The intricate interplay among the gasotransmitters NO, CO, H2S and mitochondrial complex IV

Submit Manuscript | http://medcraveonline.com Abbreviations: ATP: Adenosine Triphosphate; CcOX: Cytochrome c Oxidase; cGMP: Cyclic Guanosine-Monophosphate; ΔμH+: Mitochondrial H+ Electrochemical Potential Gradient; EDRF: Endothelium Derived Relaxing Factor; GAST: Gasotransmitters; GSH: Reduced Glutathione; HaCaT: Human Keratinocyte (Cell Line); HUVEC: Human Umbilical Vein Endothelial Cells; Km,O2: Michaelis Menten constant for O2(The Michaelis constant is an inverse measure of the substrate’s affinity for the enzyme, i.e. O2 for CcOX: a small Km indicates a higher affinity.); M1: Reaction Mechanism 1 of NO with cytochrome c oxidase fully reduced; M2: Reaction Mechanism 2 of NO with cytochrome c oxidase in turnover; mRNA: Mitochondrial Ribonucleic Acid; OXPHOS: Oxidative Phosphorylation; PKG: Protein kinase G; sGC: Soluble Guanylate Cyclase

• Publication year

  2018

• Venue

  Pharmacy & Pharmacology International Journal

• Publication date

  2018-02-21

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.15406/PPIJ.2018.06.00159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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