaneous Qualitative and Quantitative Analysis of Multiple Chemical Constituents in YiQiFuMai Injection by Ultra-Fast Liquid Chromatography Coupled with Ion Trap Time-of-Flight Mass Spectrometry

  2016cites this paper
• New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

  2016cites this paper
• Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

  2015cites this paper
• Neuroprotective effects of Liriope platyphylla extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SH-SY5Y cells

  2015cites this paper
• Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats.

  2015cites this paper